壳聚糖-魔芋葡甘聚糖基苯甲醇微胶囊制备及其缓释性能研究
Preparation and sustained release of chitosan-konjac glucomannan-based benzyl alcohol microcapsules
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摘要: 【目的】提高苯甲醇的稳定性和缓释性。【方法】以壳聚糖、魔芋葡甘聚糖作为复合壁材制备苯甲醇微胶囊,采用响应面法优化其制备工艺,并采用傅里叶变换红外光谱(FTIR)仪、扫描电子显微电镜(SEM)、场发射透射电镜(FETEM)等对其进行表征,通过一级动力学、Higuchi动力学和Peppas动力学模型研究其缓释性能。【结果】苯甲醇微胶囊的最佳制备工艺条件为魔芋葡甘聚糖用量0.10 g、吐温80用量0.25 mL、三聚磷酸钠用量0.50 g,在此条件下,该微胶囊的负载率为16.95%。FTIR显示该微胶囊图谱在1040 cm-1、2880 cm-1和874 cm-1分别出现苯甲醇、壳聚糖和魔芋葡甘聚糖的特征吸收峰,证明这3种组分均存在于该微胶囊体系中。SEM和ETEM显示该微胶囊呈颗粒凸起、球形。在常温(20 ℃)和高温(80 ℃)环境下,该微胶囊均可显著减缓苯甲醇的挥发损失,且其缓释过程符合一级动力学方程和Peppas动力学方程。【结论】苯甲醇微胶囊的热稳定性、缓释性能均较苯甲醇有显著提高。Abstract: 【Objective】This study aimed to improve the stability and sustained-release performance of benzyl alcohol.【Methods】Benzyl alcohol microcapsules were prepared using chitosan (CS) and konjac glucomannan (KGM) as composite wall materials. The preparation process was optimized by response surface methodology. The microcapsules were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy, and field-emission transmission electron microscopy (FETEM). The sustained-release performance was investigated using three kinetic models: first-order kinetics, Higuchi kinetics, and Peppas kinetics.【Results】Using KGM dosage, Tween 80 dosage, and sodium tripolyphosphate (STP) dosage as independent variables and the loading efficiency of benzyl alcohol microcapsules as the dependent variable, response surface methodology was applied to determine the optimal preparation conditions: KGM, 0.10 g; Tween 80, 0.25 mL; and STP, 0.50 g. Under these conditions, the loading efficiency of the benzyl alcohol microcapsules reached 16.95%. FTIR showed that the characteristic absorption peaks of benzyl alcohol, CS, and KGM appeared at 1040 cm-1, 2880 cm-1, and 874 cm-1, respectively, confirming that all three components were present in the microcapsule system. SEM and FETEM revealed that the microcapsules exhibited a spherical morphology with granular protrusions. At both room temperature (20 ℃) and high temperature (80 ℃), the microcapsules significantly reduced the volatilization loss of benzyl alcohol, and their sustained-release process followed first-order and Peppas kinetic equations.【Conclusion】The thermal stability and sustained-release performance of benzyl alcohol were significantly improved after microencapsulation.
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Key words:
- benzyl alcohol /
- microcapsules /
- konjac glucomannan /
- chitosan /
- response surface optimization /
- sustained release
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