Relationships and mechanisms of type Ⅱ diabetes mellitus and cardiovascular diseases associated with trans fatty acids

The relationship and relevant mechanism between trans fatty acids (TFA) and type Ⅱ diabetes mellitus and cardiovascular diseases are explored on the basis of overseas and domestic epidemiological studies and some research reports related with TFA.The pathologic effect of TFA on people is that has an important influence on blood fat,inflammatory factor,endotheliocyte function,insulin resistance and immunity.The diet TFA will combine peroxisome proliferation activated receptors (PPARs) competing with polyunsaturated fatty acid when it enters into the organism,down-regulate protective effect of PPARs on organism,reduce fatty acid metabolism enzyme gene expression and cell glucose transport body gene expression,reduce insulin receptor sensibility,at the same time it enhance the inflammatory factor expression and give rise to blood fat unusually,insulin resistance,vascular endothelium reconsitution and dysfunction,therefore cause to happen type Ⅱ diabetes mellitus,cardiovascular diseases.