烟用水基胶中苯系物和邻苯二甲酸酯类化合物的GC-MS/MS同时测定

王立云; 陈莉莎; 芦楠; 蒋成勇; 林琳; 严莉红

doi:10.3969/j.issn.2096-1553.2019.03.007

CN 41-1437/TS ISSN 2096-1553

王立云, 陈莉莎, 芦楠, 等. 烟用水基胶中苯系物和邻苯二甲酸酯类化合物的GC-MS/MS同时测定[J]. 轻工学报, 2019, 34(3): 60-67. doi: 10.3969/j.issn.2096-1553.2019.03.007

引用本文: 王立云, 陈莉莎, 芦楠, 等. 烟用水基胶中苯系物和邻苯二甲酸酯类化合物的GC-MS/MS同时测定[J]. 轻工学报, 2019, 34(3): 60-67. doi: 10.3969/j.issn.2096-1553.2019.03.007

WANG Liyun, CHEN Lisha, LU Nan, et al. Simultaneous determination of benzene series and phthalates in water-borne adhesives for cigarette by gas chromatography tandem mass spectrometry[J]. Journal of Light Industry, 2019, 34(3): 60-67. doi: 10.3969/j.issn.2096-1553.2019.03.007

Citation: WANG Liyun, CHEN Lisha, LU Nan, et al. Simultaneous determination of benzene series and phthalates in water-borne adhesives for cigarette by gas chromatography tandem mass spectrometry[J]. Journal of Light Industry, 2019, 34(3): 60-67. doi: 10.3969/j.issn.2096-1553.2019.03.007

烟用水基胶中苯系物和邻苯二甲酸酯类化合物的GC-MS/MS同时测定

1. 上海烟草集团有限责任公司技术中心北京工作站, 北京 101121;
2. 北京市烟草质量监督检测站, 北京 100029

作者简介: 王立云(1983-),女,黑龙江省绥化市人,上海烟草集团有限责任公司技术中心工程师,博士,主要研究方向为烟草化学.;

中图分类号: TS47;TQ433.4⁺3

Simultaneous determination of benzene series and phthalates in water-borne adhesives for cigarette by gas chromatography tandem mass spectrometry

1. Beijing Research Station of Technical Center, Shanghai Tobacco Group Co., Ltd., Beijing 101121, China;
2. Beijing Tobacco Quality Control & Supervision Station, Beijing 100029, China
Received Date: 2019-01-04

CLC number: TS47;TQ433.4⁺3

摘要: 以极性DB-WAX毛细管柱为色谱柱、正己烷为萃取溶剂、正十四烷为内标物，建立了利用气相色谱-串联质谱仪（GC-MS/MS）同时测定烟用水基胶中的苯系物和邻苯二甲酸酯类化合物含量的方法，并对该方法的性能进行了考察.结果表明：在萃取时间为20 min时，采用MRM模式和最佳碰撞能量条件，实现了苯系物和邻苯二甲酸酯类化合物13种组分的完全分离.该方法的相关系数>0.999，苯系物的检出限为0.000 8~0.001 0 μg/mL，定量限为0.002 5~0.003 0 μg/mL；邻苯二甲酸酯类化合物的检出限为0.003 0~0.008 0 μg/mL，定量限为0.010 0~0.030 0 μg/mL；两类化合物各加标浓度水平下的回收率为83.2%~99.8%，相对标准偏差小于7.00%.这说明该方法重复性好，回收率高，可满足定量分析要求，且定量限低于行业标准.
- 烟用水基胶 /
- GC-MS/MS /
- 苯系物 /
- 邻苯二甲酸酯类化合物
Abstract: Using a polar DB-WAX capillary column as the column, n-hexane as the extract, and n-tetradecane as the internal standard, the simultaneous determination of the waterborne adhesives by gas chromatography-tandem mass spectrometry (GC-MS/MS) was established. The method for the content of benzene series and phthalate compounds was investigated and the performance of the method was examined. The results showed that the complete separation of 13 components of benzene series and phthalate compounds was achieved by MRM mode and optimal collision energy conditions at the optimum extraction time of 20 min. The correlation coefficient of this method was >0.999, the detection limit of benzene series was 0.000 8~0.001 0 μg/mL, the limit of quantification was 0.002 5~0.003 0 μg/mL; the detection limit of phthalate compounds was 0.003 0~0.008 0 μg/mL, the limit of quantification was 0.010 0~0.030 0 μg/mL; the recoveries of the two classes of compounds at each spiked concentration level were between 83.2%~99.8%, and the relative standard deviation was less than 7.00%. This indicated that the method had good repeatability and high recovery rate, which could meet the requirements of quantitative analysis, and the limit of quantitation was lower than the industry standard.
- water-borne adhesive for cigarette /
- gas chro-matography tandem mass spectrometry /
- ben-zene series /
- phthalate compound
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王立云, 陈莉莎, 芦楠, 等. 烟用水基胶中苯系物和邻苯二甲酸酯类化合物的GC-MS/MS同时测定[J]. 轻工学报, 2019, 34(3): 60-67. doi: 10.3969/j.issn.2096-1553.2019.03.007

