生物合成金/银纳米颗粒在化妆品领域的应用研究进展
Application and research progress of bio-synthetized gold/silver nanoparticles in the cosmetic field
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摘要: 基于生物合成的金/银纳米颗粒在皮肤医学和日用化工领域中展现的应用潜力,综述了生物合成金/银颗粒材料的生物合成法原理与相关工艺,其在化妆品中的功能特性,以及毒理学研究与人体应用安全性评估现状,指出:生物合成法可利用生物来源的有机质或还原性辅酶,在生物体的胞内或胞外制备绿色、无害的金/银纳米颗粒;生物合成的金/银纳米颗粒应用于化妆品领域具有抑菌防腐、抗氧化、抗炎修复、防晒修复等功能特性;生物合成法能显著降低金/银纳米颗粒对人体的急性毒性,但其毒效应谱尚不明确。未来应从完整生物合成机制、开展多维度的人体应用安全/功效性研究和建立针对性的风险预测模型三方面进行深入研究,进一步推动生物纳米颗粒在化妆品中的安全应用与定向开发。Abstract: Based on the application potentials of bio-synthetized gold/silver nanoparticles in the field of dermatology and daily chemical industry, this article reviewed the synthesis mechanism for bio-synthetized of gold/silver nanomaterials, functional characteristics of as-prepared nanomaterials for cosmetic applications, toxicological studies and their potential health risks. It indicated that biologically-derived organic matter or reducing coenzymes could be employed to prepare green gold/silver nanoparticles in or out of the cell of an organism; the bio-synthesized gold/silver nanoparticles could be efficiently used as antimicrobial, antioxidant, anti-inflammatory, sun protective in the cosmetic field; although numerous studies demonstrated that bio-synthesis strategy led to alleviated acute toxicity of gold/silver nanoparticles, their toxic effect spectrum was still unclear. More in-depth researches were further required for the full elucidation of biosynthesis mechanisms, establishment of multi-dimensional human safety/efficacy evaluation systems and targeted risk prediction models to further promote the security application and oriental development of biogenic nanoparticles in the cosmetic field.
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Key words:
- bio-synthetized /
- nano gold /
- nano silver /
- cosmetic efficacy /
- cosmetic safety
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