[1] 崔立柱,付依依,刘士伟,等.沙棘营养价值及产业发展概况[J].食品研究与开发,2021,42(11):218-224.
CUI L Z,FU Y Y,LIU S W,et al.Nutritional value and industry development of sea buckthorn[J].Food Research and Development,2021,42(11):218-224.
[2] 王宁宁,郑文惠,张凯雪,等.沙棘的化学成分、药理作用研究进展及其质量标志物的预测分析[J].中国中药杂志,2021,46(21):5522-5532.
WANG N N,ZHENG W H,ZHANG K X,et al.Research progress on chemical constituents and pharmacological activities of sea buckthorn and prediction of its Q-markers[J].China Journal of Chinese Materia Medica,2021,46(21):5522-5532.
[3] 王晓琴,徐僮,刘悦,等.沙棘属药用植物亲缘学研究进展[J].世界中医药,2021,16(15):2217-2227.
WANG X Q,XU T,LIU Y,et al.Research progress on the relative theory of medicinal plants of Hippophae L[J].World Chinese Medicine,2021,16(15):2217-2227.
[4] 宇妥·云丹贡布.四部医典:藏文版[M].拉萨:西藏人民出版社,1982:65. YUTHOK Y D G B.Four medical tantras:Tibetan version[M].Lhasa:Tibet People’s Publishing House,1982:65.
[5] 国家药典委员会.中华人民共和国药典:二部[M].北京:人民卫生出版社,1977:303. National Pharmacopoeia Committee.Pharmacopoeia of the people’s republic of China:Ⅱ[M].Beijing:People’s Medical Publishing House,1977:303.
[6] ZULFIQAR R,FATIMA K,HAQ I U,et al.The miracle Berry:Unveiling the therapeutic attributes of sea buckthorn:A review [J].Human Nutrition & Metabolism,2025,41:200321.
[7] SINGH B,OBEROI S,KAUR A.Phenolic compounds in sea buckthorn (Hippophae rhamnoides L.)and their health-promoting activities:A review [J].International Journal of Food Science and Technology,2024,59(9):6642-58.
[8] 郭瑞雪.沙棘酚类物质生物活性、生物利用度及其体内外抑制乳腺癌细胞增殖的机理研究[D].广州:华南理工大学,2019. GUO R X.Bioactivities and bioavailability of Hippophaë rhamnoids L.phenolics and their anticancer mechanism towards human breast cancer cells both in vitro and in vivo[D].Guangzhou:South China University of Technology, 2019.
[9] 丁丽娜,邱亦亦,束彤,等.超高效液相色谱-质谱联用技术解析沙棘果超临界CO2萃取物中黄酮类天然产物结构[J].食品科学,2019,40(18):273-280.
DING L N,QIU Y Y,SHU T,et al.Determination of flavonoids in the supercritical CO2 extract of sea buckthorn fruit by using ultra-high performance liquid chromatography-mass spectrometry[J].Food Science,2019,40(18):273-280.
[10] 孙燕,冯峰,黄特辉,等.基于UPLC-Q-Exactive技术结合OTCML数据库快速分析沙棘的功效成分[J].天然产物研究与开发,2019,31(7):1192-1202.
SUN Y,FENG F,HUANG T H,et al.Rapid analysis of functional components of Hippophae rhamnoides by UPLC-Q-Exactive and OTCML database[J].Natural Product Research and Development,2019,31(7):1192-1202.
[11] CRISTE A,URCAN A C,BUNEA A,et al.Phytochemical composition and biological activity of berries and leaves from four Romanian Sea buckthorn (Hippophae rhamnoides L.)varieties[J].Molecules,2020,25(5):1170.
[12] OLAS B.Sea buckthorn as a source of important bioactive compounds in cardiovascular diseases[J].Food and Chemical Toxicology,2016,97:199-204.
[13] POP R M,SOCACIU C,PINTEA A,et al.UHPLC/PDA-ESI/MS analysis of the main berry and leaf flavonol glycosides from different carpathian Hippophaë rhamnoides L.varieties[J].Phytochemical Analysis,2013,24(5):484-492.
[14] 孙燕.沙棘中功效成分液相色谱-高分辨质谱精准检测鉴定技术研究[D].北京:北京中医药大学,2019. SUN Y.Study on accurate detection and identification techniques for bioactive components in Hippophae rhamnoides L.using liquid chromatography-high-resolution mass spectrometry[D].Beijing:Beijing University of Chinese Medicine,2019.
[15] JI M Y,GONG X,LI X,et al.Advanced research on the antioxidant activity and mechanism of polyphenols from Hippophae species:A review[J].Molecules,2020,25(4):917.
