壳聚糖-柠檬酸/聚丙烯酰胺双网络水凝胶的构筑与性能研究
Study on preparation and properties of chitosan-citrate/polyacrylamide double-network hydrogel
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摘要: 以壳聚糖（CS）、柠檬酸（CA）、丙烯酰胺（AAm）为原料，采用两步法制备壳聚糖-柠檬酸/聚丙酰胺（CS-CA/PAAm）双网络水凝胶，并对不同PAAm含量下其流变性能、力学性能、微观形貌等进行分析与表征.结果表明：当PAAm含量为34.6%时，该凝胶的储能模量最大，为50 kPa，由脆性凝胶变为断裂伸长率高达110%、压缩形变能力为90%的柔韧性凝胶，且在应变为60%的条件下循环压缩3次而几乎没有滞后圈，表现出良好的流变性能和力学性能.该水凝胶具有更加致密多孔的微观结构，随着PAAm的引入（0~34.6%），水凝胶的溶胀率从644%降低到84%，溶胀平衡时间由54 h缩短至25 h，且溶血率均小于5%，符合国标要求，安全性良好.Abstract: Using chitosan (CS), citrate (CA), and acrylamide (AAm) as raw materials, a two-step method was used to prepare the chitosan-citrate/polyacrylamide (CS-CA/PAAm) double-network hydrogel, and the rheological properties, mechanical properties and micro-morphology of the hydrogel with different PAAm contents were analyzed and characterized. The results showed that when the PAAm content was 34.6%, the storage modulus of the hydrogel was up to 50 kPa, and the brittle hydrogel became a flexible hydrogel with an elongation at break of up to 110% and a compressive deformation capacity of 90%. And under the condition of 60% strain, there were almost no hysteresis loops after cyclic compression 3 times, showing good rheological and mechanical properties. The hydrogel had a more dense and porous microstructure. With the introduction of PAAm (0~34.6%), the swelling rate of the hydrogel was reduced from 644% to 84%, and the swelling equilibrium time was shortened from 54 h to 25 h. The hemolysis rate was less than 5%, which met the national standard requirements and had good safety.
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Key words:
- chitosan /
- double-network hydrogel /
- rheological property /
- mechanical property /
- anti-hemolytic
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