JOURNAL OF LIGHT INDUSTRY

CN 41-1437/TS  ISSN 2096-1553

Volume 26 Issue 6
December 2025
Article Contents
ZUO Lichao, BAO Yuanyuan, QU Zhaohui, et al. Research on the antioxidant and anti-photoaging properties of cerium oxide[J]. Journal of Light Industry, 2025, 40(6): 118-126. doi: 10.12187/2025.06.012
Citation: ZUO Lichao, BAO Yuanyuan, QU Zhaohui, et al. Research on the antioxidant and anti-photoaging properties of cerium oxide[J]. Journal of Light Industry, 2025, 40(6): 118-126. doi: 10.12187/2025.06.012 shu

Research on the antioxidant and anti-photoaging properties of cerium oxide

  • Corresponding author: WU Ke, wuke@btbu.edu.cn
  • Received Date: 2024-09-20
    Accepted Date: 2024-11-22
    Available Online: 2025-12-15
  • 【Objective】 To systematically evaluate the antioxidant properties of cerium oxide and elucidate its protective efficacy against UVA- and simulated sunlight-induced photoaging. 【Methods】 The antioxidant properties of cerium oxide were assessed through DPPH·, superoxide anion (O2-·), and hydroxyl radical (·OH) scavenging assays. Its recyclable antioxidant capacity was evaluated using an H2O2 recycling scavenging assay. In vitro photodamage models were established in human skin fibroblasts (HFF-1) using UVA irradiation and a solar simulator, followed by measurements of cellular viability and expression levels of type I (COL-Ⅰ) and type III (COL-Ⅲ) collagen. 【Results】 Cerium oxide exhibited significant antioxidant capacity. At a concentration of 6 mg/mL, it showed scavenging efficiencies of 83.42%, 30.29%, and 48.50% for DPPH·, O2-·, and ·OH radicals respectively. After three H2O2 recycling cycles, these efficiencies remained above 90%, confirming excellent recyclable antioxidant properties. Compared to the negative control, cerium oxide at 0.078 mg/mL increased HFF-1 cell viability by 38.78% under UVA irradiation. At this concentration, COL-Ⅰ expression showed a 77.0-fold increase relative to the control group. In simulated sunlight-induced damage, cerium oxide at 0.039 mg/mL increased COL-Ⅲ expression to 14.06 ng/mL, representing a 1.5-fold increase compared to the negative control group. 【Conclusion】 Cerium oxide demonstrates potent recyclable radical scavenging properties. By upregulating COL-Ⅰ and COL-Ⅲ expression, it significantly mitigates UVA- and simulated sunlight-induced photoaging damage in HFF-1 cells, indicating considerable potential for development as a novel antioxidant and anti-photoaging active ingredient.
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    1. [1]

      TRAUTINGER F.Mechanisms of photodamage of the skin and its functional consequences for skin ageing[J].Clinical and Experimental Dermatology,2001,26(7):573-577.

    2. [2]

      DARÉ R G,KOLANTHAI E,NEAL C J,et al.Cerium oxide nanoparticles conjugated with tannic acid prevent UVB-induced oxidative stress in fibroblasts:Evidence of a promising anti-photodamage agent[J].Antioxidants,2023,12(1):190.

    3. [3]

      MASUI T,YAMAMOTO M,SAKATA T,et al.Synthesis of BN-coated CeO2 fine powder as a new UV blocking material[J].Journal of Materials Chemistry,2000,10(2):353-357.

    4. [4]

      HUDSON L,RASHDAN E,BONN C A,et al.Individual and combined effects of the infrared,visible,and ultraviolet light components of solar radiation on damage biomarkers in human skin cells[J].The FASEB Journal,2020,34(3):3874-3883.

    5. [5]

      WU Z L,CHENG Y Q,TAO F,et al.Direct neutron spectroscopy observation of cerium hydride species on a cerium oxide catalyst[J].Journal of the American Chemical Society,2017,139(28):9721-9727.

    6. [6]

      ZHU Y C,LI C T,LIU X,et al.Cobalt-doped cerium dioxide enhances interfacial synergistic catalysis for boosting the oxidation of toluene[J].Separation and Purification Technology,2024,328:124993.

    7. [7]

      XU K,ZHANG H,DENG W Q,et al.Self-hydrating of a ceria-based catalyst enables efficient operation of solid oxide fuel cells on liquid fuels[J].Science Bulletin,2023,68(21):2574-2582.

    8. [8]

      YOUSAF SHAH M A K,LU Y Z,MUSHTAQ N,et al.Doped ceria electrolyte rich in oxygen vacancies for boosting the fuel cell performance of LT-CFCs[J].International Journal of Hydrogen Energy,2023,48(33):12474-12484.

