生物标志物检测方法的研究进展

武丰龙; 崔艳英; 张志锋; 王丹丹

doi:10.12187/2022.05.006

October 2022

Article Contents

WU Fenglong, CUI Yanying, ZHANG Zhifeng and et al. Research progress of methods for biomarker detection[J]. Journal of Light Industry, 2022, 37(5): 50-60. doi: 10.12187/2022.05.006

Citation: WU Fenglong, CUI Yanying, ZHANG Zhifeng and et al. Research progress of methods for biomarker detection[J]. Journal of Light Industry, 2022, 37(5): 50-60. doi: 10.12187/2022.05.006 shu

Research progress of methods for biomarker detection

1. College of Software Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China;
2. College of Computer and Communication Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China

Received Date: 2021-06-11
Accepted Date: 2022-01-20

Abstract

The application research progress of biomarker detection methods based on genetic material (RNA and DNA), immunology (antigen/antibody) and combined with microchip technology was reviewed. It was pointed out that the detection method based on genetic material acted directly on the target substance, and had high accuracy and good sensitivity, but it had many detection steps and high requirements for the detection environment; The detection method based on immunology was simple to operate, had high portabihity, and could realize instant detection. However, the accuracy was slightly lower. It was suitable for rapid and large-scale virus screening; Combining with microchip technology made the detection method more diverse. It could realize the detection of target substances in a short time, and the accuracy and degree of automation have been improved. This method showed great development potential in virus screening and disease diagnosis. In the future, the detection technology of biomarkers could be further studied in terms of optimizing the catalyst of the reaction, increasing the degree of purification of nucleic acid extracts, improving the automation of detection equipment, building multiple detection systems, realizing the miniaturization of detection equipment and visualization of detection information, etc. to improve detection accuracy and equipment portability so as to realize the continuous development of this technology.
- biomarker,
- detection method,
- genetic material,
- immunology,
- microchip technique
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Research progress of methods for biomarker detection

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