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CN 41-1437/TS  ISSN 2096-1553

整体材料的研制及其在蛋白质组色谱分离中的应用

吴慈 梁玉 梁振 张丽华 张玉奎

吴慈, 梁玉, 梁振, 等. 整体材料的研制及其在蛋白质组色谱分离中的应用[J]. 轻工学报, 2016, 31(4): 1-14. doi: 10.3969/j.issn.2096-1553.2016.4.001
引用本文: 吴慈, 梁玉, 梁振, 等. 整体材料的研制及其在蛋白质组色谱分离中的应用[J]. 轻工学报, 2016, 31(4): 1-14. doi: 10.3969/j.issn.2096-1553.2016.4.001
WU Ci, LIANG Yu, LIANG Zhen, et al. Preparation of monolithic materials and applications in proteomic chromatographic separation[J]. Journal of Light Industry, 2016, 31(4): 1-14. doi: 10.3969/j.issn.2096-1553.2016.4.001
Citation: WU Ci, LIANG Yu, LIANG Zhen, et al. Preparation of monolithic materials and applications in proteomic chromatographic separation[J]. Journal of Light Industry, 2016, 31(4): 1-14. doi: 10.3969/j.issn.2096-1553.2016.4.001

整体材料的研制及其在蛋白质组色谱分离中的应用

  • 基金项目: 国家自然科学基金项目(21575139,21235005,21190043)

  • 中图分类号: O657.7

Preparation of monolithic materials and applications in proteomic chromatographic separation

  • Received Date: 2016-04-13
    Available Online: 2016-07-15

    CLC number: O657.7

  • 摘要: 整体材料由于具有制备简单、传质速度快、低背压、表面易于修饰等优势,在色谱分离领域中应用非常广泛.为使业界了解国内外对整体材料研制的现状,对有机聚合物整体材料、硅胶整体材料、有机-无机杂化整体材料三种整体材料的制备方法及其在蛋白质组学中蛋白质和肽段色谱分离中的应用进行了综述,指出:与填充柱相比,整体柱的分离柱效仍有待进一步提高,可以从整体材料的性能,如比表面积、孔径分布、稳定性、亲水性等方面进行改进.利用整体材料低背压的优势,可制备超长、超细内径毛细管整体柱,有利于微量蛋白质组学样品的高效分离分析.随着对整体材料制备技术的不断深入研究,整体材料也将在食品安全、生命科学、环境问题等众多领域发挥更重要的作用.
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吴慈, 梁玉, 梁振, 等. 整体材料的研制及其在蛋白质组色谱分离中的应用[J]. 轻工学报, 2016, 31(4): 1-14. doi: 10.3969/j.issn.2096-1553.2016.4.001
引用本文: 吴慈, 梁玉, 梁振, 等. 整体材料的研制及其在蛋白质组色谱分离中的应用[J]. 轻工学报, 2016, 31(4): 1-14. doi: 10.3969/j.issn.2096-1553.2016.4.001
WU Ci, LIANG Yu, LIANG Zhen, et al. Preparation of monolithic materials and applications in proteomic chromatographic separation[J]. Journal of Light Industry, 2016, 31(4): 1-14. doi: 10.3969/j.issn.2096-1553.2016.4.001
Citation: WU Ci, LIANG Yu, LIANG Zhen, et al. Preparation of monolithic materials and applications in proteomic chromatographic separation[J]. Journal of Light Industry, 2016, 31(4): 1-14. doi: 10.3969/j.issn.2096-1553.2016.4.001

整体材料的研制及其在蛋白质组色谱分离中的应用

  • 中国科学院分离分析化学重点实验室, 国家色谱研究分析中心, 中国科学院大连化学物理研究所, 辽宁 大连 116023
基金项目:  国家自然科学基金项目(21575139,21235005,21190043)

摘要: 整体材料由于具有制备简单、传质速度快、低背压、表面易于修饰等优势,在色谱分离领域中应用非常广泛.为使业界了解国内外对整体材料研制的现状,对有机聚合物整体材料、硅胶整体材料、有机-无机杂化整体材料三种整体材料的制备方法及其在蛋白质组学中蛋白质和肽段色谱分离中的应用进行了综述,指出:与填充柱相比,整体柱的分离柱效仍有待进一步提高,可以从整体材料的性能,如比表面积、孔径分布、稳定性、亲水性等方面进行改进.利用整体材料低背压的优势,可制备超长、超细内径毛细管整体柱,有利于微量蛋白质组学样品的高效分离分析.随着对整体材料制备技术的不断深入研究,整体材料也将在食品安全、生命科学、环境问题等众多领域发挥更重要的作用.

English Abstract

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