JOURNAL OF LIGHT INDUSTRY

CN 41-1437/TS  ISSN 2096-1553

Article Contents
WANG Shanzhen, XUAN Xiaorui, Yu Shuyan, et al. Preparation and skin care performance of panthenol-carnitine supramolecular deep eutectic mixture[J]. Journal of Light Industry.
Citation: WANG Shanzhen, XUAN Xiaorui, Yu Shuyan, et al. Preparation and skin care performance of panthenol-carnitine supramolecular deep eutectic mixture[J]. Journal of Light Industry. shu

Preparation and skin care performance of panthenol-carnitine supramolecular deep eutectic mixture

  • Corresponding author: Yu Shuyan, 2014023@zzuli.edu.cn
  • Received Date: 2025-12-31
    Accepted Date: 2026-03-16
    Available Online: 2026-04-21
  • [Objective] Aiming at the problems of strong greasiness and poor skin feel of traditional panthenol preparations, supramolecular technology was adopted to modify panthenol, and the skin care efficacy of the modified product was investigated, so as to improve its application performance and user experience. [Methods] L-carnitine was used as the hydrogen bond acceptor to construct a supramolecular deep eutectic solvent (DES) with D-panthenol. The structure of the DES was characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy and differential scanning calorimetry. Theoretical calculations were performed to reveal the intermolecular interaction mechanism, and rheological tests were carried out to evaluate the changes in shear stress and viscosity. Furthermore, transcriptomic analysis combined with formulation application research was conducted to clarify the skin care properties. [Results] The panthenol-carnitine deep eutectic solvent was successfully prepared, and its supramolecular structure was synergistically stabilized by multiple hydrogen bonds and electrostatic interactions. The viscosity of the system was significantly reduced with an obvious shear-thinning behavior, which effectively improved the greasy skin feel. Transcriptomic analysis showed that the deep eutectic solvent could up-regulate the expression of genes related to collagen synthesis and cellular energy metabolism, while inhibiting the expression of inflammatory factors. [Conclusion] Supramolecular technology significantly optimizes the skin feel of traditional panthenol preparations, and the modified panthenol exhibits definite anti-wrinkle and anti-inflammatory activities.
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