植物多糖缓解结肠炎的作用机制与构效关系研究进展

王尧; 颜锐坤; 梁雪梅; 叶利经; 吴帅凯; 钟琼; 刘莉莉; 赵国军

doi:10.12187/2026.05.003

植物多糖缓解结肠炎的作用机制与构效关系研究进展

广州医科大学附属清远医院(清远市人民医院), 广东清远 511518

作者简介: 王尧(1994—),男,山西省长治市人,广州医科大学附属清远医院博士后,主要研究方向为天然产物的功能评价及机制探究。E-mail:wy844798360@163.com;

通讯作者: 赵国军,zhaoguojun@gzhmu.edu.cn

基金项目: 广东省自然科学基金面上项目(2024A1515012850)
中图分类号: TS201.6

Research progress on the mechanisms and structure-activity relationships of plant polysaccharides in alleviating colitis

The Affiliated Qingyuan Hospital of Guangzhou Medical University (Qingyuan People's Hospital), Qingyuan 511518, China

Corresponding author: Zhao Guojun, zhaoguojun@gzhmu.edu.cn

Received Date: 2025-12-29
Accepted Date: 2026-02-25

CLC number: TS201.6

摘要: 基于植物多糖在结肠炎干预中的研究基础,综述近年来植物多糖抗结肠炎作用机制及构效关系的研究进展。植物多糖可通过调控NLRP3炎症小体、NF-κB、MAPK、NRF2/HO-1、PI3K/Akt、JAK/STAT等信号通路,重塑肠道菌群,促进短链脂肪酸等代谢物生成,并增强肠黏膜屏障功能,从而缓解实验性结肠炎。植物多糖的抗结肠炎活性与其相对分子质量、单糖组成、主链结构、空间构象、糖醛酸含量、结构修饰等密切相关,但不同研究在原料来源、提取纯化、结构表征、动物模型条件等方面存在较大差异,尚难以建立具有普适性的构效规律。目前相关研究仍以细胞和动物实验为主,临床研究不足。未来应加强同源多糖的结构分级、定向修饰与构象调控研究,结合多组学、肠道菌群代谢和屏障功能评价解析作用链条,并依据标准化方案开展临床研究,以推动植物多糖在功能性食品及结肠炎防治中的转化应用。
- 植物多糖 /
- 结肠炎 /
- 作用机制 /
- 肠道菌群 /
- 构效关系
Abstract: Based on the accumulating evidence on plant polysaccharides in colitis intervention, this review summarizes recent advances in their anti-colitis mechanisms and structure-activity relationships. Current evidence indicates that plant polysaccharides can ameliorate experimental colitis by modulating signaling pathways involving the NLRP3 inflammasome, NF-κB, MAPK, NRF2/HO-1, PI3K/Akt, and JAK/STAT; reshaping the gut microbiota; promoting the production of microbial metabolites such as short-chain fatty acids (SCFAs); and enhancing the intestinal mucosal barrier. Their anti-colitis activities are associated with molecular weight, monosaccharide composition, backbone structure, spatial conformation, uronic acid content, and structural modification. However, substantial heterogeneity in raw materials, extraction and purification procedures, structural characterization, and animal models makes it difficult to establish generalizable structure-activity relationships. Current evidence is still dominated by cell and animal studies, while clinical studies remain limited. Future studies should prioritize structure-guided fractionation, targeted modification, and conformational regulation of homologous polysaccharides; integrate multi-omics with gut microbial metabolism and barrier-function assessment to clarify the underlying mechanisms; and conduct clinical studies according to standardized protocols to promote the translational application of plant polysaccharides in functional foods and in the prevention and treatment of colitis.
- plant polysaccharide /
- colitis /
- mechanism of action /
- gut microbiota /
- structure-activity relationship
1. [1]
  Wang X J,Huang S W,Zhang M L,et al.Gegen Qinlian decoction activates AhR/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice[J].Journal of Ethnopharmacology,2023,302:115919.
2. [2]
  Kobayashi T,Siegmund B,Le Berre C,et al.Ulcerative colitis[J].Nature Reviews Disease Primers,2020,6(1):74.
3. [3]
  Nakase H,Sato N,Mizuno N,et al.The influence of cytokines on the complex pathology of ulcerative colitis[J].Autoimmunity Reviews,2022,21(3):103017.
4. [4]
  Li J W,Niu C X,Ai H H,et al.TSP50 attenuates DSS-induced colitis by regulating TGF-β signaling mediated maintenance of intestinal mucosal barrier integrity[J].Advanced Science,2024,11(11):e2305893.
5. [5]