烟用水基胶中苯系物和邻苯二甲酸酯类化合物的GC-MS/MS同时测定

作者简介:王立云(1983-),女,黑龙江省绥化市人,上海烟草集团有限责任公司技术中心工程师,博士,主要研究方向为烟草化学.

1. 上海烟草集团有限责任公司技术中心北京工作站, 北京 101121;
2. 北京市烟草质量监督检测站, 北京 100029

收稿日期: 2019-01-04

关键词:

摘要: 以极性DB-WAX毛细管柱为色谱柱、正己烷为萃取溶剂、正十四烷为内标物，建立了利用气相色谱-串联质谱仪（GC-MS/MS）同时测定烟用水基胶中的苯系物和邻苯二甲酸酯类化合物含量的方法，并对该方法的性能进行了考察.结果表明：在萃取时间为20 min时，采用MRM模式和最佳碰撞能量条件，实现了苯系物和邻苯二甲酸酯类化合物13种组分的完全分离.该方法的相关系数>0.999，苯系物的检出限为0.000 8~0.001 0 μg/mL，定量限为0.002 5~0.003 0 μg/mL；邻苯二甲酸酯类化合物的检出限为0.003 0~0.008 0 μg/mL，定量限为0.010 0~0.030 0 μg/mL；两类化合物各加标浓度水平下的回收率为83.2%~99.8%，相对标准偏差小于7.00%.这说明该方法重复性好，回收率高，可满足定量分析要求，且定量限低于行业标准.

English Abstract

Simultaneous determination of benzene series and phthalates in water-borne adhesives for cigarette by gas chromatography tandem mass spectrometry

1. Beijing Research Station of Technical Center, Shanghai Tobacco Group Co., Ltd., Beijing 101121, China;
2. Beijing Tobacco Quality Control & Supervision Station, Beijing 100029, China

Received Date: 2019-01-04

Abstract: Using a polar DB-WAX capillary column as the column, n-hexane as the extract, and n-tetradecane as the internal standard, the simultaneous determination of the waterborne adhesives by gas chromatography-tandem mass spectrometry (GC-MS/MS) was established. The method for the content of benzene series and phthalate compounds was investigated and the performance of the method was examined. The results showed that the complete separation of 13 components of benzene series and phthalate compounds was achieved by MRM mode and optimal collision energy conditions at the optimum extraction time of 20 min. The correlation coefficient of this method was >0.999, the detection limit of benzene series was 0.000 8~0.001 0 μg/mL, the limit of quantification was 0.002 5~0.003 0 μg/mL; the detection limit of phthalate compounds was 0.003 0~0.008 0 μg/mL, the limit of quantification was 0.010 0~0.030 0 μg/mL; the recoveries of the two classes of compounds at each spiked concentration level were between 83.2%~99.8%, and the relative standard deviation was less than 7.00%. This indicated that the method had good repeatability and high recovery rate, which could meet the requirements of quantitative analysis, and the limit of quantitation was lower than the industry standard.

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