沙棘酚类化合物化学组成及其生物活性研究进展
Research progress on chemical composition and bioactivity of Hippophae rhamnoides L.phenolic compounds
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摘要: 沙棘为药食同源植物,其功能活性主要源于富含沙棘酚类化合物(Hippophae rhamnoides L.Phenolic Compounds,HRPC)。基于HRPC的结构特征,梳理了164种HRPC的化学组成及其在不同品系、不同植株部位的分布规律,并阐述了其8种主要生物活性作用机制。HRPC以黄酮类、酚酸类和单宁类化合物为主,其中黄酮类化合物数量多达117种,具有抗氧化、抗炎、抗肿瘤、抗动脉粥样硬化、护胃、抗肺纤维化、抑制肥胖、调节肠道微生物群等多重生物活性。基于HRPC种类与含量、分布情况、生物活性机制和生物利用度现状,未来研究可聚焦在生物活性机制深度挖掘、加工方法革新、包裹体系优化等方面,以实现HRPC的高值化开发与沙棘产业升级。Abstract: Hippophae rhamnoides L. is a medicine-and-food homologous plant, and its functional activities mainly stem from its abundant phenolic compounds (HRPC). Based on the structural characteristics of HRPC, this review summarizes the chemical composition of 164 types of HRPCs and their distribution in different strains and plant parts, while highlighting the elucidation of their eight major bioactivity mechanisms. HRPCs are dominated by flavonoids, phenolic acids, and tannins. Among these, flavonoids constitute the main component with 117 identified types, which possess multiple bioactivities such as antioxidation, anti-inflammation, anti-tumorigenesis, anti-atherosclerosis, gastroprotection, anti-pulmonary fibrosis, anti-obesity, and gut microbiota modulation. Given the current status of HRPC species, content, distribution, bioactivity mechanisms, and bioavailability, future studies are recommended to focus on the in-depth exploration of bioactivity mechanisms, innovation of processing method , and optimization of encapsulation systems, thereby realizing the high-value utilization of HRPCs and the upgrading of the Hippophae rhamnoides L. industry.
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Key words:
- Hippophae rhamnoides L. /
- phenolic compounds /
- chemical composition /
- bioactivity
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