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动物源性食品兽药多残留检测中基质净化与液相色谱-质谱联用技术研究进展

季宝成 ,  杨澜瑞 ,  韩雨 ,  白艳红 ,  许旭

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季宝成, 杨澜瑞, 韩雨, 等. 动物源性食品兽药多残留检测中基质净化与液相色谱-质谱联用技术研究进展[J]. 轻工学报, 2023, 38(5): 8-16. doi: 10.12187/2023.05.002
引用本文: 季宝成, 杨澜瑞, 韩雨, 等. 动物源性食品兽药多残留检测中基质净化与液相色谱-质谱联用技术研究进展[J]. 轻工学报, 2023, 38(5): 8-16. doi: 10.12187/2023.05.002
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JI Baocheng, YANG Lanrui, HAN Yu, et al. Research progress on matrix purification combined with LC-MS method for the detection of veterinary drug residues in animal-derived foods[J]. Journal of Light Industry, 2023, 38(5): 8-16. doi: 10.12187/2023.05.002
Citation: JI Baocheng, YANG Lanrui, HAN Yu, et al. Research progress on matrix purification combined with LC-MS method for the detection of veterinary drug residues in animal-derived foods[J]. Journal of Light Industry, 2023, 38(5): 8-16. doi: 10.12187/2023.05.002
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动物源性食品兽药多残留检测中基质净化与液相色谱-质谱联用技术研究进展

  • 1. 郑州轻工业大学 食品与生物工程学院, 河南 郑州 450001;

  • 2. 河南省冷链食品安全质量安全控制重点实验室, 河南 郑州 450001;

  • 3. 食品生产与安全河南省协同创新中心, 河南 郑州 450001

    • 作者简介: 季宝成(1990-),男,河南省信阳市人,郑州轻工业大学讲师,博士,主要研究方向为食品质量与安全检测。E-mail:jibaocheng@zzuli.edu.cn;

  • 基金项目: 国家自然科学基金青年基金项目(31901767,32202174)
    河南省重大公益专项项目(201300110100)
    郑州轻工业大学博士科研基金资助项目(13501050067,13501050079)

  • 中图分类号: TS207.3

Research progress on matrix purification combined with LC-MS method for the detection of veterinary drug residues in animal-derived foods

  • 1. College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China;

  • 2. Henan Key Laboratory of Cold Chain Food Safety Quality and Safety Control, Zhengzhou 450001, China;

  • 3. Henan Collaborative Innovation Center for Food production and Safety, Zhengzhou 450001, China

  • Received Date: 2022-08-29
    Accepted Date: 2022-10-26

    CLC number: TS207.3

  • 摘要: 对液相色谱-质谱(Liquid Chromatography-Mass Spectrometry,LC-MS)联用技术结合不同动物源基质净化技术在兽药多残留检测的研究进展及其应用状况进行了综述,指出,液-液萃取、分散液-液微萃取、固相萃取、固相微萃取、分散固相萃取、磁性固相萃取技术在肉类、蛋类、奶类及其制品等不同动物源性食品中的应用较广泛,但仍存在一定程度的局限性,如液-液萃取基质选择性弱、分散液-液微萃取适用对象有限、固相萃取耗时较长、固相微萃取重现性差、分散固相萃取净化效率适中等。未来可就构建多种类兽药残留同步净化方法、开发食品源基质特异性高效净化材料及增强基质净化过程快捷、自动化程度等方面进行深入研究,以期进一步推动LC-MS联用技术在动物源性食品兽药多残留检测中的应用。
    Abstract: The research progress in matrix purification combined with liquid chromatography-mass spectrometry (LC-MS) method as well as their applications in determination of veterinary drugs in animal-derived foods was reviewed. Among various matrix purification methods, liquid liquid extraction (LLE), dispersed liquid liquid microextraction (DLLME), solid phase extraction (SPE), solid phase microextraction (SPME), dispersed solid phase extraction (DSPE), and magnetic solid phase extraction (MSPE) are mostly widely used in different animal derived foods such as meat, eggs, milk, and their products. However, there are still some limitations, such as weak matrix selectivity of LLE, limited applicability of DLLME, moderate purification efficiency DPSE, poor reproducibility of SPME, and time-consuming operation of SPE. In the future, the detection technology of veterinary drugs in various animal-derived foods could be further studied in terms of establishing simultaneous purification methods for various kinds of veterinary drugs, developing novel and efficient matrix-based purification materials, and enhancing convenience and automation in matrix purification process to meet the urgent needs in screening of multi-residues of veterinary drugs in animal-derived foods.
    1. [1]

      JIA J Z,ZHANG H X,QU J Y,et al.Immunosensor of nitrofuran antibiotics and their metabolites in animal-derived foods: A review[J].Frontiers in Chemistry,2022,10:813666.

