儿茶素的药理作用研究综述
Review of research on pharmacological effects of catechins
-
摘要: 对儿茶素及其类似化合物所具有的抗氧化、保护心血管、抗肿瘤、抗菌、抗病毒、抗炎、免疫调节、神经保护、调节糖脂代谢等药理作用进行了综述,指出其具有重要的医疗保健应用价值,儿茶素类的手性研究及其体内与金属离子、蛋白质等物质的相互作用将是今后研究开发的重点.Abstract: The research progress on the pharmacology of catechins and its analogues was reviewed from remarkable pharmacological activities such as antioxidation,cardioprotection,anticancer effect,antibiosis,antiviral,anti inflammation,immunomodulation,neuroprotection,regulation of glucose and lipid metabolism and so on.It is indicated that catechins has the important medical care application value,future studies on catechins might focus on chiral resolutions and their interactions with metallic ions and proteins in vivo.
-
Key words:
- catechins /
- pharmacological effect /
- antioxidation /
- antitumor
-
-
[1]
尹志萍,张古英,王建军.儿茶及儿茶素的研究进展[J].河北医药,2008,30(3):360.
-
[2]
Ivanov S A,Nomura K,Malfanov I L,et al.Isolation of a novel catechin from Bergenia rhizomes that has pronounced lipase-inhibiting and antioxidative properties[J].Fitoterapia,2011,82:212.
-
[3]
Haza A I,Morales P.Effects of (+)-catechin and (-)-epicatechin on heterocyclic amines-induced oxidative DNA damage[J].J Appl Toxicol,2011,31:53.
-
[4]
赵文红,邓泽元,范亚苇,等.儿茶素体外抗氧化作用的研究[J].食品科技,2009,34(12):278.
-
[5]
刘珊丽,刘宗文,卢沛琦,等.儿茶素对大鼠脑缺血/再灌注损伤的保护作用及机制[J].中国药理学通报,2010,26(2):255.
-
[6]
Masaya H,Yoshihiro H,Naohisa I,et al.Protective effects of EGCG or GCG,a green tea catechin epimer,against postischemic myocardial dysfunction in guinea-pig hearts[J].Life Sciences,2007,80:1020.
-
[7]
Auclair S,Milenkovic D,Besson C,et al.Catechin reduces atherosclerotic lesion development in apo E-deficient mice:A transcriptomic study[J].Atherosclerosis,2009,204(2):e21.
-
[8]
Ihm S H,Lee J O,Kim S J,et al.Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression[J].Atherosclerosis,2009,206(1):47.
-
[9]
房磊,王捷熙,刘敏霞,等.负载表没食子儿茶素没食子酸酯对血小板功能与凋亡等影响[J].中国实验血液学杂志,2011,19( 3):764.
-
[10]
Kürbitz C,Heise D,Redmer T,et al.Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells[J].Cancer Sci,2011,102:728.
-
[11]
Rathore K,Choudhary S,Odoi A,et al.Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis[J].Carcinogenesis,2012,33:174.
-
[12]
Kuzuhara T,Suganuma M,Fujiki H.Green tea catechin as a chemical chaperone in cancer prevention[J].Cancer Lett,2008,261:12.
-
[13]
Iwasaki R,Ito K,Ishida T,et al.Catechin,green tea component,causes caspase-independent,necrosis-like cell death in chronic myelogenous leukemia[J].Cancer Sci,2009,100:349.
-
[14]
Rieko Y,Kaori S,Kenichi Y,et al.Identification of epi-gallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549[J].Toxicology in Vitro,2009,23:834.
-
[15]
周晓,王晔恺,周吉航,等.表没食子儿茶素没食子酸酯对Hela细胞的诱导凋亡作用及靶点蛋白质研究[J].中华中医药学刊,2012,30(1):194.
-
[16]
Singh B N,Shankar S,Srivastava R K.Green tea catechin,epigallocatechin-3-gallate (EGCG):Mechanisms,perspectives and clinical applications[J].Biochem Pharmacol,2011,82:1807.
-
[17]
Shimizu M,Shirakami Y,Moriwaki H.Targeting receptor tyrosine kinases for chemoprevention by green tea catechin EGCG[J].Int J Mol Sci,2008(9):1034.
-
[18]
Troparna S,Shuvojit M,Anindita D,et al.Multifunctional effect of epigallocatechin-3-gallate(EGCG) in downregu-lation of gelatinase-A(MMP-2) in human breast cancer cell line MCF-7[J].Life Sciences,2009,84:194.
-
[19]
曾亮,黄建安,李赤翎,等.儿茶素的抑菌效果及机理研究[J].食品工业科技,2009,30(5):89.
-
[20]
Xu X,Zhou X D,Wu C D.Tea catechin EGCG suppresses the mgl gene associated with halitosis[J].J Dent Res,2010,89:1304.
-
[21]
石丽桥,杨自文,王开梅,等.表没食子儿茶素没食子酸酯体外抗柯萨奇病毒的实验研究[J].时珍国医国药,2011,22(8):1945.
-
[22]
Nance C L,Siwak E B,Shearer W T.Precinical development of the green tea catechin epigallocatechin gallate as an HIV-1 therapy[J].J Allergy Clin Immunol,2009,123:459.
-
[23]
Tang L Q,Wei W,Wang X Y.Effects and mechanisms of catechin for adjuvant arthritis in rats[J].Adv Ther,2007,24:679.