[16] CIESAROVÁ Z,MURKOVIC M,CEJPEK K,et al.Why is sea buckthorn (Hippophae rhamnoides L.)so exceptional?A review[J].Food Research International,2020,133:109170.
[17] TKACZ K,WOJDYŁO A,TURKIEWICZ I P,et al.UPLC-PDA-Q/TOF-MS profiling of phenolic and carotenoid compounds and their influence on anticholinergic potential for AChE and BuChE inhibition and on-line antioxidant activity of selected Hippophaë rhamnoides L.cultivars[J].Food Chemistry,2020,309:125766.
[18] FANG R,VEITCH N C,KITE G C,et al.Enhanced profiling of flavonol glycosides in the fruits of sea buckthorn (Hippophae rhamnoides)[J].Journal of Agricultural and Food Chemistry,2013,61(16):3868-3875.
[19] MA X Y,MOILANEN J,LAAKSONEN O,et al.Phenolic compounds and antioxidant activities of tea-type infusions processed from sea buckthorn (Hippophaë rhamnoides)leaves[J].Food Chemistry,2019,272:1-11.
[20] 邢津津.西藏林芝沙棘成分分析、黄酮提取优化及抗氧化性研究[D].林芝:西藏农牧学院,2021. XING J J.Analysis of components and flavonoids of Hippophae Rhamnoides Linzhi from Tibet Study on extraction optimization andantioxidant activity[D].Nyingchi:Tibet Agriculture and Animal Husbandry University,2021.
[21] 吴斯琴毕力格,包勒朝鲁,那生桑.沙棘药理作用研究进展[J].中国药业,2015,24(1):95-97.
Wusiqinbilige,Baolechaolu,Nashengsang.Research progress on pharmacological effects of Hippophae rhamnoides[J].China Pharmaceuticals,2015,24(1):95-97.
[22] 冉贝贝,李卫东.沙棘果与沙棘叶化学成分及其差异的研究进展[J].中国中药杂志,2019,44(9):1767-1773.
RAN B B,LI W D.Research progress on chemical constituents and their differences between sea buckthorn berries and leaves[J].China Journal of Chinese Materia Medica,2019,44(9):1767-1773.
[23] 亓金钗,陈静,李文,等.基于“干法+湿法”联用技术探究西藏沙棘抗氧化质量标志物[J].中国中药杂志,2021,46(11):2699-2709.
QI J C,CHEN J,LI W,et al.Explore antioxidant quality markers of Hippophae tibetana based on “dry-method +wet-method”technology[J].China Journal of Chinese Materia Medica,2021,46(11):2699-2709.
[24] 王琬宁.沙棘果实中黄酮类物质的分析[D].哈尔滨:东北农业大学,2020. WANG W N.Analysis of flavonoids in sea buckthorn fruits[D].Harbin:Northeast Agricultural University,2020.
[25] GUTZEIT D,WRAY V,WINTERHALTER P,et al.Preparative isolation and purification of flavonoids and protocatechuic acid from sea buckthorn juice concentrate (Hippophaё rhamnoides L.ssp rhamnoides)by high-speed counter-current chromatography[J].Chromatographia,2007,65(1/2):1-7.
[26] 郭建峰,郄浩然,王芳,等.沙棘叶黄酮的提取纯化及组成分析[J].现代食品科技,2022,38(5):189-198.
GUO J F,QIE H R,WANG F,et al.Extraction,purification and composition analysis of flavonoids from sea buckthorn leaves[J].Modern Food Science and Technology,2022,38(5):189-198.
[27] 丁金.沙棘活性成分分离制备及抗多柔比星致心肌细胞损伤的研究[D].烟台:烟台大学,2020. DING J.Preparation of active components from Hippophae rhamnoides Linn.and study on doxorubicin-induced H9c2 myocardial injury[D].Yantai:Yantai University,2020.
[28] 郑文惠.沙棘不同部位的代谢组学分析及抗炎活性研究[D].兰州:兰州大学,2020. ZHENG W H.Metabolomics research and anti-inflammatory study of different parts of Hippophae rhamnoides L.[D].Lanzhou:Lanzhou University,2020.
[29] GOOSSENS J F,GOOSSENS L,BAILLY C.Hinokiflavone and related C—O—C-type biflavonoids as anti-cancer compounds:properties and mechanism of action [J].Natural Products and Bioprospecting,2021,11(4):365-77.
[30] JASTRZAB A,SKRZYDLEWSKA E.Composition and biomedical relevance of sea buckthorn[J].Acta Poloniae Pharmaceutica-Drug Research,2019,76(6):959-969.
[31] GHENDOV-MOSANU A,CRISTEA E,PATRAS A,et al.Potential application of Hippophae rhamnoides in wheat bread production[J].Molecules,2020,25(6):1272.