    2. [2]

      ALFARIS N A,ALTAMIMI J Z,ALOTHMAN Z A,et al.Development of a sensitive liquid-liquid extraction and ultra-performance liquid chromatography-tandem mass spectrometry method for the analysis of carbaryl residues in fresh vegetables sold in Riyadh[J].Journal of King Saud University Science,2020,32(4):2414-2418.

    3. [3]

      MINGLE C L,DARKO G,BORQUAYE L S,et al.Veterinary drug residues in beef,chicken,and egg from ghana[J].Chemistry Africa-A Journal of the Tunisian Chemical Society,2021,4(2): 339-348.

    4. [4]

      LI S L,ZHANG Q Y,CHEN M D,et al.Determination of veterinary drug residues in food of animal origin: Sample preparation methods and analytical techniques[J].Journal of Liquid Chromatography & Related Technologies,2020,43(17/18):701-724.

    5. [5]

      LAN C,YIN D,YANG Z C,et al.Determination of six macrolide antibiotics in chicken sample by liquid chromatography-tandem mass spectrometry based on solid phase extraction[J].Journal of Analytical Methods in Chemistry,2019,2019:1-13.

    6. [6]

      张建伟,孟蕾,吴志明,等.牛奶中兽药残留检测前处理技术研究进展[J].食品安全质量检测学报,2021,12(22):8745-8751.

    7. [7]

      中华人民共和国国家卫生健康委员会,中华人民共和国农业农村部,国家市场监督管理总局.食品安全国家标准 食品中兽药最大残留限量:GB 31650-2019 [S].北京:中国标准出版社,2019.

    8. [8]

      KANDA M,NAKAJIMA T,HAYASHI H,et al.Multi-residue determination of polar veterinary drugs in livestock and fishery products by liquid chromatography/tandem mass spectrometry[J].Journal of Aoac International,2015,98(1):230-247.

    9. [9]

      DESMARCHELIER A,FAN K L,TIEN M M,et al.Determination of 105 antibiotic,anti-inflammatory,antiparasitic agents and tranquilizers by LC-MS/MS based on an acidic QuEChERS-like extraction[J].Food Additives and Contaminants Part A(Chemistry Analysis Control Exposure & Risk Assessment),2018,35(4):646-660.

    10. [10]

      KARRAR E,AHMED I A M,MANZOOR M F,et al.Lipid-soluble vitamins from dairy products:Extraction, purification, and analytical techniques[J].Food Chemistry,2021,373:131436.

    11. [11]

      JUNG H N,PARK D H,YOO K H,et al.Simultaneous quantification of 12 veterinary drug residues in fishery products using liquid chromatography-tandem mass spectrometry[J].Food Chemistry,2021,348:129105.

    12. [12]

      WANG Q F,CHEN R J,SHATNER W,et al.State-of-the-art on the technique of dispersive liquid-liquid microextraction[J].Ultrasonics Sonochemistry,2019,51:369-377.

    13. [13]

      VERA-CANDIOTI L,TEGLIA C M,CAMARA M S.Dispersive liquid-liquid microextraction of quinolones in porcine blood:Optimization of extraction procedure and CE separation using experimental design[J]. Electrophoresis,2016,37(20):2670-2677.

    14. [14]

      GAO J J,WANG H,QU J G,et al.Development and optimization of a naphthoic acid-based ionic liquid as a "non-organic solvent microextraction" for the determination of tetracycline antibiotics in milk and chicken eggs[J].Food Chemistry,2017,215:138-148.

