泛醇-肉碱超分子低共熔物的制备及其护肤性能研究

王扇珍; 宣晓蕊; 余述燕; 任钰婷; 郭大业; 樊凯奇

doi:10.12187/2026.04.012

August 2026

Article Contents

WANG Shanzhen, XUAN Xiaorui, YU Shuyan, et al. Preparation and skincare properties of panthenol-carnitine supramolecular deep eutectic mixture[J]. Journal of Light Industry, 2026, 41(4): 122-133. doi: 10.12187/2026.04.012

Citation: WANG Shanzhen, XUAN Xiaorui, YU Shuyan, et al. Preparation and skincare properties of panthenol-carnitine supramolecular deep eutectic mixture[J]. Journal of Light Industry, 2026, 41(4): 122-133. doi: 10.12187/2026.04.012 shu

Preparation and skincare properties of panthenol-carnitine supramolecular deep eutectic mixture

1. Hangzhou Morun Cosmetics Co., Ltd., Hangzhou 311215, China;
2. College of Materials and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China

Corresponding author: YU Shuyan, 2014023@zzuli.edu.cn
Received Date: 2025-12-31
Accepted Date: 2026-03-16

Abstract

【Objective】 This study aimed to alleviate the marked greasiness and poor skin feel of conventional panthenol formulations and to enhance their skincare efficacy and application performance.【Methods】 A supramolecular modification strategy was employed to modify panthenol. Using L-carnitine as the hydrogen bond acceptor, a supramolecular deep eutectic solvent (DES), designated as supramolecular panthenol, was constructed with D-panthenol. Its structure was characterized by Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (¹H NMR), and differential scanning calorimetry (DSC). Theoretical calculations were performed to elucidate the intermolecular interaction mechanism, and rheological tests were conducted to evaluate the shear stress and viscosity changes of the system. Transcriptomic analysis and formulation application studies were further carried out to clarify its skincare performance.【Results】 The supramolecular panthenol was successfully prepared, and its structure was synergistically maintained by multiple hydrogen bonds and electrostatic interactions. The system exhibited significantly reduced viscosity and pronounced shear-thinning behavior. The supramolecular panthenol upregulated the expression of genes involved in collagen synthesis and cellular energy metabolism while inhibiting the expression of inflammatory factors. When formulated into an essence product, it markedly reduced greasiness and delivered multiple skincare benefits, including moisturization, skin barrier repair, soothing and anti-inflammatory effects, anti-wrinkle efficacy, and skin firming.【Conclusion】 The supramolecular modification strategy can significantly improve the skin feel of conventional panthenol preparations, and the result ing supramolecular panthenol holds considerable promise for the development of functional skincare ingredients.
- D-panthenol,
- L-carnitine,
- supramolecular deep eutectic mixture,
- skincare property
References
1. [1]
  KULIKOV A U,ZINCHENKO A A.Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations[J].Journal of Pharmaceutical and Biomedical Analysis,2007,43(3):983-988.
2. [2]
  PROKSCH E,DE BONY R,TRAPP S,et al.Topical use of dexpanthenol:a 70th anniversary article[J].Journal of Dermatological Treatment,2017,28(8):766-773.
3. [3]
  EBNER F,HELLER A,RIPPKE F,et al.Topical use of dexpanthenol in skin disorders[J].American Journal of Clinical Dermatology,2002,3(6):427-433.
4. [4]
  WOLLENBERG A.Basic emollients for the management of xerosis cutis:biophysical properties,clinical evidence,and practical considerations[J].International Journal of Dermatology,2025,64(S1):3-4.
5. [5]
  钱进,邓慧,李华真,等.化妆品中保湿剂的拮抗与增效作用探究[J].广东化工,2022,49(19):49-54
  ,22. QIAN J,DENG H,LI H Z,et al.Research on antagonistic and synergistic effects of moisturizers in cosmetics[J].Guangdong Chemical Industry,2022,49(19):49-54,22.
6. [6]
  PETROVIĆ J D,CAREVIĆ MILIĆ EVIĆ T A,GLAMO AČG LIJA J M,et al.Mixture containing 5% polysaccharide extract of Cerioporus squamosus (huds.)quélet,5% dexpanthenol,and 0.2% hyaluronic acid shows in vitro and in vivo wound healing properties[J].Pharmaceuticals,2025,18(3):416.
7. [7]
  朱佳.含β-葡聚糖和泛醇的喷雾剂对小鼠AEW模型修复皮肤屏障、缓解炎症及瘙痒的作用[D].北京:北京协和医学院,2022. ZHU J.Effects of sprays containing β-glucan and panthenol onrepairing skin barrier,alleviating inflammation and pruritus in an AEW-induced mouse model [D].Beijing:Peking Union Medical College Hospital,2022.
8. [8]
  HUTH S,MARQUARDT Y,HUTH L,et al.Molecular insights into the effects of laser-induced optical breakdown (LIOB)after 1064 nm picosecond laser irradiation using a novel melanocyte-containing 3D skin model[J].Lasers in Medical Science,2025,40(1):223.
9. [9]