[32] DANIELSKI R,SHAHIDI F.Phenolic composition and bioactivities of sea buckthorn (Hippophae rhamnoides L.)fruit and seeds:An unconventional source of natural antioxidants in North America[J].Journal of the Science of Food and Agriculture,2024,104(9):5553-5564.
[33] BITTOVÁ M,KREJZOVÁ E,ROBLOVÁ V,et al.Monitoring of HPLC profiles of selected polyphenolic compounds in sea buckthorn (Hippophaë rhamnoides L.)plant parts during annual growth cycle and estimation of their antioxidant potential[J].Open Chemistry,2014,12(11):1152-1161.
[34] SUVANTO J,TÄHTINEN P,VALKAMAA S,et al.Variability in foliar ellagitannins of Hippophaё rhamnoides L.and identification of a new ellagitannin,hippophaenin C[J].Journal of Agricultural and Food Chemistry,2018,66(3):613-620.
[35] CHIORCEA-PAQUIM A M,ENACHE T A,DE SOUZA GIL E,et al.Natural phenolic antioxidants electrochemistry:Towards a new food science methodology[J].Comprehensive Reviews in Food Science and Food Safety,2020,19(4):1680-1726.
[36] ZHENG W H,BAI H Y,HAN S,et al.Analysis on the constituents of branches,berries,and leaves of Hippophae rhamnoides L.by UHPLC-ESI-QTOF-MS and their anti-inflammatory activities[J].Natural Product Communications,2019,14(8):1934578X19871404.
[37] AIROUYUWA J O,MOSTAFA H,RIAZ A,et al.Natural deep eutectic solvents and microwave-assisted green extraction for efficient recovery of bioactive compounds from by-products of date fruit (Phoenix dactylifera L.)processing:Modeling,optimization,and phenolic characterization[J].Food and Bioprocess Technology,2023,16(4):824-843.
[38] KALLIO H,YANG W,LIU P Z,et al.Proanthocyanidins in wild sea buckthorn (Hippophaë rhamnoides)berries analyzed by reversed-phase,normal-phase,and hydrophilic interaction liquid chromatography with UV and MS detection[J].Journal of Agricultural and Food Chemistry,2014,62(31):7721-7729.
[39] WANG Y Q,SHAN Q,JIA Y P,et al.Ultrasound-assisted acidic natural deep eutectic solvent as a new strategy for extracting seabuckthorn leaf phenolics:Process optimization,compositional identification,and metabolic enzyme inhibition capacity[J].Food and Bioprocess Technology,2024,17(11):3670-3692.
[40] 廉永善,卢顺光.沙棘属植物生物学和化学[M].甘肃:甘肃科技出版社,2001. LIAN Y S,LU S G.Biology and chemistry of plants of the genus Hippophae[M].Gansu:Gansu Science and Technology Press,2001.
[41] 张欣.沙棘叶提取物对结直肠癌细胞HCT116的抑制作用[D].太原:山西大学,2020. ZHANG X.Inhibitory effect of anti-cancer extract of seabuckthorn leaves on HCT116 cells[D].Taiyuan:Shanxi University,2020.
[42] 丁金,铁芳芳,王洪伦.HPLC快速测定沙棘叶中的苯丙素与黄酮类成分[J].华西药学杂志,2023,38(5):548-551.
DING J,TIE F F,WANG H L.Rapid determination of phenylpropanoids and flavonoids components in the leaves of Hippophae rhamnoides by HPLC[J].West China Journal of Pharmaceutical Sciences,2023,38(5):548-551.
[43] 赵鑫丹,张东为,姜鑫,等.不同品种沙棘叶片和果实中酚酸类及黄酮类成分的比较[J].经济林研究,2024,42(4):247-256.
ZHAO X D,ZHANG D W,JIANG X,et al.Comparison of phenolic acids and flavonoids in leaves and berries of different varieties of seabuckthorn[J].Non-wood Forest Research,2024,42(4):247-256.
[44] 陈雏.青藏高原沙棘属植物资源与品质评价[D].成都:四川大学,2007. CHEN C.Resources and quality evaluation of genus Hippophae on the Qinghai-Tibetan Plateau[D].Chengdu:Sichuan University,2007.
[45] 胡建忠,张滨,高岩.我国主要野生沙棘果实的黄酮含量分析[J].青海农林科技,2021(4):8-12. HU J Z,ZHANG B,GAO Y.Analysis on total flavonoids of fruits from main natural seabuckthorn resources in China[J].Science and Technology of Qinghai Agriculture and Forestry,2021.
(4):8-12.
[46] 张东为,赵鑫丹,戈素芬,等.沙棘果实品质的主成分分析及综合评价[J].经济林研究,2023,41(2):1-10.
