摘要:
依据目前国内外有关反式脂肪酸TFA(trans fatty acids)的流行病学研究成果和一些相关研究报告指出,TFA与人类Ⅱ型糖尿病、心血管疾病有相关性.TFA对人体的病理效应在于,它对血脂、炎症因子、内皮细胞功能、胰岛素抵抗及免疫力等有重要影响.膳食中的TFA进入机体组织器官后,将与多不饱和脂肪酸竞争结合过氧化物酶体增殖物活化受体PPARs(peroxisome proliferation activatedreceptors),下调PPARs对机体的保护作用,降低脂肪酸代谢酶、细胞葡萄糖转运体基因的表达,降低胰岛素受体的敏感性,并增强炎症因子的表达,造成血脂异常,胰岛素抵抗,血管内皮重构,功能紊乱,进而诱发Ⅱ型糖尿病、心血管疾病.
Abstract:
The relationship and relevant mechanism between trans fatty acids (TFA) and type Ⅱ diabetes mellitus and cardiovascular diseases are explored on the basis of overseas and domestic epidemiological studies and some research reports related with TFA.The pathologic effect of TFA on people is that has an important influence on blood fat,inflammatory factor,endotheliocyte function,insulin resistance and immunity.The diet TFA will combine peroxisome proliferation activated receptors (PPARs) competing with polyunsaturated fatty acid when it enters into the organism,down-regulate protective effect of PPARs on organism,reduce fatty acid metabolism enzyme gene expression and cell glucose transport body gene expression,reduce insulin receptor sensibility,at the same time it enhance the inflammatory factor expression and give rise to blood fat unusually,insulin resistance,vascular endothelium reconsitution and dysfunction,therefore cause to happen type Ⅱ diabetes mellitus,cardiovascular diseases.
点击查看大图
下载:
