食源性活性肽调控巨噬细胞极化的研究进展

杨文建; 许征莉; 姚丽; 张传伟; 刘春利; 谢旻皓; 马宁; 苏安祥

doi:10.12187/2022.06.001

食源性活性肽调控巨噬细胞极化的研究进展

1. 南京财经大学食品科学与工程学院/江苏省现代粮食流通与安全协同创新中心/江苏高校粮油质量安全控制及深加工重点实验室, 江苏南京 210023;
2. 江苏卫生健康职业学院, 江苏南京 211800;
3. 安丘农业技术推广中心, 山东安丘 262100

作者简介: 杨文建(1982—),男,山东省菏泽市人,南京财经大学教授,博士,主要研究方向为食品营养。E-mail:lingwentt@163.com;

基金项目: “十三五”国家重点研发计划重点专项项目(2019YFC1606400)
江苏高校优势学科建设工程资助项目(PAPD)
江苏卫生健康职业学院校级科研项目(JKB202010)
中图分类号: TS201.4

Research progress in regulation of macrophage polarization by food-derived active peptides

1. College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing 210023, China;
2. Jiangsu Health Vocational College, Nanjing 211800, China;
3. Anqiu Agricultural Technology Extension Center, Anqiu 262100, China
Received Date: 2022-05-09

CLC number: TS201.4

摘要: 在简述食源性活性肽特点、巨噬细胞免疫调节原理的基础上,着重对食源性活性肽来源与制备、巨噬细胞极化现象及食源性活性肽调控巨噬细胞极化以发挥免疫调节作用的机制进行了综述,指出,食源性活性肽来源主要包括动物源、植物源、微生物源等,其制备方法主要有酶解法、物理辅助酶解法、微生物发酵法、微生物-酶协同法等,其中微生物-酶协同法有助于提高蛋白质水解度、转化率及提取肽的品质,是较好的食源性活性肽制备方法;食源性活性肽调控巨噬细胞极化发挥免疫调节作用的信号通路包括NF-κB、MAPK、TLR4/MyD88等。然而,巨噬细胞与机体健康的关系极为复杂,今后应重点采用代谢组学、基因敲除等技术从巨噬细胞功能多样性、信号通路的协同作用等方面研究食源性活性肽调控巨噬细胞极化对机体健康的作用,以期为食源性活性肽在功能性食品中的应用提供理论依据。
- 食源性活性肽 /
- 巨噬细胞 /
- 极化 /
- 免疫调节
Abstract: Based on the brief introduction of the characteristics food-derived active peptides and immunomodulation principle of macrophage, the source and preparation of food-derived active peptides, the phenomenon of macrophage polarization, and the mechanism of food-derived active peptides regulating macrophage polarization to exert immunomodulatory effects were highlighted in the review. It pointed out that food-derived active peptides mainly included animal sources, plant sources, microbial sources and other active peptides, and their preparation methods mainly included enzymatic hydrolysis, physical assisted enzymatic hydrolysis, microbial fermentation, microbial-enzyme synergy. The microbial-enzyme synergy method had the advantages of improving the degree of hydrolysis, conversion rate of protein and the quality of extracted peptide, which was a good method to prepare food-derived active peptides. Food-derived active peptides could regulate macrophage polarization to play an immunomodulatory role. The signal pathways including NF-κB, MAPK, and TLR4/MyD88, which were important for regulating the polarization of macrophages. However, due to the complex relationship between macrophages and health, in the future, metabolomics, gene knockout and other new technologies should be used to study the effect of food-derived active peptides on regulating macrophage polarization and health from the aspects of macrophage functional diversity and synergistic effect of signaling pathways. It was expected that this review was able to provide theoretical basis for the application of food-derived active peptides in functional food.
- food-derived active peptides /
- macrophage /
- polarization /
- immunomodulation
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沈阳化工大学材料科学与工程学院沈阳 110142

食源性活性肽调控巨噬细胞极化的研究进展

作者简介: 杨文建(1982—),男,山东省菏泽市人,南京财经大学教授,博士,主要研究方向为食品营养。E-mail:lingwentt@163.com;

Research progress in regulation of macrophage polarization by food-derived active peptides

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通讯作者: 陈斌, bchen63@163.com

食源性活性肽调控巨噬细胞极化的研究进展

作者简介:杨文建(1982—),男,山东省菏泽市人,南京财经大学教授,博士,主要研究方向为食品营养。E-mail:lingwentt@163.com

English Abstract

Research progress in regulation of macrophage polarization by food-derived active peptides

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食源性活性肽调控巨噬细胞极化的研究进展

作者简介: 杨文建(1982—),男,山东省菏泽市人,南京财经大学教授,博士,主要研究方向为食品营养。E-mail:lingwentt@163.com;

Research progress in regulation of macrophage polarization by food-derived active peptides

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通讯作者: 陈斌, bchen63@163.com

食源性活性肽调控巨噬细胞极化的研究进展

作者简介:杨文建(1982—),男,山东省菏泽市人,南京财经大学教授,博士,主要研究方向为食品营养。E-mail:lingwentt@163.com

English Abstract

Research progress in regulation of macrophage polarization by food-derived active peptides

目录