黏附性聚多巴胺@己脒定二羟乙基磺酸盐微胶囊的制备及其性能研究

付向荣; 郭清泉; 汤仲标; 赵海山

doi:10.12187/2023.01.013

February 2023

Article Contents

FU Xiangrong, GUO Qingquan, TANG Zhongbiao and et al. Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules[J]. Journal of Light Industry, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013

Citation: FU Xiangrong, GUO Qingquan, TANG Zhongbiao and et al. Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules[J]. Journal of Light Industry, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013 shu

Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules

1. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;
2. Guangzhou Niqu Cosmetics Co., Ltd., Guangzhou 510660, China;
3. Guangdong Provincial People's Hospital, Guangzhou 510080, China

Received Date: 2022-01-24
Accepted Date: 2022-11-23

Abstract

Adhesive polydopamine nanocapsules containing hexamidine diisethionate (PDA@HD nanocapsules) were prepared using W₁/O/W₂ emulsion templating to enhance wet adhesion capacity of HD. Thereafter, the morphological structure, loading and release properties, adhesion properties and acute toxicity to zebrafish embryos of PDA were investigated. The results showed that the PDA@HD nanocapsules were spherical with a distinct core-shell structure whose average particle size was 353 nm. The loading ratio of PDA@HD nanocapsules could be effectively increased by increasing the concentration of HD in W₁ phase of W₁/O/W₂ emulsion. Specifically, by increasing the concentration of HD to 18 mg/mL,the loading ratio of PDA@HD nanocapsules increased to 17.1%. The release of HD in PDA@HD nanocapsules exhibited a clear pH dependence and PDA@HD nanocapsules showed better release properties in acidic environment. The adhesion force of PDA@HD nanocapsules was effectively increased about 3 times that of HD. The PDA@HD nanocapsules reduced the acute toxicity to zebrafish embryos. When the concentration of HD in PDA@HD nanocapsules was 0.5 mg/mL, all zebrafish embryos survived till 96 hpf.
- hexamidine diisethionate,
- polydopamine,
- nanocapsules,
- adhesion property,
- anti-dandruff active
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Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules

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