泛醇-肉碱超分子低共熔物的制备及护肤性能研究

王扇珍; 宣晓蕊; 余述燕; 任钰婷; 郭大业; 樊凯奇

泛醇-肉碱超分子低共熔物的制备及护肤性能研究

王扇珍 ¹ ,
宣晓蕊 ¹ ,
余述燕 ^{2

,

,} ,
任钰婷 ² ,
郭大业 ² ,
樊凯奇 ²

1. 杭州沫润化妆品有限公司, 浙江杭州 311215;
2. 郑州轻工业大学材料与化学工程学院, 河南郑州 450001

作者简介: 王扇珍(1985—),男,山西潞城市人,杭州沫润化妆品有限公司工程师,主要研究方向为功能性护肤品的开发与护肤机制研究。Email:wangsz@hangcos.com.cn;

通讯作者: 余述燕,2014023@zzuli.edu.cn

基金项目: 河南省科技攻关项目(252102310461)
河南省校企协同创新项目(26AXQXT113)
中图分类号: TS974.1;TQ658.2

Preparation and skin care performance of panthenol-carnitine supramolecular deep eutectic mixture

1. Hangzhou Morun Cosmetics Co., Ltd, Hangzhou 311215, China;
2. College of Materials and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China

Corresponding author: Yu Shuyan, 2014023@zzuli.edu.cn

Received Date: 2025-12-31
Accepted Date: 2026-03-16
Available Online: 2026-04-21
CLC number: TS974.1;TQ658.2

摘要: 【目的】针对传统泛醇制剂黏腻感强、肤感不佳的问题，采用超分子技术对其改性并探究改性后护肤效果，以提升应用性能与使用体验。【方法】以左旋肉碱为氢键受体，与D-泛醇构建超分子低共熔物，借助傅里叶红外光谱仪、核磁共振氢谱仪和差示量热仪表征其结构，通过理论计算揭示分子间相互作用机制，利用流变学测试评价剪切应力及黏度变化，进一步结合转录组学分析与配方应用研究，明确护肤性能。【结果】成功制备泛醇-肉碱低共熔物，其超分子结构由多重氢键与静电作用协同维持；体系黏度显著降低且剪切稀化行为明显，有效改善了黏腻肤感；该低共熔物可上调胶原蛋白合成、细胞能量代谢相关基因，同时抑制炎症因子表达。【结论】超分子技术可显著改善传统泛醇制剂肤感，所得超分子泛醇-肉碱低共熔物具备明确的抗皱与抗炎活性。
- D-泛醇 /
- 左旋肉碱 /
- 超分子 /
- 护肤性能
Abstract: [Objective] Aiming at the problems of strong greasiness and poor skin feel of traditional panthenol preparations, supramolecular technology was adopted to modify panthenol, and the skin care efficacy of the modified product was investigated, so as to improve its application performance and user experience. [Methods] L-carnitine was used as the hydrogen bond acceptor to construct a supramolecular deep eutectic solvent (DES) with D-panthenol. The structure of the DES was characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy and differential scanning calorimetry. Theoretical calculations were performed to reveal the intermolecular interaction mechanism, and rheological tests were carried out to evaluate the changes in shear stress and viscosity. Furthermore, transcriptomic analysis combined with formulation application research was conducted to clarify the skin care properties. [Results] The panthenol-carnitine deep eutectic solvent was successfully prepared, and its supramolecular structure was synergistically stabilized by multiple hydrogen bonds and electrostatic interactions. The viscosity of the system was significantly reduced with an obvious shear-thinning behavior, which effectively improved the greasy skin feel. Transcriptomic analysis showed that the deep eutectic solvent could up-regulate the expression of genes related to collagen synthesis and cellular energy metabolism, while inhibiting the expression of inflammatory factors. [Conclusion] Supramolecular technology significantly optimizes the skin feel of traditional panthenol preparations, and the modified panthenol exhibits definite anti-wrinkle and anti-inflammatory activities.
- D-panthenol /
- L-carnitine /
- supramolecule /
- skin care performance
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沈阳化工大学材料科学与工程学院沈阳 110142

泛醇-肉碱超分子低共熔物的制备及护肤性能研究

作者简介: 王扇珍(1985—),男,山西潞城市人,杭州沫润化妆品有限公司工程师,主要研究方向为功能性护肤品的开发与护肤机制研究。Email:wangsz@hangcos.com.cn;

通讯作者: 余述燕,2014023@zzuli.edu.cn

Preparation and skin care performance of panthenol-carnitine supramolecular deep eutectic mixture

Corresponding author: Yu Shuyan, 2014023@zzuli.edu.cn

计量

通讯作者: 陈斌, bchen63@163.com

泛醇-肉碱超分子低共熔物的制备及护肤性能研究

作者简介:王扇珍(1985—),男,山西潞城市人,杭州沫润化妆品有限公司工程师,主要研究方向为功能性护肤品的开发与护肤机制研究。Email:wangsz@hangcos.com.cn

通讯作者: 余述燕, 2014023@zzuli.edu.cn

English Abstract

Preparation and skin care performance of panthenol-carnitine supramolecular deep eutectic mixture

Corresponding author: Yu Shuyan, 2014023@zzuli.edu.cn

目录

泛醇-肉碱超分子低共熔物的制备及护肤性能研究

作者简介: 王扇珍(1985—),男,山西潞城市人,杭州沫润化妆品有限公司工程师,主要研究方向为功能性护肤品的开发与护肤机制研究。Email:wangsz@hangcos.com.cn;

通讯作者: 余述燕,2014023@zzuli.edu.cn

Preparation and skin care performance of panthenol-carnitine supramolecular deep eutectic mixture

Corresponding author: Yu Shuyan, 2014023@zzuli.edu.cn

计量

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通讯作者: 陈斌, bchen63@163.com

泛醇-肉碱超分子低共熔物的制备及护肤性能研究

作者简介:王扇珍(1985—),男,山西潞城市人,杭州沫润化妆品有限公司工程师,主要研究方向为功能性护肤品的开发与护肤机制研究。Email:wangsz@hangcos.com.cn

通讯作者: 余述燕, 2014023@zzuli.edu.cn

English Abstract

Preparation and skin care performance of panthenol-carnitine supramolecular deep eutectic mixture

Corresponding author: Yu Shuyan, 2014023@zzuli.edu.cn

目录