ZHANG D W,ZHAO X D,GE S F,et al.Principal component analysis and comprehensive evaluation of sea buckthorn berry quality[J].Non-wood Forest Research,2023,41(2):1-10.
[47] 谭亮,赵静,马家麟,等.青海玉树沙棘不同部位营养成分分析与营养价值评价[J].天然产物研究与开发,2018,30(5):807-816.
,899. TAN L,ZHAO J,MA J L,et al.Analysis of nutritional compositions and nutritional quality evaluation in different parts of Yushu Hippophae(Hippophae rhamnoides L.subsp.sinensis)[J].Natural Product Research and Development,2018,30(5):807-816,899.
[48] 戈素芬,张东为,赵鑫丹,等.5个杂交沙棘品种果实营养成分比较分析[J].食品工业科技,2022,43(22):328-335.
GE S F,ZHANG D W,ZHAO X D,et al.Analysis of nutrient compositions in five hybrid sea buckthorn varieties berries[J].Science and Technology of Food Industry,2022,43(22):328-335.
[49] 闫晓玲,郝莹,扈桂琪,等.黄土高塬沟壑区引进和杂交两类沙棘果实营养成分含量分析[J].中国水土保持,2025(3):56-58. YAN X L,HAO Y,HU G Q,et al.Study on nutritional content of two types of introduced and hybrid sea buckthorn fruits in the loess hilly and Gully Region[J].Soil and Water Conservation in China,2025.
(3):56-58.
[50] 唐克.沙棘不同部位总黄酮含量比较[J].黑龙江农业科学,2022(3):64-67. TANG K.Comparison of total flavonoids content in different parts of seabuckthorn[J].Heilongjiang Agricultural Sciences,2022.
(3):64-67.
[51] 唐克,吴雨蹊,王蕊,等.东北黑土区沙棘杂交品种(系)果实性状及营养成分比较[J].经济林研究,2023,41(3):286-295.
TANG K,WU Y X,WANG R,et al.Comparison of fruit characters and nutrient components of seabuckthorn hybrids(lines)in the black soil region of Northeast China[J].Non-wood Forest Research,2023,41(3):286-295.
[52] 张宏涛.肋果沙棘叶片黄酮类化合物含量与环境因子关系的研究[D].兰州:西北师范大学,2015. ZHANG H T.Study on the relationship between leaf flavonoids concentrationof Hippophae neurocarpa and environmental factors[D].Lanzhou:Northwest Normal University,2015.
[53] 赵文娟,马齐,陈卫锋,等.吴起野生沙棘不同部位总黄酮含量测定[J].河北林果研究,2010,25(3):252-254.
ZHAO W J,MA Q,CHEN W F,et al.Determination of total flavonoids in different parts of Wuqi wild Hippophae rhamnoides L[J].Hebei Journal of Forestry and Orchard Research,2010,25(3):252-254.
[54] 牟丹,唐楠,黄原林,等.沙棘、青海云杉、祁连圆柏总多酚含量的比较研究[J].湖北农业科学,2016,55(11):2879-2881.
MOU D,TANG N,HUANG Y L,et al.Comparison of the total polyphenol content of Hippohae rhamnoides,Picea crassifolia and Sabina przewalskii[J].Hubei Agricultural Sciences,2016,55(11):2879-2881.
[55] 郑文惠,白海英,王丽瑶,等.UPLC-QTOF-MS法分析沙棘果实、叶和枝的成分[J].中成药,2020,42(11):2940-2947.
ZHENG W H,BAI H Y,WANG L Y,et al.Analysis of constituents in the fruit,leaf and twig of Hippophae rhamnoides by UHPL-QTOF-MS[J].Chinese Traditional Patent Medicine,2020,42(11):2940-2947.
[56] 蔡爽,阮成江,杜维,等.沙棘叶片、果肉和种子中黄酮类成分的差异[J].植物资源与环境学报,2019,28(4):58-67.
CAI S,RUAN C J,DU W,et al.Difference in flavonoid constituents in leaf,pulp,and seed of Hippophaё rhamnoides[J].Journal of Plant Resources and Environment,2019,28(4):58-67.
[57] ALRUMAIHI F,ALMATROODI S A,ALHARBI H O A,et al.Pharmacological potential of kaempferol,a flavonoid in the management of pathogenesis via modulation of inflammation and other biological activities[J].Molecules,2024,29(9):2007.
[58] ZHU M T,SUN Y P,SU Y,et al.Luteolin:A promising multifunctional natural flavonoid for human diseases[J].Phytotherapy Research,2024,38(7):3417-3443.
[59] PISOSCHI A M,POP A,IORDACHE F,et al.Oxidative stress mitigation by antioxidants-An overview on their chemistry and influences on health status[J].European Journal of Medicinal Chemistry,2021,209:112891.
