JOURNAL OF LIGHT INDUSTRY

CN 41-1437/TS  ISSN 2096-1553

氨基功能化有机-无机杂化介孔材料合成及药物释放性能研究

王培远 ,  康华魁 ,  孙淑敏 ,  方少明

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王培远, 康华魁, 孙淑敏, 等. 氨基功能化有机-无机杂化介孔材料合成及药物释放性能研究[J]. 轻工学报, 2013, 28(4): 1-5. doi: 10.3969/j.issn.2095-476X.2013.04.001
引用本文: 王培远, 康华魁, 孙淑敏, 等. 氨基功能化有机-无机杂化介孔材料合成及药物释放性能研究[J]. 轻工学报, 2013, 28(4): 1-5. doi: 10.3969/j.issn.2095-476X.2013.04.001
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WANG Pei-yuan, KANG Hua-kui, SUN Shu-min and et al. Study on synthesis of amino functionalized organic-inorganic hybrid mesoporous materials and drug delivery property[J]. Journal of Light Industry, 2013, 28(4): 1-5. doi: 10.3969/j.issn.2095-476X.2013.04.001
Citation: WANG Pei-yuan, KANG Hua-kui, SUN Shu-min and et al. Study on synthesis of amino functionalized organic-inorganic hybrid mesoporous materials and drug delivery property[J]. Journal of Light Industry, 2013, 28(4): 1-5. doi: 10.3969/j.issn.2095-476X.2013.04.001
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氨基功能化有机-无机杂化介孔材料合成及药物释放性能研究

  • 郑州轻工业学院 材料与化学工程学院, 河南 郑州 450001;

  • 郑州轻工业学院 河南省表界面科学重点实验室, 河南 郑州 450001

    • 通讯作者: 方少明

  • 基金项目: 郑州轻工业学院博士基金项目(2011BSJJ011,2011BSJJ010)
    国家自然科学基金项目(21104070)

  • 中图分类号: O621.3

Study on synthesis of amino functionalized organic-inorganic hybrid mesoporous materials and drug delivery property

  • College of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China;

  • He'nan Provincial Key Labortory of Surface and Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450001, China

    • Corresponding author: FANG Shao-ming,
  • Received Date: 2013-03-08
    Available Online: 2013-07-15

    CLC number: O621.3

  • 摘要: 以1,2-二(三甲氧基硅基)乙烷(BTME)和3-氨基丙基三乙氧基硅烷(AMPTS)为前驱体,通过共缩聚的方法合成氨基修饰的乙烷桥联的有序介孔氧化硅,并对其进行表征;再以布洛芬为模型药物,将得到的材料用于药物的吸附与释放,研究其药物释放性能.结果表明,氨基修饰后的杂化介孔材料对布洛芬具有更强的吸附能力,从修饰前的0.35 g/g增加至0.78 g/g.与未修饰的材料EA-0相比,氨基功能的材料EA-20在释放过程中具有更好的缓释效果.
    Abstract: Amino group-functionalized mesoporous ethane-silicas were synthesized by co-condensation of 1,2-bis(trimethoxysily)ethane (BTME) and 3-aminopropyltriethoxysilane(AMPTS).TEM,XRD,nitrogen adsorption and desorption,FT-IR,elemental analysis and 13C NMR were used to characterize the obtained materials.Ibuprofen was used as a model drug to test the drug adsorption and release properties of mesoporous materials.The results showed that amino group-functionalized mesoporous ethane-silicas presented stronger adsorption capacity,which could increase up to 0.78 g/g from 0.35 g/g.Compared with EA-0,the materials EA-20 had a better sustained release effect during the release process.
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  • 通讯作者:  方少明,
  • 收稿日期:  2013-03-08
  • 刊出日期:  2013-07-15
通讯作者: 陈斌, bchen63@163.com
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王培远, 康华魁, 孙淑敏, 等. 氨基功能化有机-无机杂化介孔材料合成及药物释放性能研究[J]. 轻工学报, 2013, 28(4): 1-5. doi: 10.3969/j.issn.2095-476X.2013.04.001
引用本文: 王培远, 康华魁, 孙淑敏, 等. 氨基功能化有机-无机杂化介孔材料合成及药物释放性能研究[J]. 轻工学报, 2013, 28(4): 1-5. doi: 10.3969/j.issn.2095-476X.2013.04.001
shu
WANG Pei-yuan, KANG Hua-kui, SUN Shu-min and et al. Study on synthesis of amino functionalized organic-inorganic hybrid mesoporous materials and drug delivery property[J]. Journal of Light Industry, 2013, 28(4): 1-5. doi: 10.3969/j.issn.2095-476X.2013.04.001
Citation: WANG Pei-yuan, KANG Hua-kui, SUN Shu-min and et al. Study on synthesis of amino functionalized organic-inorganic hybrid mesoporous materials and drug delivery property[J]. Journal of Light Industry, 2013, 28(4): 1-5. doi: 10.3969/j.issn.2095-476X.2013.04.001
shu

氨基功能化有机-无机杂化介孔材料合成及药物释放性能研究

    通讯作者: 方少明
  • 郑州轻工业学院 材料与化学工程学院, 河南 郑州 450001;
  • 郑州轻工业学院 河南省表界面科学重点实验室, 河南 郑州 450001
  • 收稿日期: 2013-03-08
  • 网络出版日期: 2013-07-15
基金项目:  郑州轻工业学院博士基金项目(2011BSJJ011,2011BSJJ010)国家自然科学基金项目(21104070)

摘要: 以1,2-二(三甲氧基硅基)乙烷(BTME)和3-氨基丙基三乙氧基硅烷(AMPTS)为前驱体,通过共缩聚的方法合成氨基修饰的乙烷桥联的有序介孔氧化硅,并对其进行表征;再以布洛芬为模型药物,将得到的材料用于药物的吸附与释放,研究其药物释放性能.结果表明,氨基修饰后的杂化介孔材料对布洛芬具有更强的吸附能力,从修饰前的0.35 g/g增加至0.78 g/g.与未修饰的材料EA-0相比,氨基功能的材料EA-20在释放过程中具有更好的缓释效果.

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