噬菌体及其衍生物抗食源性致病菌生物被膜的研究进展

孙新城; 杜月霞; 周军; 杜婷婷; 秦金梦; 张思威; 张晓根

doi:10.12187/2025.05.005

October 2025

Article Contents

SUN Xincheng, DU Yuexia, ZHOU Jun, et al. Research progress of bacteriophages and their derivatives against foodborne pathogens biofilms[J]. Journal of Light Industry, 2025, 40(5): 37-43,54. doi: 10.12187/2025.05.005

Citation: SUN Xincheng, DU Yuexia, ZHOU Jun, et al. Research progress of bacteriophages and their derivatives against foodborne pathogens biofilms[J]. Journal of Light Industry, 2025, 40(5): 37-43,54. doi: 10.12187/2025.05.005 shu

Research progress of bacteriophages and their derivatives against foodborne pathogens biofilms

SUN Xincheng ^1,2,3,4 ,
DU Yuexia ¹ ,
ZHOU Jun ² ,
DU Tingting ¹ ,
QIN Jinmeng ¹ ,
ZHANG Siwei ¹ ,
ZHANG Xiaogen ¹

1. College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China;
2. Collaborative Innovation Center of Food Production and Safety, Henan Province, Zhengzhou 450001, China;
3. Zhengzhou University of Light Industry, Food Laboratory of Zhongyuan, Luohe 462300, China;
4. Key Laboratory of Cold Chain Food Processing and Safety Control, Ministry of Education(Cultivation), Zhengzhou 450001, China

Received Date: 2024-11-04
Accepted Date: 2025-03-12

Abstract

Biofilm (BF) is the predominant form of foodborne pathogenic bacteria during food processing. It has a complex structure, making it difficult for conventional disinfection and sterilization methods to eradicate it. Prevention and control strategies for biofilms are gradually becoming a research focus in the food field. Based on the severe situation in the prevention and control of foodborne pathogenic bacteria and the potential of bacteriophages as biological control agents, this review summarizes the formation process and main regulatory mechanisms of biofilms, as well as the research progress on bacteriophages and their derivatives, and the combination of bacteriophages and antibiotics in targeting biofilms of foodborne pathogenic bacteria. The formation process of biofilm generally includes the reversible adhesion stage, irreversible adhesion stage, early formation stage, maturation stage, and dispersion stage. Quorum sensing is the main factor that regulates biofilm formation. Bacteriophages can specifically target foodborne pathogenic bacteria. Their derivatives, lysin and holin, can degrade the peptidoglycan of bacteria, leading to bacterial cell lysis and the release of progeny bacteriophages. The combination of bacteriophages and antibiotics can produce a synergistic effect and improve the effect of prevention and control of biofilms formed by foodborne pathogenic bacteria. Future research will integrate the One Health concept, investigate the cross-transmission mechanism of biofilms in the “human-animal-environment” system from the fields of medicine, food, and environment, optimize the combination conditions of bacteriophages and antibiotics, and enhance the effect of multi-strategy synergistic prevention and control to better ensure food quality and safety.
- foodborne pathogenic bacteria,
- biofilm,
- phage,
- biological control agent,
- antibiotic
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Research progress of bacteriophages and their derivatives against foodborne pathogens biofilms

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