[60] LAVEFVE L,HOWARD L R,CARBONERO F.Berry polyphenols metabolism and impact on human gut microbiota and health[J].Food & Function,2020,11(1):45-65.
[61] ZEB A.Concept,mechanism,and applications of phenolic antioxidants in foods[J].Journal of Food Biochemistry,2020,44(9):e13394.
[62] KALINOWSKA M,GOŁEBIEWSKA E,S'WIDERSKI G,et al.Plant-derived and dietary hydroxybenzoic acids-a comprehensive study of structural,anti-/pro-oxidant,lipophilic,antimicrobial,and cytotoxic activity in MDA-MB-231 and MCF-7 cell lines[J].Nutrients,2021,13(9):3107.
[63] 付依依,王永霞,李月,等.大果沙棘中黄酮的体外抗炎及抗氧化活性研究[J].中国食品添加剂,2021,32(10):67-74.
FU Y Y,WANG Y X,LI Y,et al.Study on in vitro anti-inflammatory and antioxidant activities of flavonoids from sea buckthorn[J].China Food Additives,2021,32(10):67-74.
[64] XIANG Z D,GUAN H D,ZHAO X,et al.Dietary gallic acid as an antioxidant:A review of its food industry applications,health benefits,bioavailability,nano-delivery systems,and drug interactions[J].Food Research International,2024,180:114068.
[65] CHOWDHURY S,GHOSH S,DAS A K,et al.Ferulic acid protects hyperglycemia-induced kidney damage by regulating oxidative insult,inflammation and autophagy[J].Frontiers in Pharmacology,2019,10:27.
[66] AHMED O M,ELKOMY M H,FAHIM H I,et al.Rutin and quercetin counter doxorubicin-induced liver toxicity in wistar rats via their modulatory effects on inflammation,oxidative stress,apoptosis,and Nrf2[J].Oxidative Medicine and Cellular Longevity,2022,2022:2710607.
[67] ZHOU D H,WU Y,YAN H,et al.Gallic acid ameliorates calcium oxalate crystal-induced renal injury via upregulation of Nrf2/HO-1 in the mouse model of stone formation[J].Phytomedicine,2022,106:154429.
[68] LIU X Y,XING Y,YUEN M,et al.Anti-aging effect and mechanism of proanthocyanidins extracted from sea buckthorn on hydrogen peroxide-induced aging human skin fibroblasts[J].Antioxidants,2022,11(10):1900.
[69] LIU K S,LI W X,YUEN M,et al.Sea buckthorn proanthocyanidins are the protective agent of mitochondrial function in macrophages under oxidative stress[J].Frontiers in Pharmacology,2022,13:914146.
[70] LEE C Y,YOON S,MOON J O.Kaempferol suppresses carbon tetrachloride-induced liver damage in rats via the MAPKs/NF-κB and AMPK/Nrf2 signaling pathways[J].International Journal of Molecular Sciences,2023,24(8):6900.
[71] YAHFOUFI N,ALSADI N,JAMBI M,et al.The immunomodulatory and anti-inflammatory role of polyph-enols[J].Nutrients,2018,10(11):1618.
[72] MULATI A,MA S B,ZHANG H B,et al.Sea-buckthorn flavonoids alleviate high-fat and high-fructose diet-induced cognitive impairment by inhibiting insulin resistance and neuroinflammation[J].Journal of Agricultural and Food Chemistry,2020,68(21):5835-5846.
[73] MULATI A,ZHANG X,ZHAO T,et al.Isorhamnetin attenuates high-fat and high-fructose diet induced cognitive impairments and neuroinflammation by mediating MAPK and NFκB signaling pathways[J].Food & Function,2021,12(19):9261-9272.
[74] KONG X R,ZHAO L,HUANG H,et al.Isorhamnetin ameliorates hyperuricemia by regulating uric acid metabolism and alleviates renal inflammation through the PI3K/AKT/NF-κB signaling pathway[J].Food & Function,2025,16(7):2840-2856.
[75] ZOU Y,JIANG J L,LI Y Q,et al.Quercetin regulates microglia M1/M2 polarization and alleviates retinal inflammation via ERK/STAT3 pathway[J].Inflammation,2024,47(5):1616-1633.
[76] MAHMOUD A M,HUSSEIN O E,ABD EL-TWAB S M,et al.Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ,and suppression of NF-κB/NLRP3 inflammasome axis[J].Food & Function,2019,10(8):4593-4607.
[77] REN Q C,LI X H,LI Q Y,et al.Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke-induced airway inflammation[J].Phytotherapy Research,2019,33(8):2102-2117.
[78] OLSSON M E,GUSTAVSSON K E,ANDERSSON S,et al.Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels[J].Journal of Agricultural and Food Chemistry,2004,52(24):7264-7271.