  Dong D F,Su T X,Chen W,et al.Clostridioides difficile aggravates dextran sulfate solution (DSS)-induced colitis by shaping the gut microbiota and promoting neutrophil recruitment[J].Gut Microbes,2023,15(1):2192478.
6. [6]
  Zhao Y X,Luan H F,Gao H,et al.Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/chronic ulcerative colitis via bidirectionally modulating dysregulated Notch signaling[J].Phytomedicine,2020,68:153182.
7. [7]
  Armuzzi A,Liguori G.Quality of life in patients with moderate to severe ulcerative colitis and the impact of treatment:a narrative review[J].Digestive and Liver Disease,2021,53(7):803-808.
8. [8]
  Wisniewski A,Kirchgesner J,Seksik P,et al.Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines[J].United European Gastroenterology Journal,2020,8(3):303-313.
9. [9]
  Yuan D,Li C,Huang Q,et al.Current advances in the anti-inflammatory effects and mechanisms of natural polysaccharides[J].Critical Reviews in Food Science and Nutrition,2023,63(22):5890-5910.
10. [10]
  冀晓龙,郭建行,田静源,等.植物多糖降解方法及降解产物特性研究进展[J].轻工学报,2023,38(3):55-62.
  Ji X L,Guo J H,Tian J Y,et al.Research progress on degradation methods and product properties of plant polysaccharides[J].Journal of Light Industry,2023,38(3):55-62.
11. [11]
  冀晓龙,王治雯,潘飞兵,等.槟榔多糖对Caco-2细胞氧化损伤的保护作用[J].轻工学报,2022,37(6):18-24.
  Ji X L,Wang Z W,Pan F B,et al.Protective effect of Areca catechu L.polysaccharide on Caco-2 cells oxidative injury[J].Journal of Light Industry,2022,37(6):18-24.
12. [12]
  Xiao T S.Innate immunity and inflammation[J].Cellular and Molecular Immunology,2017,14(1):1-3.
13. [13]
  Fu J N,Wu H.Structural mechanisms of NLRP3 inflammasome assembly and activation[J].Annual Review of Immunology,2023,41:301-316.
14. [14]
  Xian H X,Watari K,Sanchez-Lopez E,et al.Oxidized DNA fragments exit mitochondria via mPTP-and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling[J].Immunity,2022,55(8):1370-1385.e8.
15. [15]
  Wang F H,Liang Q Q,Ma Y X,et al.Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway[J].Free Radical Biology and Medicine,2022,182:171-181.
16. [16]
  Bauer C,Duewell P,Mayer C,et al.Colitis induced in mice with dextran sulfate sodium (DSS)is mediated by the NLRP3 inflammasome[J].Gut,2010,59(9):1192-1199.
17. [17]
  Li H,Feng J X,Liu C,et al.Polysaccharides from an edible mushroom,Hericium erinaceus,alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis[J].International Journal of Biological Macromolecules,2024,267:131251.
18. [18]
  Pan X L,Wang H Y,Zheng Z M,et al.Pectic polysaccharide from Smilax china L.ameliorated ulcerative colitis by inhibiting the galectin-3/NLRP3 inflammasome pathway[J].Carbohydrate Polymers,2022,277:118864.
19. [19]
  Simovic Markovic B,Nikolic A,Gazdic M,et al.Galectin-3 plays an important pro-inflammatory role in the induction phase of acute colitis by promoting activation of NLRP3 inflammasome and production of IL-1β in macrophages[J].Journal of Crohn’s & Colitis,2016,10(5):593-606.
20. [20]
  Montaño D E,Hartung S,Wich M,et al.The TLR-NF-κB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera,a causative agent of invasive mucormycosis[J].Frontiers in Immunology,2022,13:882921.
21. [21]
  McDaniel D K,Eden K,Ringel V M,et al.Emerging roles for noncanonical NF-κB signaling in the modulation of inflammatory bowel disease pathobiology[J].Inflammatory Bowel Diseases,2016,22(9):2265-2279.
22. [22]
  Lv(Lyu)J,Zhang Y H,Tian Z Q,et al.Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-κB activation[J].International Journal of Biological Macromolecules,2017,98:723-729.