    15. [15]

      JING W Q,WANG J Q,KUIPERS B,et al.Recent applications of graphene and graphene-based materials as sorbents in trace analysis[J].Trac-Trends in Analytical Chemistry,2021,137:116212.

    16. [16]

      LIU P Y,ZHANG H,MI Z J,et al.Determination of 11 sulfonamides in pork by two-step liquid-liquid extraction-solid phase extraction purification coupled with high performance liquid chromatography-tandem mass spectrometry[J].Chinese Journal of Chromatography,2019,37(10):1098-1104.

    17. [17]

      PLOTKA-WASYLKA J,SZCZEPANSKA N,DE LA GUARDIA M,et al.Miniaturized solid-phase extraction techniques[J].Trac-Trends in Analytical Chemistry,2015,73:19-38.

    18. [18]

      唐超,刘振平,肖琦,等.固相微萃取技术在农药残留检测中的应用进展[J].化工管理,2020(35):21-22.

    19. [19]

      KHALED A,SINGH V,PAWLISZYN J.Comparison of solid-phase microextraction to solvent extraction and QuEChERS for quantitative analysis of veterinary drug residues in chicken and beef matrices[J].Journal of Agricultural and Food Chemistry,2019,67(46):12663-12669.

    20. [20]

      PENG C Y,ZHANG S W,WU C L,et al.In-tube solid phase microextraction and determination of ractopamine in pork muscle samples using amide group modified polysaccharide-silica hybrid monolith as sorbent prior to HPLC analysis[J].Food Chemistry,2021,355:129662.

    21. [21]

      郑文慧,叶江雷,王秀彬,等.分散固相萃取法在农药残留检测中应用的进展[J].分析仪器,2011(4):23-27.

    22. [22]

      NEMATI M,FARAJZADEH M A,AFSHAR MOGADDAM M R A.Development of a surfactant-assisted dispersive solid phase extraction using deep eutectic solvent to extract four tetracycline antibiotics residues in milk samples[J].Journal of Separation Science,2021,44(10):2121-2130.

    23. [23]

      CHISVERT A,CARDENAS S,LUCENA R.Dispersive micro-solid phase extraction[J].Trac-Trends in Analytical Chemistry,2019,112:226-233.

    24. [24]

      CAPRIOTTI A L,CAVALIERE C,LA BARBERA G,et al.Recent applications of magnetic solid-phase extraction for sample preparation[J].Chromatographia,2019,82(8):1251-1274.

    25. [25]

      吴科盛,许恒毅,郭亮,等.磁性固相萃取在检测分析中的应用研究进展[J].食品科学,2011,32(23):317-320.

    26. [26]

      WANG H,ZHAO X Y,XU J W,et al.Determination of quinolones in environmental water and fish by magnetic metal organic frameworks based magnetic solid-phase extraction followed by high-performance liquid chromatography-tandem mass spectrometry[J].Journal of Chromatography A,2021,1651:462286.

    27. [27]

      ZHAO L M,LUCAS D,LONG D,et al.Multi-class multi-residue analysis of veterinary drugs in meat using enhanced matrix removal lipid cleanup and liquid chromatography-tandem mass spectrometry[J].Journal of Chromatography A,2018,1549:14-24.

    28. [28]

      郭添荣,吴文林,万渝平,等.HLB净化/高分辨液质联用法快速筛查动物肝脏中45种兽药残留[J].中国食品学报,2022,22(7):287-299.

    29. [29]

      孙晓杰,高金芳,李兆新,等.通过式净化-液相色谱-串联质谱快速筛查水产品中15类107种兽药多残留的方法研究[J].食品安全质量检测学报,2020,11(22):8240-8246.

    30. [30]

      JUNG H N,PARK D H,YOO K H,et al.Simultaneous quantification of 12 veterinary drug residues in fishery products using liquid chromatography-tandem mass spectrometry[J].Food Chemistry,2021,348:129105.

    31. [31]

      DINH Q T,MUNOZ G,VO DUY S,et al.Analysis of sulfonamides,fluoroquinolones,tetracyclines, triphenylmethane dyes and other veterinary drug residues in cultured and wild seafood sold in Montreal, Canada[J].Journal of Food Composition and Analysis,2020,94:103630.

