喀什“新新2号”核桃油组成特征及其在HepG2细胞中调节脂质代谢与抗氧化活性评价

郑巧文; 孙怡宁; 邓玮亮; 陈小乐; 陈坤锥; 覃威铭; 申迎宾; 张磊

doi:10.12187/2026.03.004

喀什“新新2号”核桃油组成特征及其在HepG2细胞中调节脂质代谢与抗氧化活性评价

1. 广州大学生命科学学院, 广东广州 510006;
2. 新疆农业大学林学与风景园林学院, 新疆乌鲁木齐 830052;
3. 中国农业大学食品科学与营养工程学院, 北京 100083

作者简介: 郑巧文(1998—),女,广东省广州市人,广州大学硕士研究生,主要研究方向为食品营养与健康。E-mail:qiaowenzheng0307@163.com;

通讯作者: 张磊,zlei_xj@sina.com

基金项目: 新疆维吾尔自治区重大科技专项课题项目(2022A02004-1)
中央引导地方科技发展项目(ZYYD2024CG22)
中图分类号: TS225.1

Compositional characteristics of Kashgar ‘Xinxin 2’ walnut oil and evaluation of its lipid eetabolism-regulating and antioxidant activities in HepG2 cells

1. School of Life Sciences, Guangzhou University, Guangzhou 510006, China;
2. College of Forestry and Landscape Architecture, Xinjiang Agricultural University, Ürümqi 830052, China;
3. College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China

Corresponding author: ZHANG Lei, zlei_xj@sina.com

Received Date: 2025-10-10
Accepted Date: 2025-11-28

CLC number: TS225.1

摘要: 【目的】研究喀什“新新2号”核桃油的化学组成,并评估其调节脂质代谢与抗氧化的潜力。【方法】采用色谱技术分析喀什“新新2号”核桃油的脂肪酸组成与微量活性成分含量,构建HepG2细胞脂肪堆积模型,通过油红O染色观察细胞内脂滴形成情况,并检测相关脂质代谢与氧化应激指标。【结果】喀什“新新2号”核桃油中不饱和脂肪酸的相对含量为91.01%,其中亚油酸、油酸和α-亚麻酸的相对含量分别为62.70%、14.30%和14.01%,ω6/ω3脂肪酸比例为4.48∶1;其富含生育酚(27.06 mg/100 g)、植物甾醇(332.00 mg/100 g)、角鲨烯(86.00 mg/100 g)和多酚(6.79 mg/100 g)。高剂量(500 μg/mL)核桃油能显著抑制HepG2细胞内脂滴形成,对总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和丙二醛(MDA)的抑制率分别为42.19%、42.21%、71.96%和76.57%。而高密度脂蛋白胆固醇(HDL-C)含量、超氧化物歧化酶(SOD)活性和谷胱甘肽过氧化物酶(GSH-Px)活性则分别提高至模型组的4.55倍、3.15倍和5.10倍。【结论】喀什“新新2号”核桃油富含不饱和脂肪酸及多种微量活性成分,在细胞水平上表现出显著的脂质代谢调节与抗氧化潜力,有望作为一款具有调节脂质代谢功能的新型健康食用油。
- 核桃油 /
- 组成特征 /
- 脂质代谢 /
- 抗氧化活性 /
- HepG2细胞
Abstract: 【Objective】 This study aimed to investigate the chemical composition of Kashgar ‘Xinxin 2’ walnut oil and evaluate its potential to regulate lipid metabolism and exert antioxidant effects. 【Methods】 Chromatographic techniques were used to analyze the fatty acid profile and the contents of minor bioactive components in Kashgar ‘Xinxin 2’ walnut oil. A lipid accumulation model was established in HepG2 cells. Intracellular lipid droplet formation was observed by oil red O staining, and relevant lipid metabolism and oxidative stress markers were determined. 【Results】 The relative content of unsaturated fatty acids in Kashgar ‘Xinxin 2’ walnut oil was 91.01%, with linoleic acid, oleic acid, and α-linolenic acid accounting for 62.70%, 14.30%, and 14.01%, respectively, yielding an ω6/ω3 ratio of 4.48∶1. The oil was also rich in tocopherols (27.06 mg/100 g), phytosterols (332.00 mg/100 g), squalene (86.00 mg/100 g), and polyphenols (6.79 mg/100 g). Treatment with a high dose (500 μg/mL) of the walnut oil significantly inhibited intracellular lipid droplet formation in HepG2 cells, with inhibition rates of 42.19%, 42.21%, 71.96%, and 76.57% for total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and malondialdehyde (MDA), respectively. Conversely, the levels of high-density lipoprotein cholesterol (HDL-C) and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) increased to 4.55, 3.15, and 5.10 times those of the model group, respectively. 【Conclusion】 Kashgar ‘Xinxin 2’ walnut oil is rich in unsaturated fatty acids and various minor bioactive components, and it demonstrates significant potential in regulating lipid metabolism and exerting antioxidant effects at the cellular level, suggesting its promise as a novel healthy edible oil capable of modulating lipid metabolism.
- walnut oil /
- compositional characteristic /
- lipid metabolism /
- antioxidant activity /
- HepG2 cells
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沈阳化工大学材料科学与工程学院沈阳 110142