23. [23]
  Cui L,Wang W,Luo Y,et al.Polysaccharide from Scutellaria baicalensis Georgi ameliorates colitis via suppressing NF-κB signaling and NLRP3 inflammasome activation[J].International Journal of Biological Macromolecules,2019,132:393-405.
24. [24]
  Guo C L,Wang Y Q,Zhang S H,et al.Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism[J].International Journal of Biological Macromolecules,2021,181:357-368.
25. [25]
  Park M Y,Ha S E,Kim H H,et al.Scutellarein inhibits LPS-induced inflammation through NF-κB/MAPKs signaling pathway in RAW264.7 cells[J].Molecules,2022,27(12):3782.
26. [26]
  Gomez-Osuna A,Calatrava V,Galvan A,et al.Identification of the MAPK cascade and its relationship with nitrogen metabolism in the green Alga Chlamydomonas reinhardtii[J].International Journal of Molecular Sciences,2020,21(10):3417.
27. [27]
  Wen Z Y,Li M Y,Meng J,et al.Genome-wide identification of the MAPK and MAPKK gene families in response to cold stress in Prunus mume[J].International Journal of Molecular Sciences,2023,24(10):8829.
28. [28]
  Li C L,Li Z Q,Zheng Y.Natural products targeting the MAPK signaling pathway:potential options for ulcerative colitis treatment[J].Frontiers in Pharmacology,2025,16:1721584.
29. [29]
  Feng X J,Du C,Wang C L.Structural characterization of polysaccharide from yellow sweet potato and ameliorates DSS-induced mice colitis by active GPR41/MEK/ERK 1/2 signaling pathway[J].International Journal of Biological Macromolecules,2021,192:278-288.
30. [30]
  Vukelić I,Detel D,Bati Ač ić L,et al.Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation,apoptosis and autophagy[J].Food and Chemical Toxicology,2020,145:111680.
31. [31]
  Kim M H,Kang S G,Park J H,et al.Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice[J].Gastroenterology,2013,145(2):396-406.e10.
32. [32]
  Han J M,Lee E K,Gong S Y,et al.Sparassis crispa exerts anti-inflammatory activity via suppression of TLR-mediated NF-κB and MAPK signaling pathways in LPS-induced RAW264.7 macrophage cells[J].Journal of Ethnopharmacology,2019,231:10-18.
33. [33]
  Wu M L,Wang Q,Li X D,et al.Gut microbiota-derived 5-hydroxyindoleacetic acid from pumpkin polysaccharides supplementation alleviates colitis via MAPKs-PPARγ/NF-κB inhibition[J].International Journal of Biological Macromolecules,2024,264:130385.
34. [34]
  Feng Y Q,Chen S M,Song Y T,et al.A novel Sagittaria sagittifolia L.polysaccharides mitigate DSS-induced colitis via modulation of gut microbiota and MAPK/NF-κB signaling pathways[J].International Journal of Biological Macromolecules,2024,254(Pt 3):127835.
35. [35]
  Shu L,Fu H J,Pi A W,et al.Protective effect of andrographolide against ulcerative colitis by activating Nrf2/HO-1 mediated antioxidant response[J].Frontiers in Pharmacology,2024,15:1424219.
36. [36]
  Liu M L,Wen H X,Zuo L G,et al.Bryostatin-1 attenuates intestinal ischemia/reperfusion-induced intestinal barrier dysfunction,inflammation,and oxidative stress via activation of Nrf2/HO-1 signaling[J].FASEB Journal,2023,37(6):e22948.
37. [37]
  Sun Y Y,Zhu H J,Zhao R Y,et al.Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2/HO-1 pathway in MCAO mice[J].Redox Biology,2023,66:102852.
38. [38]
  Liu C,Hua H Y,Zhu H K,et al.Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism[J].International Journal of Biological Macromolecules,2021,185:804-812.
39. [39]
  Yan S K,Yin L J,Dong R.Inhibition of IEC-6 cell proliferation and the mechanism of ulcerative colitis in C57BL/6 mice by dandelion root polysaccharides[J].Foods,2023,12(20):3800.