[79] LI C H,LI J W,LI Y,et al.Isorhamnetin promotes MKN-45 gastric cancer cell apoptosis by inhibiting PI3K-mediated adaptive autophagy in a hypoxic environment[J].Journal of Agricultural and Food Chemistry,2021,69(29):8130-8143.
[80] HUANG W W,TSAI S C,PENG S F,et al.Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells[J].International Journal of Oncology,2013,42(6):2069-2077.
[81] CHOI J B,KIM J H,LEE H,et al.Reactive oxygen species and p53 mediated activation of p38 and caspases is critically involved in kaempferol induced apoptosis in colorectal cancer cells[J].Journal of Agricultural and Food Chemistry,2018,66(38):9960-9967.
[82] MICHAUD-LEVESQUE J,BOUSQUET-GAGNON N,BÉLIVEAU R.Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration[J].Experimental Cell Research,2012,318(8):925-935.
[83] PANG F X,DING S C,LI N,et al.Gallic acid mediates tumor-suppressive effects on osteosarcoma through the H19-Wnt/β-catenin regulatory axis[J].Journal of Orthopaedic Translation,2023,39:34-42.
[84] 崔米米.沙棘果结合态多酚抗结肠癌效应的活性成分及分子机制[D].太原:山西大学,2020. CUI M M.The anti-colon cancer active components and molecular mechanism of bound polyphenols from seabuckthorn berries[D].Taiyuan:Shanxi University,2020.
[85] WANG Y,NIE F Y,OUYANG J,et al.Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells[J].Tumour Biology,2014,35(10):9563-9569.
[86] CUI K L,WU H L,FAN J M,et al.The mixture of ferulic acid and P-coumaric acid suppresses colorectal cancer through lncRNA 495810/PKM2 mediated aerobic glycolysis[J].International Journal of Molecular Sciences,2022,23(20):12106.
[87] WU H L,LI C L,CUI M M,et al.Polyphenols from Hippophae rhamnoides suppressed colon cancer growth by regulating miRNA-mediated cell cycle arrest and apoptosis in vitro and in vivo[J].Journal of Functional Foods,2021,87:104780.
[88] 贾丛,杜亚蓉,孙坤.沙棘总黄酮抑制肺癌A549增殖和迁移作用及机理[J].天然产物研究与开发,2020,32(6):937-945.
,952. JIA C,DU Y R,SUN K.Study on effect and mechanism of total flavonoids of Hippophae in inhibiting proliferation and migration of lung cancer A549 cells[J].Natural Product Research and Development,2020,32(6):937-945,952.
[89] WANG L,WU H W,XIONG L,et al.Quercetin downregulates cyclooxygenase-2 expression and HIF-1α/VEGF signaling-related angiogenesis in a mouse model of abdominal aortic aneurysm[J].BioMed Research International,2020,2020(1):9485398.
[90] HAN S,YI Y W,KIM H,et al.Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells[J].
[91] KOUPENOVA M,CLANCY L,CORKREY H A,et al.Circulating platelets as mediators of immunity,inflammation,and thrombosis[J].Circulation Research,2018,122(2):337-351.
[92] KOUPENOVA M,KEHREL B E,CORKREY H A,et al.Thrombosis and platelets:An update[J].European Heart Journal,2017,38(11):785-791.
[93] RONDINA M T,WEYRICH A S,ZIMMERMAN G A.Platelets as cellular effectors of inflammation in vascular diseases[J].Circulation Research,2013,112(11):1506-1519.
[94] COCHAIN C,ZERNECKE A.Macrophages in vascular inflammation and atherosclerosis[J].Pflügers Archiv-European Journal of Physiology,2017,469(3):485-499.
[95] OLAS B,KONTEK B,MALINOWSKA P,et al.Hippophae rhamnoides L.fruits reduce the oxidative stress in human blood platelets and plasma[J].Oxidative Medicine and Cellular Longevity,2016,2016:4692486.
[96] 焦艳,谢世静,李喆.沙棘黄酮对大鼠动脉粥样硬化斑块的影响及作用机制[J].中国老年学杂志,2022,42(6):1472-1475.
JIAO Y,XIE S J,LI Z.Effect and mechanism of flavonoids from Hippophae rhamnoides on atherosclerotic plaque in rats[J].Chinese Journal of Gerontology,2022,42(6):1472-1475.
[97] ZHUO X Z,TIAN Y L,WEI Y D,et al.Flavone of Hippophae (H-flavone)lowers atherosclerotic risk factors via upregulation of the adipokine C1q/tumor necrosis factor-related protein 6 (CTRP6)in macrophages[J].Bioscience,Biotechnology,and Biochemistry,2019,83(11):2000-2007.
