WANG Guoqing, CHU Minglin, LI Zhenxing, et al. Application of ESI-HRMS method in analysis of the synthesis process of catalpol propionylated products[J]. Journal of Light Industry, 2018, 33(3): 1-7. doi: 10.3969/j.issn.2096-1553.2018.03.001
Citation:
WANG Guoqing, CHU Minglin, LI Zhenxing, et al. Application of ESI-HRMS method in analysis of the synthesis process of catalpol propionylated products[J]. Journal of Light Industry, 2018, 33(3): 1-7.
doi:
10.3969/j.issn.2096-1553.2018.03.001
Application of ESI-HRMS method in analysis of the synthesis process of catalpol propionylated products
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College of Materials and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China;
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College of Pharmacy, He'nan University of Chinese Medicine, Zhengzhou 450046, China;
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He'nan Analysis and Testing Centre, Zhengzhou 450002, China
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Received Date:
2017-11-15
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Abstract
Using electrospray ionization-high resolution mass spectrometry (ESI-HRMS) method to confirm the catalpol propionylated products,and using peak area normalizing method to complete the semi quantitative,the analysis method on the synthesize process of catalpol propionylated products was established.The results showed that the ESI-HRMS method could quickly determine the type of propionylated products; the peak area normalization method could calculate the relative content of each catalpol propionylated products, which could be controlled to synthesize the main or mixed products with the specific structure by controlling the reaction conditions according to the need. The application of ESI-HRMS method in the reaction process of catalpol propanolation could provide a new approach for the analysis of the synthesis process of catalpol propanylated products.
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References
-
[1]
LIN C,LU Y,YAN X J,et al.Catalpol protects glucose-deprived rat embryonic cardiac cells by inducing mitophagy and modulating estrogen receptor[J].Biomedicine & Pharmacotherapy,2017,89:973.
-
[2]
董春红,王强,王国庆,等.一种丙酰化的梓醇衍生物及其制备方法和应用[P].中国:201710974075.3,2017-10-19.
-
[3]
段煜,杜宗良,李瑞霞,等.天然多羟基化合物在酶催化下的选择性酯化[J].天然产物研究与开发,2006,18(4):702.
-
[4]
SHETTAR A K,SATEESH M K,KALIWAL B B,et al.In vitro antidiabetic activities and GC-MS phytochemical analysis of Ximenia americana extracts[J].South African Journal of Botany,2017,111:202.
-
[5]
王国庆,彩倩杰,刘云,等.顶空-气相色谱-质谱法测定改性聚硫橡胶中挥发性成分[J].郑州轻工业学院学报(自然科学版),2015,30(2):1.
-
[6]
胡玉熙,刘清飞,从文娟,等.气质联用技术在生物医药领域中的应用进展[J].药物分析杂志,2008,28(6):999.
-
[7]
FENG Y K,LIU Z Z,PENG Y,et al.Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma:Application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction[J].Biomedical Chromatography,2013,27(11):1503.
-
[8]
孙雨安,柯玮,李振兴,等.DART-Orbitrap质谱法快速筛查饲料中磺胺类药物[J].质谱学报,2014,35(1):52.
-
[9]
汪亚丽,王鹭,曾苏,等.质谱法在药物立体异构体区分中的应用及发展[J].质谱学报,2017,38(4):400.
-
[10]
田桂花,范子琳,邓震宇,等.半定量和定量分析测定SBS颗粒抗氧化剂含量[J].消防科学与技术,2011,30(2):171.
-
[11]
李佳斌,郝斐然,田芳,等.质谱电喷雾电离源研究新进展[J].质谱学报,2013,34(2):65.
-
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