40. [40]
  Krimmer S G,Schlessinger J.Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants[J].Proceedings of the National Academy of Sciences of the United States of America,2022,119(50):e2218237119.
41. [41]
  Dornan G L,Burke J E.Molecular mechanisms of human disease mediated by oncogenic and primary immunodeficiency mutations in class IA phosphoinositide 3-kinases[J].Frontiers in Immunology,2018,9:575.
42. [42]
  Niu S Y,Zhang Y.Targeting the PI3K/Akt pathway for the treatment of ulcerative colitis:integrative regulatory features of traditional Chinese medicine[J].Frontiers in Pharmacology,2025,16:1620138.
43. [43]
  Lin X B,Lan M Y,Xu C,et al.Peach gum polysaccharides promotes epithelial proliferation to attenuate ulcerative colitis by PI3K/AKT pathway[J].Journal of Functional Foods,2023,107:105662.
44. [44]
  Zhang Z,Cui Y S,Ouyang H,et al.Radix Pueraria Lobata polysaccharide relieved DSS-induced ulcerative colitis through modulating PI3K signaling[J].Journal of Functional Foods,2023,104:105514.
45. [45]
  Cheng X X,Zhu Y H,Huang J H,et al.A neutral polysaccharide from Persicaria hydropiper (L.)Spach ameliorates lipopolysaccharide-induced intestinal barrier injury via regulating the gut microbiota and modulating AKT/PI3K/mTOR and MAPK signaling pathways[J].Journal of Ethnopharmacology,2024,320:117403.
46. [46]
  Long D,Mao C H,Zhang W,et al.Natural products for the treatment of ulcerative colitis:focus on the JAK/STAT pathway[J].Frontiers in Immunology,2025,16:1538302.
47. [47]
  Li Y G,Yu P,Fu W W,et al.Polysaccharides from Panax ginseng C.A.Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice[J].Journal of Functional Foods,2022,91:105013.
48. [48]
  Chen Y F,Zheng J J,Qu C,et al.Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance[J].Artificial Cells,Nanomedicine,and Biotechnology,2019,47(1):757-766.
49. [49]
  Fan L N,Qi Y D,Qu S W,et al.B.adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling[J].Gut Microbes,2021,13(1):1826746.
50. [50]
  Yang Y P,Zheng X J,Wang Y Q,et al.Human fecal microbiota transplantation reduces the susceptibility to dextran sulfate sodium-induced germ-free mouse colitis[J].Frontiers in Immunology,2022,13:836542.
51. [51]
  Zeng X J,Li X J,Yue Y,et al.Ameliorative effect of Saccharomyces cerevisiae JKSP39 on Fusobacterium nucleatum and dextran sulfate sodium-induced colitis mouse model[J].Journal of Agricultural and Food Chemistry,2022,70(44):14179-14192.
52. [52]
  Mu Z Y,Yang Y J,Xia Y J,et al.Probiotic yeast BR14 ameliorates DSS-induced colitis by restoring the gut barrier and adjusting the intestinal microbiota[J].Food & Function,2021,12(18):8386-8398.
53. [53]
  Li Y Q,Xu H T,Zhou L Y,et al.Bifidobacterium breve protects the intestinal epithelium and mitigates inflammation in colitis via regulating the gut microbiota-cholic acid pathway[J].Journal of Agricultural and Food Chemistry,2024,72(7):3572-3583.
54. [54]
  Al-Sadi R,Nighot P,Nighot M,et al.Lactobacillus acidophilus induces a strain-specific and toll-like receptor 2-dependent enhancement of intestinal epithelial tight junction barrier and protection against intestinal inflammation[J].The American Journal of Pathology,2021,191(5):872-884.
55. [55]
  Chen Y,Chen H Q,Ding J H,et al.Bifidobacterium longum ameliorates dextran sulfate sodium-induced colitis by producing conjugated linoleic acid,protecting intestinal mechanical barrier,restoring unbalanced gut microbiota,and regulating the toll-like receptor-4/nuclear factor-κB signaling pathway[J].Journal of Agricultural and Food Chemistry,2021,69(48):14593-14608.