  TAN C,PENG K,LIM T,et al.The combination of allantoin,bisabolol,D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes[J].International Journal of Cosmetic Science,2024,46(5):691-701.
10. [10]
  PAVLA AČG KOVÁ J,EGNER P,SEDLÁ AČG EK T,et al.In vivo efficacy and properties of semisolid formulations containing panthenol[J].Journal of Cosmetic Dermatology,2019,18(1):346-354.
11. [11]
  蔡雅琴.“丹皮酚-薄荷脑”低共熔物纳米乳凝胶的制备与评价[D].银川:宁夏医科大学,2017. CAI Y Q.Preparation and evaluation of nanoemulsion-loaded gel based on paeonol-menthol eutectic mixture [D].Yin Chuan:Ningxia Medical University,2017.
12. [12]
  BAI D,WANG Z Y,XIAO Y,et al.Transdermal delivery of elastin peptide assisted by betaine-based deep eutectic solvent to ameliorate skin photoaging[J].Biomaterials Advances,2024,163:213965.
13. [13]
  CZYRSKI G S,FRESE HJORT M K,RADES T,et al.Comparing effects of terpene-based deep eutectic solvent and solid microneedles on skin permeation of drugs with varying lipophilicity[J].European Journal of Pharmaceu-tics and Biopharmaceutics,2024,205:114576.
14. [14]
  KAPRE S,PALAKURTHI S S,JAIN A,et al.DES-igning the future of drug delivery:a journey from fundamentals to drug delivery applications[J].Journal of Molecular Liquids,2024,400:124517.
15. [15]
  李明键,赵志远,郑璐遥,等.ILs/DES在经皮药物递送中的应用研究进展[J].中国医药工业杂志,2022,53(4):454-463.
  LI M J,ZHAO Z Y,ZHENG L Y,et al.Research progress in application of ILs/DES in transdermal drug delivery[J].Chinese Journal of Pharmaceuticals,2022,53(4):454-463.
16. [16]
  周湖武,唐莉凤,周紫燕,等.一种超分子酸酶组合物的开发及其去角质功效评价[J].香料香精化妆品,2025(5):72-77. ZHOU H W,TANG L F,ZHOU Z Y,et al.Development of a supramolecular acid-enzyme composition and evaluation of its exfoliation efficacy[J].Flavour Fragrance Cosmetics,2025
  (5):72-77.
17. [17]
  NAVA-OCAMPO M F,AL FUHAID L,SANTANA A,et al.Structural properties and stability of the Betaine-Urea natural deep eutectic solvent[J].Journal of Molecular Liquids,2021,343:117655.
18. [18]
  文静,牛俊淞,吴玉珍,等.冰片-薄荷脑低共熔物载川芎嗪纳米乳凝胶制备[J].中成药,2025,47(8):2522-2529.
  WEN J,NIU J S,WU Y Z,et al.Preparation of borneol-menthol eutectic mixture-loaded nanoemulsion gel of tetramethylpyrazine[J].Chinese Traditional Patent Medicine,2025,47(8):2522-2529.
19. [19]
  HUBER V,HIOE J,TOURAUD D,et al.Uncovering the curcumin solubilization ability of selected natural deep eutectic solvents based on quaternary ammonium compounds[J].Journal of Molecular Liquids,2022,361:119661.
20. [20]
  WANG D Y,ZHANG M,LAW C L,et al.Natural deep eutectic solvents for the extraction of lentinan from shiitake mushroom:COSMO-RS screening and ANN-GA optimizing conditions[J].Food Chemistry,2024,430:136990.
21. [21]
  PEIRANO R I,HAMANN T,DUSING H J,et al.Topically applied L-carnitine effectively reduces sebum secretion in human skin[J]. Journal of Cosmetic Dermatology,2012, 11: 30-36.
22. [22]
  HOU Y C,ZHANG B Z,GAO M J,et al.Densities,viscosities and specific heat capacities of deep eutectic solvents composed of ethanediol +betaine and ethanediol +L-carnitine for absorbing SO₂[J].The Journal of Chemical Thermodynamics,2023,179:106999.
23. [23]
  MEHRABI F,GHAEDI M,ALIPANAHPOUR DIL E.Dl-carnitine-based green hydrophobic deep eutectic solvent for the enrichment of bisphenol A in mineral water based on ultrasound-assisted liquid-phase microextraction[J].Talanta,2024,266:125045.
24. [24]
  叶玉玺,丁晓茜,池华睿,等.疏水性低共熔溶剂氢键交互作用调控及萃取铜性能[J].化工进展,2022,41(S1):397-406.
  YE Y X,DING X X,CHI H R,et al.Hydrophobic deep eutectic solvent hydrogen bond interaction regulation and extraction performance of copper[J].Chemical Industry and Engineering Progress,2022,41(S1):397-406.
25. [25]
  NASEEM Z,SHEHZAD R A,IHSAN A,et al.Theoretical investigation of supramolecular hydrogen-bonded choline chloride-based deep eutectic solvents using density functional theory[J].Chemical Physics Letters,2021,769:138427.
26. [26]
  崔凯,吴伟伟,刁其玉.转录组测序技术的研究和应用进展[J].生物技术通报,2019,35(7):1-9.
  CUI K,WU W W,DIAO Q Y.Application and research progress on transcriptomics[J].Biotechnology Bulletin,2019,35(7):1-9.
27. [27]
  CAMP B,STEGEMANN-KONISZEWSKI S,SCHREIBER J.Infection-associated mechanisms of neuro-inflammation and neuro-immune crosstalk in chronic respiratory diseases[J].International Journal of Molecular Sciences,2021,22:5699.
Proportional views

Get Citation

PDF

XML

Article Metrics

Article views(343) PDF downloads(1) Cited by()

Ralated

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Preparation and skincare properties of panthenol-carnitine supramolecular deep eutectic mixture

Abstract

References

Proportional views

Article Metrics

Ralated

Proportional views

通讯作者: 陈斌, bchen63@163.com