食源性活性肽调控巨噬细胞极化的研究进展

杨文建; 许征莉; 姚丽; 张传伟; 刘春利; 谢旻皓; 马宁; 苏安祥

doi:10.12187/2022.06.001

December 2022

Article Contents

YANG Wenjian, XU Zhengli, YAO Li, et al. Research progress in regulation of macrophage polarization by food-derived active peptides[J]. Journal of Light Industry, 2022, 37(6): 1-10. doi: 10.12187/2022.06.001

Citation: YANG Wenjian, XU Zhengli, YAO Li, et al. Research progress in regulation of macrophage polarization by food-derived active peptides[J]. Journal of Light Industry, 2022, 37(6): 1-10. doi: 10.12187/2022.06.001 shu

Research progress in regulation of macrophage polarization by food-derived active peptides

1. College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing 210023, China;
2. Jiangsu Health Vocational College, Nanjing 211800, China;
3. Anqiu Agricultural Technology Extension Center, Anqiu 262100, China

Received Date: 2022-05-09

Abstract

Based on the brief introduction of the characteristics food-derived active peptides and immunomodulation principle of macrophage, the source and preparation of food-derived active peptides, the phenomenon of macrophage polarization, and the mechanism of food-derived active peptides regulating macrophage polarization to exert immunomodulatory effects were highlighted in the review. It pointed out that food-derived active peptides mainly included animal sources, plant sources, microbial sources and other active peptides, and their preparation methods mainly included enzymatic hydrolysis, physical assisted enzymatic hydrolysis, microbial fermentation, microbial-enzyme synergy. The microbial-enzyme synergy method had the advantages of improving the degree of hydrolysis, conversion rate of protein and the quality of extracted peptide, which was a good method to prepare food-derived active peptides. Food-derived active peptides could regulate macrophage polarization to play an immunomodulatory role. The signal pathways including NF-κB, MAPK, and TLR4/MyD88, which were important for regulating the polarization of macrophages. However, due to the complex relationship between macrophages and health, in the future, metabolomics, gene knockout and other new technologies should be used to study the effect of food-derived active peptides on regulating macrophage polarization and health from the aspects of macrophage functional diversity and synergistic effect of signaling pathways. It was expected that this review was able to provide theoretical basis for the application of food-derived active peptides in functional food.
- food-derived active peptides,
- macrophage,
- polarization,
- immunomodulation
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Research progress in regulation of macrophage polarization by food-derived active peptides

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