56. [56]
  Liu L,Liang L P,Yang C H,et al.Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway[J].Gut Microbes,2021,13(1):1902718.
57. [57]
  Seishima J,Iida N,Kitamura K,et al.Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host[J].Genome Biology,2019,20(1):252.
58. [58]
  Nie C,Zhao Y Y,Wang P J,et al.Momordica charantia Polysaccharide intervention ameliorates the symptoms of dextran sulfate sodium (DSS)-induced colitis by modulating gut microbiota and inhibiting inflammation[J].Journal of Functional Foods,2024,112:105970.
59. [59]
  Yang Y R,Zhang Y W,Song J P,et al.Bergamot polysaccharides relieve DSS-induced ulcerative colitis via regulating the gut microbiota and metabolites[J].International Journal of Biological Macromolecules,2023,253:127335.
60. [60]
  Yang J Y,Chen S Y,Wu Y H,et al.Ameliorative effect of buckwheat polysaccharides on colitis via regulation of the gut microbiota[J].International Journal of Biological Macromolecules,2023,227:872-883.
61. [61]
  Deleu S,Arnauts K,Deprez L,et al.High acetate concentration protects intestinal barrier and exerts anti-inflammatory effects in organoid-derived epithelial monolayer cultures from patients with ulcerative colitis[J].International Journal of Molecular Sciences,2023,24(1):768.
62. [62]
  Zhang H Q,Hao Z H,Zhang R Y,et al.Artemisia argyi polyphenols Attenuates DSS-induced colitis in mice by regulating the structural composition of gut microbiota[J].Phytomedicine,2024,132:155897.
63. [63]
  Parada Venegas D,de la Fuente M K,Landskron G,et al.Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases[J].Frontiers in Immunology,2019,10:277.
64. [64]
  Bai Y,Zhou X J,Zhao J B,et al.Sources of dietary fiber affect the SCFA production and absorption in the hindgut of growing pigs[J].Frontiers in Nutrition,2021,8:719935.
65. [65]
  Lin Y,Lv(Lyu) Y S,Mao Z A,et al.Polysaccharides from Tetrastigma Hemsleyanum Diels et Gilg ameliorated inflammatory bowel disease by rebuilding the intestinal mucosal barrier and inhibiting inflammation through the SCFA-GPR41/43 signaling pathway[J].International Journal of Biological Macromolecules,2023,250:126167.
66. [66]
  Zhou R,Huang K W,Chen S M,et al.Zhilining Formula alleviates DSS-induced colitis through suppressing inflammation and gut barrier dysfunction via the AHR/NF-κBp65 axis[J].Phytomedicine,2024,129:155571.
67. [67]
  Moonwiriyakit A,Pathomthongtaweechai N,Steinhagen P R,et al.Tight junctions:from molecules to gastrointestinal diseases[J].Tissue Barriers,2023,11(2):2077620.
68. [68]
  Song M S,Zhang Z,Li Y N,et al.Midgut microbiota affects the intestinal barrier by producing short-chain fatty acids in Apostichopus japonicus[J].Frontiers in Microbiology,2023,14:1263731.
69. [69]
  Hao W,Chen Z J,Yuan Q,et al.Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation[J].International Journal of Biological Macromolecules,2022,219:730-739.
70. [70]
  Ji Z H,He S,Xie W Y,et al.Agaricus blazei polysaccharide alleviates DSS-induced colitis in mice by modulating intestinal barrier and remodeling metabolism[J].Nutrients,2023,15(23):4877.
71. [71]
  Yao D B,Dai W L,Dong M,et al.MUC₂ and related bacterial factors:therapeutic targets for ulcerative colitis[J].eBioMedicine,2021,74:103751.
72. [72]
  Xiao H Y,Li H L,Wen Y F,et al.Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function[J].International Journal of Biological Macromolecules,2021,180:633-642.