    32. [32]

      PARK H,CHOI S Y,KANG H S,et al.Multi residue determination of 96 veterinary drug residues in domestic livestock and fishery products in South Korea[J].Aquaculture,2022,553:738064.

    33. [33]

      CASEY C R,ANDERSEN W C,WILLIAMS N T,et al.Multiclass, multiresidue method for the quantification and confirmation of 112 veterinary drugs in game meat (bison,deer,elk,and rabbit) by rapid polarity switching liquid chromatography-tandem mass spectrometry[J].Journal of Agricultural and Food Chemistry,2021,69(4):1175-1186.

    34. [34]

      张飞,王远,马小宁,等.超高效液相色谱-串联质谱法检测卤肉中36种兽药残留[J].食品工业科技,2023,44(13):340-348.

    35. [35]

      LEHOTAY S J,LIGHTFIELD A R.Extract-and-inject analysis of veterinary drug residues in catfish and ready-to-eat meats by ultrahigh-performance liquid chromatography tandem mass spectrometry[J].Journal of Aoac International,2020,103(2):584-606.

    36. [36]

      XU X,XU X Y,HAN M,et al.Development of a modified QuEChERS method based on magnetic multiwalled carbon nanotubes for the simultaneous determination of veterinary drugs, pesticides and mycotoxins in eggs by UPLC-MS/MS[J].Food Chemistry,2019,276:419-426.

    37. [37]

      XU X,ZHAO W H,JI B C,et al.Application of silanized melamine sponges in matrix purification for rapid multi-residue analysis of veterinary drugs in eggs by UPLC-MS/MS[J].Food Chemistry,2022,369:130894.

    38. [38]

      WANG C F,LI X W,YU F G,et al.Multi-class analysis of veterinary drugs in eggs using dispersive-solid phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry[J].Food Chemistry,2021,334:127598.

    39. [39]

      张珊,李述刚,黄小波,等.基于QuEChERS方法的鸭蛋兽药残留快速检测方法的构建[J].食品工业,2020,41(7):255-258.

    40. [40]

      张培杨.禽肉和禽蛋中左旋咪唑、甲苯咪唑及其两种代谢物残留HPLC-MS/MS检测方法的研究[D].扬州:扬州大学,2021.

    41. [41]

      PETRARCA M H,BRAGA P A D,REYES F G R,et al.Exploring miniaturized sample preparation approaches combined with LC-QToF-MS for the analysis of sulfonamide antibiotic residues in meat-and/or egg-based baby foods[J].Food Chemistry,2022,366:130587.

    42. [42]

      JI B C,ZHAO W H,XU X,et al.Development of a modified quick, easy,cheap, effective, rugged, and safe method based on melamine sponge for multi-residue analysis of veterinary drugs in milks by ultra-performance liquid chromatography tandem mass spectrometry[J].Journal of Chromatography A,2021,1651:462333.

    43. [43]

      JADHAV M R,PUDALE A,RAUT P,et al.A unified approach for high-throughput quantitative analysis of the residues of multi-class veterinary drugs and pesticides in bovine milk using LC-MS/MS and GC-MS/MS[J].Food Chemistry,2019,272:292-305.

    44. [44]

      LI J,REN X L,DIAO Y Y,et al.Multiclass analysis of 25 veterinary drugs in milk by ultra-high performance liquid chromatography-tandem mass spectrometry[J].Food Chemistry,2018,257: 259-264.

    45. [45]

      高鹏飞,龚威,汤亚云,等.牛、羊肉和牛、羊奶中兽药残留现状分析及检测技术研究进展[J].中国兽药杂志,2022,56(1):77-85.

    46. [46]

      YE S B,HUANG Y,LIN D Y.QuEChERS sample pre-processing with UPLC-MS/MS:A method for detecting 19 quinolone-based veterinary drugs in goat's milk[J].Food Chemistry,2022,373:131466.

    47. [47]

      黑真真,李莉,李硕,等.超高效液相色谱-单四极杆质谱联用法检测奶粉与酸奶中33种兽药残留[J].食品安全质量检测学报,2019,10(10):3054-3064.

    48. [48]

      曹亚飞,康健,常巧英,等.QuEChERS结合液相色谱-串联质谱法快速测定奶酪中多类兽药残留[J].色谱,2015,33(2):132-139.

