JOURNAL OF LIGHT INDUSTRY

CN 41-1437/TS  ISSN 2096-1553

黏附性聚多巴胺@己脒定二羟乙基磺酸盐微胶囊的制备及其性能研究

付向荣 ,  郭清泉 ,  汤仲标 ,  赵海山

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付向荣, 郭清泉, 汤仲标, 等. 黏附性聚多巴胺@己脒定二羟乙基磺酸盐微胶囊的制备及其性能研究[J]. 轻工学报, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013
引用本文: 付向荣, 郭清泉, 汤仲标, 等. 黏附性聚多巴胺@己脒定二羟乙基磺酸盐微胶囊的制备及其性能研究[J]. 轻工学报, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013
shu
FU Xiangrong, GUO Qingquan, TANG Zhongbiao and et al. Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules[J]. Journal of Light Industry, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013
Citation: FU Xiangrong, GUO Qingquan, TANG Zhongbiao and et al. Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules[J]. Journal of Light Industry, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013
shu

黏附性聚多巴胺@己脒定二羟乙基磺酸盐微胶囊的制备及其性能研究

  • 1. 广东工业大学 轻工化工学院, 广东 广州 510006;

  • 2. 广州妮趣化妆品有限公司, 广东 广州 510660;

  • 3. 广东省人民医院, 广东 广州 510080

    • 作者简介: 付向荣(1995—),男,广东省韶关市人,广东工业大学硕士研究生,主要研究方向为化妆品功效和安全性评价。E-mail:xrfu@foxmail.com;

  • 基金项目: 国家自然科学基金项目（81903600）

  • 中图分类号: TS974;TQ658

Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules

  • 1. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;

  • 2. Guangzhou Niqu Cosmetics Co., Ltd., Guangzhou 510660, China;

  • 3. Guangdong Provincial People's Hospital, Guangzhou 510080, China

  • Received Date: 2022-01-24
    Accepted Date: 2022-11-23

    CLC number: TS974;TQ658

  • 摘要: 为提高去屑剂己脒定二羟乙基磺酸盐（HD）在湿润环境下的黏附性能，以W1/O/W2双重乳液为模板，合成具有黏附性的聚多巴胺@己脒定二羟乙基磺酸盐微胶囊（PDA@HD微胶囊），并对其形貌结构、载药性能、缓释性能、黏附性能及斑马鱼胚胎急性毒性进行研究。结果表明：PDA@HD微胶囊外观呈球状，有明显核壳结构，平均粒径为353 nm；通过提高双重乳液W1相中HD的质量浓度，可以显著提升PDA@HD微胶囊中HD的搭载率，当HD质量浓度为18 mg/mL，其搭载率为17.1%；HD在PDA@HD微胶囊中的释放表现出明显的pH依赖性，偏酸性环境更有利于HD的释放；PDA@HD微胶囊的黏附力提高明显，其平均黏附力（8.42 nN）约为HD （2.89 nN）的3倍；PDA@HD微胶囊的斑马鱼胚胎急性毒性有所降低，当PDA@HD微胶囊内的HD质量浓度为0.5 mg/mL时，斑马鱼胚胎发育至96 hpf仍无死亡。
    Abstract: Adhesive polydopamine nanocapsules containing hexamidine diisethionate (PDA@HD nanocapsules) were prepared using W1/O/W2 emulsion templating to enhance wet adhesion capacity of HD. Thereafter, the morphological structure, loading and release properties, adhesion properties and acute toxicity to zebrafish embryos of PDA were investigated. The results showed that the PDA@HD nanocapsules were spherical with a distinct core-shell structure whose average particle size was 353 nm. The loading ratio of PDA@HD nanocapsules could be effectively increased by increasing the concentration of HD in W1 phase of W1/O/W2 emulsion. Specifically, by increasing the concentration of HD to 18 mg/mL,the loading ratio of PDA@HD nanocapsules increased to 17.1%. The release of HD in PDA@HD nanocapsules exhibited a clear pH dependence and PDA@HD nanocapsules showed better release properties in acidic environment. The adhesion force of PDA@HD nanocapsules was effectively increased about 3 times that of HD. The PDA@HD nanocapsules reduced the acute toxicity to zebrafish embryos. When the concentration of HD in PDA@HD nanocapsules was 0.5 mg/mL, all zebrafish embryos survived till 96 hpf.
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  • 收稿日期:  2022-01-24
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付向荣, 郭清泉, 汤仲标, 等. 黏附性聚多巴胺@己脒定二羟乙基磺酸盐微胶囊的制备及其性能研究[J]. 轻工学报, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013
引用本文: 付向荣, 郭清泉, 汤仲标, 等. 黏附性聚多巴胺@己脒定二羟乙基磺酸盐微胶囊的制备及其性能研究[J]. 轻工学报, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013
shu
FU Xiangrong, GUO Qingquan, TANG Zhongbiao and et al. Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules[J]. Journal of Light Industry, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013
Citation: FU Xiangrong, GUO Qingquan, TANG Zhongbiao and et al. Preparation and properties of adhesive polydopamine@hexamidine diisethionate nanocapsules[J]. Journal of Light Industry, 2023, 38(1): 110-118. doi: 10.12187/2023.01.013
shu

黏附性聚多巴胺@己脒定二羟乙基磺酸盐微胶囊的制备及其性能研究

    作者简介:付向荣(1995—),男,广东省韶关市人,广东工业大学硕士研究生,主要研究方向为化妆品功效和安全性评价。E-mail:xrfu@foxmail.com
  • 1. 广东工业大学 轻工化工学院, 广东 广州 510006;
  • 2. 广州妮趣化妆品有限公司, 广东 广州 510660;
  • 3. 广东省人民医院, 广东 广州 510080
  • 收稿日期: 2022-01-24
  • 录用日期: 2022-11-23
基金项目:  国家自然科学基金项目（81903600）

摘要: 为提高去屑剂己脒定二羟乙基磺酸盐（HD）在湿润环境下的黏附性能，以W1/O/W2双重乳液为模板，合成具有黏附性的聚多巴胺@己脒定二羟乙基磺酸盐微胶囊（PDA@HD微胶囊），并对其形貌结构、载药性能、缓释性能、黏附性能及斑马鱼胚胎急性毒性进行研究。结果表明：PDA@HD微胶囊外观呈球状，有明显核壳结构，平均粒径为353 nm；通过提高双重乳液W1相中HD的质量浓度，可以显著提升PDA@HD微胶囊中HD的搭载率，当HD质量浓度为18 mg/mL，其搭载率为17.1%；HD在PDA@HD微胶囊中的释放表现出明显的pH依赖性，偏酸性环境更有利于HD的释放；PDA@HD微胶囊的黏附力提高明显，其平均黏附力（8.42 nN）约为HD （2.89 nN）的3倍；PDA@HD微胶囊的斑马鱼胚胎急性毒性有所降低，当PDA@HD微胶囊内的HD质量浓度为0.5 mg/mL时，斑马鱼胚胎发育至96 hpf仍无死亡。

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