73. [73]
  Liu W,Wang L J,Yuan Q,et al.Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism[J].Food & Function,2024,15(3):1191-1207.
74. [74]
  Huo Z Q,Li J X,Li X F,et al.Functional fractions of Astragalus polysaccharides as a potential prebiotic to alleviate ulcerative colitis[J].International Journal of Biological Macromolecules,2024,271:132580.
75. [75]
  Tian B M,Geng Y,Xu T R,et al.Digestive characteristics of Hericium erinaceus polysaccharides and their positive effects on fecal microbiota of male and female volunteers during in vitro fermentation[J].Frontiers in Nutrition,2022,9:858585.
76. [76]
  Gong H,Gan X N,Qin B Y,et al.Structural characteristics of steamed Polygonatum cyrtonema polysaccharide and its bioactivity on colitis via improving the intestinal barrier and modifying the gut microbiota[J].Carbohydrate Polymers,2024,327:121669.
77. [77]
  Wei S X,Wang L F,Chen X D,et al.Polysaccharide from Boletus aereus ameliorates DSS-induced colitis in mice by regulating the MANF/MUC₂ signaling and gut microbiota[J].International Journal of Biological Macromolecules,2024,266:131232.
78. [78]
  Zhao Y N,Chen H,Li W T,et al.Selenium-containing tea polysaccharides ameliorate DSS-induced ulcerative colitis via enhancing the intestinal barrier and regulating the gut microbiota[J].International Journal of Biological Macromolecules,2022,209:356-366.
79. [79]
  Zhang Q,Wu G R,Shen S M,et al.Dioscoreae persimilis polysaccharide ameliorates DSS-induced ulcerative colitis in mice through modulation of microbiota composition[J].Journal of Holistic Integrative Pharmacy,2023,4(2):157-165.
80. [80]
  Wei C Y,Yao L,Zhang Y,et al.Structural characterization of peach gum polysaccharide and its effects on the regulation of DSS-induced acute colitis[J].International Journal of Biological Macromolecules,2023,225:1224-1234.
81. [81]
  Sun Y Q,Huo J X,Zhong S,et al.Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii[J].Carbohydrate Polymers,2021,268:118214.
82. [82]
  Zhang Y,Wu Z J,Liu J X,et al.Identification of the core active structure of a Dendrobium officinale polysaccharide and its protective effect against dextran sulfate sodium-induced colitis via alleviating gut microbiota dysbiosis[J].Food Research International,2020,137:109641.
83. [83]
  Jin M Y,Wang Y X,Yang X B,et al.Structure characterization of a polysaccharide extracted from noni (Morinda citrifolia L.)and its protective effect against DSS-induced bowel disease in mice[J].Food Hydrocolloids,2019,90:189-197.
84. [84]
  Wan L,Qian C,Yang C M,et al.Ginseng polysaccharides ameliorate ulcerative colitis via regulating gut microbiota and tryptophan metabolism[J].International Journal of Biological Macromolecules,2024,265:130822.
85. [85]
  Huang L L,Sun Q,Li Q H,et al.Screening and characterization of an anti-inflammatory pectic polysaccharide from Cucurbita moschata Duch[J].International Journal of Biological Macromolecules,2024,264:130510.
86. [86]
  Zheng L,Ma Y H,Zhang Y J,et al.Increased antioxidant activity and improved structural characterization of sulfuric acid-treated stepwise degraded polysaccharides from Pholiota nameko PN-01[J].International Journal of Biological Macromolecules,2021,166:1220-1229.
87. [87]
  Du J L,Wang B L,Chen J H,et al.Extraction,characterization and bioactivities of novel purified polysaccharides from Baphicacanthis Cusiae Rhizoma et Radix[J].International Journal of Biological Macromolecules,2016,93:879-888.