    9. [9]

      ZHANG M Z,ZHAI X Y,MA T F,et al.Sequential therapy for bone regeneration by cerium oxide-reinforced 3D-printed bioactive glass scaffolds[J].ACS Nano,2023,17(5):4433-4444.

    10. [10]

      CHEN C D,CUI Y Y,LI X P,et al.Novel ceria/graphene oxide composite abrasives for chemical mechanical polishing[J].Ceramics International,2024,50(15):26325-26333.

    11. [11]

      ÁLVAREZ-ASENCIO R,CORKERY R W,AHNIYAZ A.Solventless synthesis of cerium oxide nanoparticles and their application in UV protective clear coatings[J].RSC Advances,2020,10(25):14818-14825.

    12. [12]

      FENG Y,ZHANG D,CHEN X Y,et al.Confined-synthesis of ceria in tubular nanoclays for UV protection and anti-biofilm application[J].Advanced Functional Materials,2024,34(7):2307157.

    13. [13]

      ESTES L M,SINGHA P,SINGH S,et al.Characterization of a nitric oxide (NO) donor molecule and cerium oxide nanoparticle (CNP) interactions and their synergistic antimicrobial potential for biomedical applications[J].Journal of Colloid and Interface Science,2021,586:163-177.

    14. [14]

      KANG D W,KIM C K,JEONG H G,et al.Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage[J].Nano Research,2017,10(8):2743-2760.

    15. [15]

      吕广明,王艳杰,刘瑞,等.纳米氧化铈的抗氧化生物应用[J].中国科学:化学,2013,43(10):1309-1321.
      LYU G M,WANG Y J,LIU R,et al.The application of nanoceria in the bio-antioxidation[J].Scientia Sinica Chimica,2013,43(10):1309-1321.

    16. [16]

      THAKUR N,MANNA P,DAS J.Synthesis and biomedical applications of nanoceria,a redox active nanoparticle[J].Journal of Nanobiotechnology,2019,17(1):84.

    17. [17]

      KIM Y G,LEE Y,LEE N,et al.Ceria-based therapeutic antioxidants for biomedical applications[J].Advanced Materials,2024,36(10):2210819.

    18. [18]

      XU H,YANG S J,LIU Y X et al.Polyvinyl alcohol-encapsulated cerium oxide nanospheres composite nanofiber membrane for enhanced antioxidant and antibacterial applications[J].Journal of Rare Earths,2025,43(9),1944-1954.

    19. [19]

      PEREZ J M,ASATI A,NATH S,et al.Synthesis of biocompatible dextran-coated nanoceria with pH-dependent antioxidant properties[J].Small,2008,4(5):552-556.

    20. [20]

      中华人民共和国国家质量监督检验检疫总局、中国国家标准化管理委员会.粮油检验 粮食、油料的过氧化氢酶活动度的测定:GB/T 5522—2008[S].北京:中国标准出版社,2009. General Administration of Quality Supervision,Inspection and Quarantine of the People’s Republic of China and Standardization Administration of China.Grain and oil inspection-Determination of catalase activity in grains and oilseeds:GB/T 5522—2008[S].Beijing:China Standards Press,2009.

    21. [21]

    22. [22]

      萧华山,何文锦,傅文庆,等.一种用分光光度计检测氧自由基的新方法[J].生物化学与生物物理进展,1999,26 (2):180-182.
      XIAO H S,HE W J,FU W Q,et al.A spectrophotometer method testing oxygen radicals[J].Progress in Biochemistry and Biophysics,1999,26(2):180-182.

    23. [23]

      薛山,肖夏,陈舒怡,等.双响应面法结合Matlab法优化葡萄籽多酚提取工艺及羟自由基清除率评价[J].食品工业科技,2020,41(3):160-167.
      XUE S,XIAO X,CHEN S Y,et al.Dual response surface method combined with Matlab to optimize extraction process of grape seed polyphenols and the evaluation on its hydroxyl radical scavenging rate[J].Science and Technology of Food Industry,2020,41(3):160-167.

    24. [24]

      WEN W J,CHEN J W,DING L G,et al.Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy[J].Archives of Biochemistry and Biophysics,2018,657:31-40.

    25. [25]

      黄莺莺,张翠平,张言政,等.蜂胶抗光老化功效[J].福建农林大学学报(自然科学版),2020,49(1):80-85.
      HUANG Y Y,ZHANG C P,ZHANG Y Z et al.Anti-photoaging function of Propolis[J].Journal of Fujian Agriculture and Forestry University (Natural Science Edition),2020,49(1):80-85.

    26. [26]

      徐晓浩.石斛多糖对皮肤光损伤的修复作用及其机制研究[D].长春:长春中医药大学,2023. XU X H.Research on the repair effect and mechanism of dendrobium polysaccharides on skin photodamage[D].Chang Chun:Changchun University of Chinese Medicine, 2023.

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