JOURNAL OF LIGHT INDUSTRY

CN 41-1437/TS  ISSN 2096-1553

Volume 29 Issue 3
May 2014
Article Contents
ZHANG Gai-hong, WANG Nan, BAI Bing and et al. Review of the synthesis of glycosides from glycosyl halide[J]. Journal of Light Industry, 2014, 29(3): 25-29. doi: 10.3969/j.issn.2095-476X.2014.03.006
Citation: ZHANG Gai-hong, WANG Nan, BAI Bing and et al. Review of the synthesis of glycosides from glycosyl halide[J]. Journal of Light Industry, 2014, 29(3): 25-29. doi: 10.3969/j.issn.2095-476X.2014.03.006 shu

Review of the synthesis of glycosides from glycosyl halide

  • Received Date: 2014-02-17
  • The recent advances in organic synthesis of glucosides from glycosyl halide were summarized, including glycosyl bromide, glycosyl fluoride, glycosyl iodide as glycosyl donors. The advantage of these glycosyl halides as glycosyl donor is that the synthetic product is pure O-glycosides with high yield, mainly for the β-configuration. The disadvantage is the harsh reaction conditions,which are strictly anhydrous,light avoiding, expensive heavy metal salt catalyst and great toxicity. Glycosyl bromide was unstable at room temperature and not easy for long-term preservation. Thus, exploration of novel glycosyl halide derivatives, implementation of stereo-selectively synthesis, exploration of green synthesis conditions, and avoiding the use of heavy metal salts, are the future research direction in this field.
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