88. [88]
  Liu Y,Zhang Y Q,Mei N J,et al.Three acidic polysaccharides derived from sour jujube seeds protect intestinal epithelial barrier function in LPS induced Caco-2 cell inflammation model[J].International Journal of Biological Macromolecules,2023,240:124435.
89. [89]
  Li S J,Li M X,Yue H,et al.Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains[J].Carbohydrate Polymers,2018,186:168-175.
90. [90]
  Li Z W,Du Z M,Wang Y W,et al.Chemical modification,characterization,and activity changes of land plant polysaccharides:a review[J].Polymers,2022,14(19):4161.
91. [91]
  Qin L,Xu H,Cao J H,et al.Alleviative effects of sulfated polysaccharide from Ishige okamurae against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota[J].International Journal of Biological Macromolecules,2024,268:131915.
92. [92]
  V Brito T,Barros F C N,Silva R O,et al.Sulfated polysaccharide from the marine algae Hypnea musciformis inhibits TNBS-induced intestinal damage in rats[J].Carbohydrate Polymers,2016,151:957-964.
93. [93]
  Li C,Jiao Y K,Shen S M,et al.Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress[J].Biomedicine & Pharmacotherapy,2023,169:115941.
1. [1]
  甘晓锟 , 陈坤锥 , 申迎宾 , 张磊 , 李湛 . 鹿茸菇多糖对免疫抑制小鼠免疫及肠道菌群的作用. 轻工学报, 2025, 40(6): 54-66. doi: 10.12187/2025.06.006
2. [2]
  焦丽丽 , 孙茜文 , 任婷 , 姜子烨 , 李波 . 人参果果胶体外消化和酵解特性研究. 轻工学报, 2026, 41(2): 21-31. doi: 10.12187/2026.02.002
3. [3]
  郭向阳 , 王璐璐 , 马景可 , 金珂婷 . 超声波降解多糖的作用表现、影响因素及机理研究进展. 轻工学报, 2025, 40(4): 41-51. doi: 10.12187/2025.04.005
4. [4]
  李良玉 , 张思影 , 李雪静 , 曹荣安 , 王坤 , 王菲菲 . 毛蜂窝菌粗多糖超声波辅助提取工艺优化及其体外生物活性研究. 轻工学报, 2026, 41(5): 1-12. doi: 10.12187/2026.05.001
5. [5]
  尹思睿 , 冯娇 , 杨晓宇 , 李良 . 植物蛋白复配对植物肉品质的影响. 轻工学报, 2024, 39(5): 18-28. doi: 10.12187/2024.05.003
6. [6]
  贾晨阳 , 张帆 , 刘兰茜 , 王光路 , 杨雪鹏 . 一株高耐受粗甘油枯草芽孢杆菌的分子机制研究. 轻工学报, 2025, 40(5): 44-54. doi: 10.12187/2025.05.006
7. [7]
  王子朝 , 舒志涵 , 郑毅 , 陈庆功 . 艾草多糖结构特征及抗氧化活性研究. 轻工学报, 2026, 41(5): 13-24. doi: 10.12187/2026.05.002
8. [8]
  张丽华 , 陈云莉 , 石勇 , 李顺峰 , 查蒙蒙 , 李昌文 , 纵伟 , 王小媛 . 植物乳杆菌发酵对红枣汁挥发性香气成分的影响. 轻工学报, 2024, 0(0): -.
9. [9]
  张丽华 , 刘世豪 , 石勇 , 李顺峰 , 方萱钰 , 陈云莉 , 纵伟 . 超声波诱导植物乳杆菌对发酵红枣汁品质的影响. 轻工学报, 2025, 0(0): -.
10. [10]
  张丽华 , 刘世豪 , 石勇 , 李顺峰 , 方萱钰 , 陈云莉 , 纵伟 . 超声波诱导植物乳杆菌对发酵红枣汁品质的影响. 轻工学报, 2025, 40(5): 1-10. doi: 10.12187/2025.05.001
11. [11]
  蒋纬 , 胡颖 , 朱振元 . 阳荷多糖提取工艺优化及其生物活性研究. 轻工学报, 2025, 40(4): 10-19. doi: 10.12187/2025.04.002
12. [12]
  李雅欣 , 罗敏 , 刘元福 , 孙全娇 , 黄俊铭 , 文建霞 , 杜文雅 , 张良 . 低共熔溶剂提取川明参多糖工艺优化与结构表征. 轻工学报, 2026, 41(1): 47-58. doi: 10.12187/2026.01.005
13. [13]
  张峻松 , 胡云怿 , 张新龙 , 王嘉奇 , 于国锋 , 梁淼 , 张骁 . 秋葵多糖在烟草中的保润性能及热解行为研究. 轻工学报, 2026, 41(1): 81-89,126. doi: 10.12187/2026.01.008
14. [14]
  孙学锋 , 师东方 , 金强 , 冀研敏 , 朱远洋 , 朱鲜艳 , 朱海波 , 郑晓云 . 加热卷烟用薄荷香精关键香气分析及其相互作用研究. 轻工学报, 2026, 41(5): 119-131. doi: 10.12187/2026.05.011
15. [15]
  万帅 , 刘前进 , 席高磊 , 陈彪 , 张洁 , 臧翔宇 , 芦昶彤 , 李耀光 . 烟气基质下烤甜香韵天然香料与合成香料间香味相互作用研究. 轻工学报, 2026, 41(3): 88-97. doi: 10.12187/2026.03.009
16. [16]
  李亮辉 , 徐芳 , 邓曦 , 吴艺圆 , 林少玲 . 姜黄素-酪胺共晶介导的光动力技术对冷藏三文鱼的保鲜作用. 轻工学报, 2026, 0(0): -.
17. [17]
  游敏 , 付金存 , 王远 , 王震 , 陈思蒙 , 李斌 , 邓国栋 , 吴恺 . 烟丝形态特性与细支卷烟填充密度均匀性关系研究. 轻工学报, 2025, 40(1): 75-81. doi: 10.12187/2025.01.009
18. [18]
  程传玲 , 杨淑萌 , 鲁平 , 楚文娟 , 张小娜 , 韩路 , 崔春 , 王豪礼 . 烟灰宏观黏度因子与卷烟包灰性能的关系研究. 轻工学报, 2025, 0(0): -.
19. [19]
  程传玲 , 杨淑萌 , 鲁平 , 楚文娟 , 张小娜 , 韩路 , 崔春 , 王豪礼 . 烟灰宏观黏度因子与卷烟包灰性能的关系研究. 轻工学报, 2025, 40(5): 110-117. doi: 10.12187/2025.05.013
20. [20]
  周军 , 黄俊清 , 杜婷婷 , 秦金梦 , 张思威 , 孙世彪 , 孙新城 . 1株沙门氏菌噬菌体的分离鉴定及其抑菌效果研究. 轻工学报, 2026, 41(1): 59-68. doi: 10.12187/2026.01.006

