荆芥复方提取液的抗敏功效研究
Study on anti-allergy efficacy of Nepeta cataria prescriptions
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摘要: 采用水提取法制备出荆芥复方提取液（生药的质量浓度0.05 g/mL），通过样品对豚鼠皮肤瘙痒模型的体内止痒实验、大鼠被动皮肤过敏模型的抗敏作用实验和豚鼠皮肤脱水模型的皮肤修复作用实验，评估荆芥复方提取液在动物水平上的抗敏功效.实验结果表明，在0.5 wt%受试浓度下，磷酸组胺致痒阈达（154±31）μg；在2.0 wt%受试浓度下，毛细血管通透性降低率为15.5%；在0.5 wt%受试浓度下，敏后肌肤水分散失保护率为18%.这说明荆芥复方提取液在动物水平上具有良好的止痒、消肿及敏后修复功效.Abstract: Nepeta cataria prescriptions were extracted with distilled water and the mass concentration of Nepeta cataria in the extract was 0.05 g/mL.The animal models of anti-pruritus,passive cutaneous anaphylaxis (PCA) and dehydrated skin of guinea pig after allergy were applied to study relieve itching,detumescence and allergic skin repair activity of the active extraction.Results showed that the extracts of Nepeta cataria prescriptions with mass concentration of 0.5 wt% could significantly mitigated the amount of the histamine phosphate and run up the threshold of itch at (154±31) μg.Further,vascular permeability by 15.5% with mass concentration of 2.0 wt% and the protection rate of water dispersion in allergic skin was 18% with mass concentration of 0.5 wt%.Meanwhile,the extract of Nepeta cataria prescriptions in cream matrix also could promote relieve itching,eliminate the redness of red and moisturize the allergic skin in clinical evaluation.
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Key words:
- Nepeta cataria /
- prescriptions /
- anti-allergy efficacy /
- mice level
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[1]
董银卯.萌芽绿豆抗敏抗氧化活性物质分析及其作用机制研究[D].哈尔滨:哈尔滨工业大学,2014.
-
[2]
薛素琴.治疗慢性湿疹新药消炎止痒凝胶的开发研究[D].广州:广州中医药大学,2009.
-
[3]
金云隆.中药抗过敏实验刍议[J].中国中医药现代远程教育,2011,9(1):220.
-
[4]
ZHANG W,MA D,ZHAO Q,et al.The effect of the major components of fructus cnidii on osteoblasts in vitro[J].Journal of Acupuncture and Meridian Studies,2010,3(1):32.
-
[5]
高天红,朴晋华,王婷婷.鱼金注射液被动皮肤过敏试验及对血清IgE的影响[J].山西医科大学学报,2011,42(6):477.
-
[6]
张信岳,陈爱君,李钦,等.绿原酸主动全身过敏与被动皮肤过敏的实验研究[J].中国中医药科技,2011,18(2):127.
-
[7]
陈小文,杨慧,刘玉琳.IL-18与过敏性疾病[J].生命的化学,2007,27(5):441.
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