[98] BAO M H,LOU Y J.Flavonoids from seabuckthorn protect endothelial cells (EA.hy926)from oxidized low-density lipoprotein induced injuries via regulation of LOX-1 and ENOS expression[J].Journal of Cardiovascular Pharmacology,2006,48(1):834-841.
[99] LUO Y,SUN G B,DONG X,et al.Isorhamnetin attenuates atherosclerosis by inhibiting macrophage apoptosis via PI3K/AKT activation and HO-1 induction[J].PLoS One,2015,10(3):e0120259.
[100] HONG K X,WANG J T,KANG X P,et al.Ferulic acid and protocatechuic acid alleviate atherosclerosis by promoting UCP1 expression to inhibit the NLRP3-IL-1β signaling pathway[J].Food & Function,2025,16(1):40-53.
[101] WANG Y M,CHU T J,WAN R T,et al.Quercetin ameliorates atherosclerosis by inhibiting inflammation of vascular endothelial cells via Piezo1 channels[J].Phytomedicine,2024,132:155865.
[102] LI Q,HU X,XUAN Y,et al.Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO [J].Acta Biochimica et Biophysica Sinica,2018,50(3):246-53.
[103] 喻春红,卢霞泱,李玲玲,等.槲皮素介导IRF8/IFN-γ改善Hp感染诱导慢性萎缩性胃炎的机制研究[J].中华医院感染学杂志,2022,32(20):3073-3077.
YU C H,LU X Y,LI L L,et al.Mechanisms of quercetin-mediated IRF8/IFN-γ in improving chronic atrophic gastritis induced by Hp infection[J].Chinese Journal of Nosocomiology,2022,32(20):3073-3077.
[104] 周志华,李耀伟,王志琪,等.槲皮素配伍芹菜素对顺铂诱导人胃上皮细胞损伤作用的研究[J].湖南中医药大学学报,2022,42(5):772-778.
ZHOU Z H,LI Y W,WANG Z Q,et al.Effect of quercetin and apigenin on cisplatin-induced injury of human gastric epithelial cells[J].Journal of Hunan University of Chinese Medicine,2022,42(5):772-778.
[105] ANSARI M N,MISHRA R,AIER S,et al.Myricetin alleviates indomethacin-induced gastric ulcers in rats via antioxidant,anti-inflammatory and antiapoptotic mechanisms[J].Inflammopharmacology,2025,33(12):7535-47.
[106] 黄海波.没食子酸水凝胶构建及保护胃肠黏膜功能作用机理[D].大连:大连工业大学,2023. HUANG H B.Construction of gallic acid hydrogel and protective mechanism of gastrointestinal mucosa function[D].Dalian:Dalian Polytechnic University,2023.
[107] 贾子琴,朱瑞瑞,田连起,等.阿魏酸对幽门螺杆菌致胃炎小鼠胃黏膜Wnt/β-catenin信号通路的影响[J].药物评价研究,2024,47(1):109-114.
JIA Z Q,ZHU R R,TIAN L Q,et al.Effect of ferulic acid on Wnt/β-catenin signal pathway in mice with gastritis induced by Helicobacter pylori[J].Drug Evaluation Research,2024,47(1):109-114.
[108] ASADI G S,ABDIZADEH R,ABDIZADEH T.Investigation of a set of flavonoid compounds as Helicobacter pylori urease inhibitors:Insights from in silico studies[J].Journal of Biomolecular Structure and Dynamics,2025,43(5):2366-2388.
[109] PETTINI F,SPIGA O,FURINI S,et al.Electrophysiology,molecular modelling,and functional analysis of the effects of dietary quercetin and flavonoid analogues on Kir6.1 channels in rat stomach fundus smooth muscle[J].Biochemical Pharmacology,2024,220:115969.
[110] MEHRZADI S,HOSSEINI P,MEHRABANI M,et al.Attenuation of bleomycin-induced pulmonary fibrosis in wistar rats by combination treatment of two natural phenolic compounds:quercetin and gallic acid[J].Nutrition and Cancer,2021,73(10):2039-2049.
[111] ZHANG X X,XIE Y Z,CAI Y,et al.RNA-seq analysis and in vivo experiments identified the protective effect of kaempferol on idiopathic pulmonary fibrosis by regulating the PPARG/TNC signaling pathway to reduce ECM deposition[J].Food & Function,2024,15(24):12193-12209.
[112] ALATAWI F S,OMRAN A M E,RASHAD E,et al.Rutin attenuates bleomycin-induced acute lung injury via miR-9-5p mediated NF-κB signaling inhibition:Network pharmacology analysis and experimental evidence[J].Frontiers in Pharmacology,2025,16:1522690.
