明胶基复合水凝胶研究进展

刘瑞雪; 周腾; 樊晓敏; 李云秋; 冯皓泽

doi:10.3969/j.issn.2096-1553.2018.06.006

明胶基复合水凝胶研究进展

郑州轻工业学院材料与化学工程学院, 河南郑州 450001

作者简介: 刘瑞雪(1971-),女,河南省范县人,郑州轻工业学院副教授,博士,主要研究方向为高分子水凝胶、功能高分子材料.;

基金项目: 国家自然科学基金项目（21474092）；河南省留学归国人员择优资助项目；郑州轻工业学院博士基金项目
中图分类号: TQ431.3

Research progress in gelatin-based composite hydrogel

College of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China
Received Date: 2017-08-23
Accepted Date: 2018-01-12

CLC number: TQ431.3

摘要: 从明胶的交联改性、与其他高分子共混（包括互穿网络及双网络）和与纳米材料复合三方面对国内外关于明胶基复合水凝胶的力学性能增强与功能化的研究现状进行了综述，指出，相较于物理交联改性，明胶的化学交联改性应用更为广泛，但过多的化学交联剂用量会产生一定的毒性；互穿网络能够结合明胶与其他聚合物网络的性质，而双网络的拓扑结构能够极大地提升明胶基复合水凝胶的力学性能；将不同纳米粒子或具有特殊功能的纳米粒子引入明胶体系中能避免传统化学交联剂产生的毒性，获得具有高拉伸强度的功能化明胶基纳米复合水凝胶.进一步优化设计合成具有与生物组织相适宜的力学强度、生物相容性和组织粘附性的明胶基水凝胶材料，以提高其在复杂环境中的机械性能和刺激响应性能，将会是未来的研究方向.
- 明胶基复合水凝胶 /
- 交联改性 /
- 互穿网络 /
- 双网络 /
- 纳米复合
Abstract: The research status of the improvement of the mechanical properties and the functionalization of gelatin-based hydrogels from the cross-linking modification of gelatin, blending with other polymers (including interpenetrating network and dual network), and recombination with nanomaterials was reviewed. It was pointed out that the chemical cross-linking modification of gelatin was more widely used than physical cross-linking modification, but the excessive amount of chemical cross-linking agent would produce certain toxicity; the interpenetrating network could combine gelatin with other polymer networks. The nature of the dual network topology could greatly improve the mechanical properties of gelatin-based composite hydrogels; the introduction of different nanoparticles or nanoparticles with special functions into the gelatin system could avoid the toxicity of traditional chemical crosslinkers. Functionalized gelatin based nanocomposite hydrogel with high tensile strength was obtained. Further optimization and design of gelatin-based hydrogel materials with mechanical strength, biocompatibility and tissue adhesion suitable for biological tissues to improve their mechanical properties and stimuli in complex environments will be the future research direction.
- gelation-based composite hydrogel /
- cross-linking modification /
- interpenetrating network /
- double network /
- nanocomposite
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沈阳化工大学材料科学与工程学院沈阳 110142

明胶基复合水凝胶研究进展

作者简介: 刘瑞雪(1971-),女,河南省范县人,郑州轻工业学院副教授,博士,主要研究方向为高分子水凝胶、功能高分子材料.;

Research progress in gelatin-based composite hydrogel

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通讯作者: 陈斌, bchen63@163.com

明胶基复合水凝胶研究进展

作者简介:刘瑞雪(1971-),女,河南省范县人,郑州轻工业学院副教授,博士,主要研究方向为高分子水凝胶、功能高分子材料.

English Abstract

Research progress in gelatin-based composite hydrogel

目录

明胶基复合水凝胶研究进展

作者简介: 刘瑞雪(1971-),女,河南省范县人,郑州轻工业学院副教授,博士,主要研究方向为高分子水凝胶、功能高分子材料.;

Research progress in gelatin-based composite hydrogel

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通讯作者: 陈斌, bchen63@163.com

明胶基复合水凝胶研究进展

作者简介:刘瑞雪(1971-),女,河南省范县人,郑州轻工业学院副教授,博士,主要研究方向为高分子水凝胶、功能高分子材料.

English Abstract

Research progress in gelatin-based composite hydrogel

目录