    49. [49]

      陈瑞.可食用动物血制品中兽药多残留同时检测方法研究[D].秦皇岛:河北科技师范学院,2020.

    50. [50]

      张帅.蜂蜜、阿胶中化学性危害物检测技术研究[D].北京:国际关系学院,2020.

    51. [51]

      励炯,林伟杰,王红青,等.HPLC-MS/MS测定动物源性中药中的3种β2-受体激动剂残留[J].中国现代应用药学,2018,35(4):501-505.

    52. [52]

      JIN Y,ZHANG J Z,ZHAO W,et al.Development and validation of a multiclass method for the quantification of veterinary drug residues in honey and royal jelly by liquid chromatography-tandem mass spectrometry[J].Food Chemistry,2017,221:1298-1307.

    53. [53]

      LEI H Y,GUO J B,LYU Z,et al.Simultaneous determination of nitroimidazoles and quinolones in honey by modified QuEChERS and LC-MS/MS analysis[J].International Journal of Analytical Chemistry,2018,2018:4271385.

    54. [54]

      ZHANG Y,LI X Q,LI H M,et al.Antibiotic residues in honey:A review on analytical methods by liquid chromatography tandem mass spectrometry[J].Trac-Trends in Analytical Chemistry,2019,110:344-356.

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季宝成, 杨澜瑞, 韩雨, 等. 动物源性食品兽药多残留检测中基质净化与液相色谱-质谱联用技术研究进展[J]. 轻工学报, 2023, 38(5): 8-16. doi: 10.12187/2023.05.002
引用本文: 季宝成, 杨澜瑞, 韩雨, 等. 动物源性食品兽药多残留检测中基质净化与液相色谱-质谱联用技术研究进展[J]. 轻工学报, 2023, 38(5): 8-16. doi: 10.12187/2023.05.002
shu
JI Baocheng, YANG Lanrui, HAN Yu, et al. Research progress on matrix purification combined with LC-MS method for the detection of veterinary drug residues in animal-derived foods[J]. Journal of Light Industry, 2023, 38(5): 8-16. doi: 10.12187/2023.05.002
Citation: JI Baocheng, YANG Lanrui, HAN Yu, et al. Research progress on matrix purification combined with LC-MS method for the detection of veterinary drug residues in animal-derived foods[J]. Journal of Light Industry, 2023, 38(5): 8-16. doi: 10.12187/2023.05.002
shu

动物源性食品兽药多残留检测中基质净化与液相色谱-质谱联用技术研究进展

    作者简介:季宝成(1990-),男,河南省信阳市人,郑州轻工业大学讲师,博士,主要研究方向为食品质量与安全检测。E-mail:jibaocheng@zzuli.edu.cn
  • 1. 郑州轻工业大学 食品与生物工程学院, 河南 郑州 450001;
  • 2. 河南省冷链食品安全质量安全控制重点实验室, 河南 郑州 450001;
  • 3. 食品生产与安全河南省协同创新中心, 河南 郑州 450001
  • 收稿日期: 2022-08-29
  • 录用日期: 2022-10-26
基金项目:  国家自然科学基金青年基金项目(31901767,32202174)河南省重大公益专项项目(201300110100)郑州轻工业大学博士科研基金资助项目(13501050067,13501050079)

摘要: 对液相色谱-质谱(Liquid Chromatography-Mass Spectrometry,LC-MS)联用技术结合不同动物源基质净化技术在兽药多残留检测的研究进展及其应用状况进行了综述,指出,液-液萃取、分散液-液微萃取、固相萃取、固相微萃取、分散固相萃取、磁性固相萃取技术在肉类、蛋类、奶类及其制品等不同动物源性食品中的应用较广泛,但仍存在一定程度的局限性,如液-液萃取基质选择性弱、分散液-液微萃取适用对象有限、固相萃取耗时较长、固相微萃取重现性差、分散固相萃取净化效率适中等。未来可就构建多种类兽药残留同步净化方法、开发食品源基质特异性高效净化材料及增强基质净化过程快捷、自动化程度等方面进行深入研究,以期进一步推动LC-MS联用技术在动物源性食品兽药多残留检测中的应用。

English Abstract

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