[113] ZHENG Q,TONG M,OU B Q,et al.Isorhamnetin protects against bleomycin-induced pulmonary fibrosis by inhibiting endoplasmic reticulum stress and epithelial-mesenchymal transition[J].International Journal of Molecular Medicine,2019,43(1):117-126.
[114] XIAO P T,LIU S Y,KUANG Y J,et al.Network pharmacology analysis and experimental validation to explore the mechanism of sea buckthorn flavonoids on hyperlipidemia[J].Journal of Ethnopharmacology,2021,264:113380.
[115] ZATTERALE F,LONGO M,NADERI J,et al.Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes[J].Frontiers in Physiology,2020,10:1607.
[116] KWON E Y,LEE J,JIN Y,et al.Seabuckthorn leaves extract and flavonoid glycosides extract from seabuckthorn leaves ameliorates adiposity,hepatic steatosis,insulin resistance,and inflammation in diet-induced obesity[J].Nutrients,2017,9(6):569.
[117] YANG X,WANG Q,PANG Z R,et al.Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity,hypertriglyceri-demia,and hepatic triglyceride accumulation in C57BL/6 mice[J].Pharmaceutical Biology,2017,55(1):1207-1214.
[118] BAOTHMAN O A,ZAMZAMI M A,TAHER I,et al.The role of gut microbiota in the development of obesity and diabetes[J].Lipids in Health and Disease,2016,15:108.
[119] LIU J H,HE Z Y,MA N,et al.Beneficial effects of dietary polyphenols on high-fat diet-induced obesity linking with modulation of gut microbiota[J].Journal of Agricultural and Food Chemistry,2020,68(1):33-47.
[120] LIU J Q,LIU Y H,HUANG C Q,et al.Quercetin-driven Akkermansia Muciniphila alleviates obesity by modulating bile acid metabolism via an ILA/m6A/CYP8B1 signaling[J].Advanced Science,2025,12(12):2412865.
[121] DOMÍNGUEZ-AVILA J A,VILLA-RODRIGUEZ J A,MONTIEL-HERRERA M,et al.Phenolic compounds promote diversity of gut microbiota and maintain colonic health[J].Digestive Diseases and Sciences,2021,66(10):3270-3289.
[122] LUO C H,WEI X C,SONG J,et al.Interactions between gut microbiota and polyphenols:New insights into the treatment of fatigue[J].Molecules,2022,27(21):7377.
[123] PLAMADA D,VODNAR D C.Polyphenols-gut microbiota interrelationship:A transition to a new generation of prebiotics[J].Nutrients,2021,14(1):137.
[124] WANG K W,XU Z Z,LIAO X J.Bioactive compounds,health benefits and functional food products of sea buckthorn:A review[J].Critical Reviews in Food Science and Nutrition,2022,62(24):6761-6782.
[125] ATTRI S,SHARMA K,RAIGOND P,et al.Colonic fermentation of polyphenolics from Seabuckthorn (Hippophae rhamnoides)berries:Assessment of effects on microbial diversity by principal component analysis[J].Food Research International,2018,105:324-332.
[126] XIA C X,GAO A X,ZHU Y,et al.Flavonoids from Seabuckthorn (Hippophae rhamnoides L.)restore CUMS-induced depressive disorder and regulate the gut microbiota in mice[J].Food & Function,2023,14(16):7426-7438.
[127] SU L J,ZENG Y P,LI G K,et al.Quercetin improves high-fat diet-induced obesity by modulating gut microbiota and metabolites in C57BL/6J mice[J].Phytotherapy Research,2022,36(12):4558-4572.
[128] PORRINI M,RISO P.Factors influencing the bioavailability of antioxidants in foods:A critical appraisal[J].Nutrition,Metabolism,and Cardiovascular Diseases,2008,18(10):647-650.
[129] TANG F H,WEI B Y,QIN C,et al.Enhancing the inhibitory activities of polyphenols in passion fruit peel on α-Amylase and α-Glucosidase via β-Glucosidase-producing Lactobacillus fermentation[J].Food Bioscience,2024,62:105005.
[130] SHEN Z Y,DAI J,YANG X Y,et al.Comparison of sea buckthorn fruit oil nanoemulsions stabilized by protein-polysaccharide conjugates prepared using β-glucan from various sources[J].Food Chemistry,2024,457:140098.
[131] PAN Y K,LI R,JING N N,et al.Isorhamnetin-lignin nanoparticles:Green preparation,characterization,remarkable bioavailability and long-lasting bioactivity in vivo[J].Food Bioscience,2025,69:106931.
[132] POLIA F,PASTOR-BELDA M,MARTÍNEZ-BLÁZQUEZ A,et al.Technological and biotechnological processes to enhance the bioavailability of dietary (poly)phenols in humans[J].Journal of Agricultural and Food Chemistry,2022,70(7):2092-2107.