DNA逻辑自组装体构建的研究进展
Research progress in the construction of DNA logic self-assembly
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摘要: 对DNA自组装原理、DNA编码序列设计、DNA自组装基元和自组装体的构建等方面的研究现状进行了述评，提出构建复杂的DNA自组装体仍是该领域的研究难题，未来的研究将主要集中于三方面：1）基于DNA的热力学属性和物理化学属性，建立DNA自组装基元类型库和DNA自组装结构体；2）整合和挖掘高通量的DNA自组装实证数据，以数据为驱动，搭建适合描述DNA自组装体的系统模型；3）进行DNA自组装载药体系的可控性、适应性和应用性分析.Abstract: The principles of the DNA self-assembly,the design of the DNA coding sequence,DNA essential assemble units, and the construction of the DNA self-assembly system have been reviewed.The construction of the DNA self-assembly system is a difficult problem in this field.Three aspects will be focused in future research:first,based on thermodynamic and physico-chemical properties of DNA,DNA essential assemble units and DNA self-assembly system will be constructed;second,high-throughput empirical data of DNA self-assembly will be integrated and mined,the model of the DNA self-assembly system will be designed according to data-driven;at last,the controllability,adaptability and applicability of drug delivery system DNA self-assembly will be analyzed.
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Key words:
- DNA logic self-assembly /
- DNA encoding /
- DNA tile /
- fundamental assemble unit
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