Preparation of immobilized halohydrin dehalogenase and the stability testing of catalytic systhesis ATS-5

Abstract

Keywords:
• (R)-4-cyano-3-hydroxybutyric acid ethyl,
• immobilization,
• halohydrin dehaloge-nase,
• catalytic stability

References

1. [1]

   江红,吴永健.阿托伐他汀治疗新进展[J].心血管病学进展,2004(5):335.
   

2. [2]

   丁洪,吴林森,陈永乐.四种半合成及全合成他汀类药物的研究与开发[J].药学进展,1999(2):65.
   

3. [3]

   KUMAR Y,KUMAR SMD,SATHYANARAYANA S.Process for the production of atorvastatin calcium in amorphous form:20090216029[P].2009-08-27.

4. [4]

   杨宽,余丽丽,姚琳,等.调血脂药物阿伐他汀的合成路线[J].化工科技,2013(4):71.
   

5. [5]

   MOTHANA B,BOYD R J.A density functional theory study of the mechanism of the Paal-Knorr pyrrole synthesis[J].Journal of Molecular Structure Theo Chem,2007,811(1-3):97.

6. [6]

   金勇,吴坚平,徐刚,等.有机相酶催化氨解反应拆分制备(R)-4-氯-3-羟基丁酸乙酯[J].有机化学,2006(10):1384.
   

7. [7]

   钟萍,孙志浩.生物催化不对称还原方法生产(S)-4-氯-3-羟基丁酸乙酯[J].过程工程学报,2005(6):665.
   

8. [8]

   LEE H W,KIM Y M,YOO C L,et al.An efficient method for the large-scale synthesis of atorvastatin calcium[J].Biomolecules & Therapeutics,2008,16(1):28.

9. [9]

   DESANTIS G,WONG K,FARWELL B,et al.Creation of a productive,highly enantioselective nitrilase through gene site saturation mutagenesis (GSSM)[J].Journal of the Hmerican Chemical Society,2003,125(38):11476.

10. [10]

    WANG L J,LI C X,NI Y,et al.Highly efficient synthesis of chiral alcohols with a novel NADH-dependent reductase from Streptomyces coelicolor[J].Biovesource Technology,2011,102(14):7023.

11. [11]

    何玉财,陶志成,张丹平,等.(R)-4-氯-3-羟基丁酸乙酯及其衍生物的生物合成方法:104988085[P].2015-10-21.
    

12. [12]

    曹林秋.载体固定化酶:原理、应用和设计[M].北京:化学工业出版社,2008.
    

13. [13]

    OGINO C,NEGI Y,MATSUMIYA T,et al.Purification,characterization and sequence determination of phospholipase D secreted by streptoverticillium cinnamoneum[J].Journal of Biochemistry,1999,125(2):263.

14. [14]

    WANG G J,HOLLINGSWORTH R I.Synthetic routes to l-carnitine and l-gamma-amino-beta-hydroxybutyric acid from (S)-3-hydroxybutyrolactone by functional group priority switching[J].Tetrahedron Asymmetr,1999,10(10):1895.

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