-
[24]
赵兴梅,范春雷.儿茶素对小鼠巨噬细胞VCAM-1表达的影响[J].中国药理学通报,2011,27(3):443.
-
[25]
Liang O D,Kleibrink B E,Schuette-Nuetgen K,et al.Green tea epigallo-catechin-galleate ameliorates the development of obliterative airway disease[J].Exp Lung Res,2011,37:435.
-
[26]
吴奎,陈章,毕玉田,等.表没食子儿茶素没食子酸酯对哮喘小鼠呼吸道变应性炎症作用的研究[J].国际检验医学杂志,2011,32(15):1673.
-
[27]
张江江,贾永芳,李嘉雯,等.表没食子儿茶素-3-没食子酸酯抑制TNF-α和IL-1在小鼠皮肤烫伤修复期间的表达[J].中国生物化学与分子生物学报,2011,27(2):168.
-
[28]
Nakanishi T,Mukai K,Yumoto H,et al.Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors[J].Eur J Oral Sci,2010,118:145.
-
[29]
Unno K,Yamamoto H,Maeda K,et al.Protection of brain and pancreas from high-fat diet:Effects of catechin and caffeine[J].Physiol Behav,2009,96:262.
-
[30]
Srividhya R,Zarkovic K,Stroser M,et al.Mitochondrial alterations in aging rat brain:Effective role of (-)-epigallo catechin gallate[J].Int J Dev Neurosci,2009,27:223.
-
[31]
邓凤君,杨迎暴,徐江平,等.表没食子儿茶素没食子酸酯对脊髓损伤大鼠炎症因子释放及神经营养因子表达的影响[J].中国实验方剂学杂志,2010,16(5):195.
-
[32]
Kavon R Z,Arendash G W,Hou H Y,et al.Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice[J].Brain Res,2008,1214:177.
-
[33]
Tai K K,Truong D D.(-)-epigallacatechin-3-gallate (EGCG),a green tea polyphenol,reduces dichlorodi-phenyl-trichloroethane (DDT)-induced cell death in dopaminergic SHSY-5Y cells[J].Neurosci Lett,2010,482:183.
-
[34]
Ruan H,Yang Y,Zhu X,et al.Neuroprotective effects of (+/-)-catechin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mice[J].Neurosci Lett,2009,450:152.
-
[35]
Oliva J,Bardag-Gorce F,Tillman B,et al.Protective effect of quercetin,EGCG catechin and betaine against oxidative stress induced by ethanol in vitro[J].Exp Mol Pathol,2011,90:295.
-
[36]
Kobayashi H,Tanaka Y,Asagiri K,et al.The antioxidant effect of green tea catechin ameliorates experimental liver injury[J].Phytomedicine,2010,17:197.
-
[37]
Tipoe G L,Leung T M,Liong E C,et al.Epigallacate-chin-3-gallate (EGCG) reduces liver inflammation,oxidative stress and fibrosis in carbon tetrachloride(CCl4)-induced liver injury in mice[J].Toxicology,2010,273:45.
-
[38]
刘逸飞,胡玲娜,吴兴新,等.表没食子儿茶素没食子酸酯对肝星状细胞LX-2中STAT1信号的影响[J].中药新药与临床药理,2011,22(4):355.
-
[39]
曹艳,何小解,向伟,等.儿茶素对5/6肾切除大鼠肾脏微血管的保护作用及其机制[J].中西医结合学报,2009,7(6):557.
-
[40]
冯江超,邵志成,罗治彬,等.表没食子儿茶素没食子酸酯对肾间质纤维化大鼠的保护作用[J].中国老年学杂志,2011,31(7):1175.
-
[41]
谷芳芳,孙跃,许刚.儿茶素对营养性肥胖大鼠代谢综合征的防治作用[J].实用医药杂志,2010,27(9):830.
-
[42]
Klaus S,Pültz S,Thne-Reineke C,et al.Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation[J].Int J Obes (Lond),2005,29:615.
-
[43]
Kamiyama O,Sanae F,Ikeda K,et al.In vitro inhibition of α-glucosidases and glycogen phosphorylase by catechin gallates in green tea[J].Food Chem,2010,122:1061.
-
[44]
Furuyashiki T,Nagayasu H,Aoki Y,et al.Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells[J].Biosci Biotechnol Biochem,2004,68:2353.
-
[45]
赵先哲,乔伟伟.表没食子儿茶素没食子酸酯对大鼠胰岛素抵抗的影响[J].中国实验动物学报,2011,19(6):489.
-
[46]
Shin D W,Kim S N,Lee S M,et al.(-)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPAR gamma transactivation[J].Biochem Pharmacol,2009,77:125.
-
[47]
Rao C V,Vijayakumar M.Protective effect of (+)-catechin against gastric mucosal injury induced by ischaemia-reperfusion in rats[J].J Pharm Pharmacol,2007,59:1103.
-
[48]
闫丽莎,刘屏,王东晓,等.儿茶素对小鼠造血祖细胞的刺激增殖作用[J].中国药师,2008,11(5):492.
-
[49]
Nakamura H,Ukai T,Yoshimura A,et al.Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo[J].J Periodontal Res,2010,45:23.
-
[50]
Kalender Y,Kaya S,Durak D,et al.Protective effects of catechin and quercetin on antioxidant status,lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats[J].Environ Toxicol Pharmacol,2012,33:141.
-
[1]
计量
- PDF下载量: 55
- 文章访问数: 2154
- 引证文献数: 0