MA Lin, KOU Xiao-teng, TIE Jin-xin, et al. Study on the safety of 6-hydroxynicotine compared with nicotine[J]. Journal of Light Industry, 2013, 28(1): 25-29. doi: 10.3969/j.issn.2095-476X.2013.01.006
Citation:
MA Lin, KOU Xiao-teng, TIE Jin-xin, et al. Study on the safety of 6-hydroxynicotine compared with nicotine[J]. Journal of Light Industry, 2013, 28(1): 25-29.
doi:
10.3969/j.issn.2095-476X.2013.01.006
Study on the safety of 6-hydroxynicotine compared with nicotine
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Received Date:
2012-12-10
Available Online:
2013-01-15
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Abstract
he safety of 6-hydroxynicotine and nicotine was compared through toxicology test.The acute toxicity and accumulative test was carried out on SPF mice(each of 30~35 g).After 35 d intragastrically each of 1.00 mg,0.75 mg,0.5 mg,0.25 mg of nicotine and 6-hydroxynicotine(about receive the amount of a man pumping 20 cigarettes a day 8,6,4,2 times),the organ coefficient of heart,liver,spleen,lung and kidney were calculated and bloodindicators of ALT,AST,TG were determined,the pathological examination was also done using liver,lung and kidney tissue.The results showed that 6-hydroxynicotine compared to nicotine significantly reduced in toxicity(P < 0.05),low doses of nicotine does not cause organ lesions in mice.
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Proportional views
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