点击查看大图

计量

PDF下载量: 0
文章访问数: 250
引证文献数: 0

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

植物多糖缓解结肠炎的作用机制与构效关系研究进展

作者简介: 王尧(1994—),男,山西省长治市人,广州医科大学附属清远医院博士后,主要研究方向为天然产物的功能评价及机制探究。E-mail:wy844798360@163.com;

通讯作者: 赵国军,zhaoguojun@gzhmu.edu.cn

Research progress on the mechanisms and structure-activity relationships of plant polysaccharides in alleviating colitis

Corresponding author: Zhao Guojun, zhaoguojun@gzhmu.edu.cn

计量

通讯作者: 陈斌, bchen63@163.com

植物多糖缓解结肠炎的作用机制与构效关系研究进展

作者简介:王尧(1994—),男,山西省长治市人,广州医科大学附属清远医院博士后,主要研究方向为天然产物的功能评价及机制探究。E-mail:wy844798360@163.com

通讯作者: 赵国军, zhaoguojun@gzhmu.edu.cn

English Abstract

Research progress on the mechanisms and structure-activity relationships of plant polysaccharides in alleviating colitis

Corresponding author: Zhao Guojun, zhaoguojun@gzhmu.edu.cn

目录

植物多糖缓解结肠炎的作用机制与构效关系研究进展

作者简介: 王尧(1994—),男,山西省长治市人,广州医科大学附属清远医院博士后,主要研究方向为天然产物的功能评价及机制探究。E-mail:wy844798360@163.com;

通讯作者: 赵国军,zhaoguojun@gzhmu.edu.cn

Research progress on the mechanisms and structure-activity relationships of plant polysaccharides in alleviating colitis

Corresponding author: Zhao Guojun, zhaoguojun@gzhmu.edu.cn

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

植物多糖缓解结肠炎的作用机制与构效关系研究进展

作者简介:王尧(1994—),男,山西省长治市人,广州医科大学附属清远医院博士后,主要研究方向为天然产物的功能评价及机制探究。E-mail:wy844798360@163.com

通讯作者: 赵国军, zhaoguojun@gzhmu.edu.cn

English Abstract

Research progress on the mechanisms and structure-activity relationships of plant polysaccharides in alleviating colitis

Corresponding author: Zhao Guojun, zhaoguojun@gzhmu.edu.cn

目录