喀什“新新2号”核桃油组成特征及其在HepG2细胞中调节脂质代谢与抗氧化活性评价

作者简介: 郑巧文(1998—),女,广东省广州市人,广州大学硕士研究生,主要研究方向为食品营养与健康。E-mail:qiaowenzheng0307@163.com;

通讯作者: 张磊,zlei_xj@sina.com

Compositional characteristics of Kashgar ‘Xinxin 2’ walnut oil and evaluation of its lipid eetabolism-regulating and antioxidant activities in HepG2 cells

Corresponding author: ZHANG Lei, zlei_xj@sina.com

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通讯作者: 陈斌, bchen63@163.com

喀什“新新2号”核桃油组成特征及其在HepG2细胞中调节脂质代谢与抗氧化活性评价

作者简介:郑巧文(1998—),女,广东省广州市人,广州大学硕士研究生,主要研究方向为食品营养与健康。E-mail:qiaowenzheng0307@163.com

通讯作者: 张磊, zlei_xj@sina.com

English Abstract

Compositional characteristics of Kashgar ‘Xinxin 2’ walnut oil and evaluation of its lipid eetabolism-regulating and antioxidant activities in HepG2 cells

Corresponding author: ZHANG Lei, zlei_xj@sina.com

目录

喀什“新新2号”核桃油组成特征及其在HepG2细胞中调节脂质代谢与抗氧化活性评价

作者简介: 郑巧文(1998—),女,广东省广州市人,广州大学硕士研究生,主要研究方向为食品营养与健康。E-mail:qiaowenzheng0307@163.com;

通讯作者: 张磊,zlei_xj@sina.com

Compositional characteristics of Kashgar ‘Xinxin 2’ walnut oil and evaluation of its lipid eetabolism-regulating and antioxidant activities in HepG2 cells

Corresponding author: ZHANG Lei, zlei_xj@sina.com

计量

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通讯作者: 陈斌, bchen63@163.com

喀什“新新2号”核桃油组成特征及其在HepG2细胞中调节脂质代谢与抗氧化活性评价

作者简介:郑巧文(1998—),女,广东省广州市人,广州大学硕士研究生,主要研究方向为食品营养与健康。E-mail:qiaowenzheng0307@163.com

通讯作者: 张磊, zlei_xj@sina.com

English Abstract

Compositional characteristics of Kashgar ‘Xinxin 2’ walnut oil and evaluation of its lipid eetabolism-regulating and antioxidant activities in HepG2 cells

Corresponding author: ZHANG Lei, zlei_xj@sina.com

目录