高<i>F</i>值寡肽的功能特性研究进展

秦于思; 程明; 韦海涛; 高兴明; 范小雪; 王存芳

doi:10.12187/2021.03.004

高F值寡肽的功能特性研究进展

1. 齐鲁工业大学(山东省科学院) 食品科学与工程学院, 山东济南 250300;
2. 青岛市畜牧兽医研究所, 山东青岛 266100;
3. 山东熊猫乳品有限公司, 山东济南 251400

作者简介: 秦于思(1996-),女,山东省日照市人,齐鲁工业大学硕士研究生,主要研究方向为乳品科学.;

基金项目: 山东省重点研发计划项目（2019YYSP025）；山东省自然科学基金项目（ZR2020MC210）；山东省农业重大应用技术创新项目（SD2019ZZ006）；国家级大学生创新创业训练计划项目（201910431002）
中图分类号: TS201.1

Research progress in functional characteristics of high Fisher ratio oligopeptides

1. College of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Ji'nan 250300, China;
2. Qingdao Research Institute of Husbandry and Veterinary, Qingdao 266100, China;
3. Shandong Panda Dairy Co., Ltd., Ji'nan 251400, China
Received Date: 2020-07-03

CLC number: TS201.1

摘要: 高F值寡肽因其独特的氨基酸组成而具有多种生理活性，通过对其功能特性及活性机理相关文献进行梳理，指出：高F值寡肽具有良好的抗疲劳和解醉酒功能特性，可作为生物活性肽应用于抗疲劳饮料、醒酒汤等功能性产品的开发；高F值寡肽在辅助治疗肝病、促进肝病患者体内F值回到正常范围等方面具有重要作用，但对肝病的影响机制尚不明确，需进一步的研究验证；高F值寡肽可调节体内苯丙氨酸代谢，开发高F值寡肽的医药食品将成为苯丙酮尿症（PKU）食疗的发展方向之一.未来可就高F值寡肽在医用食品中的消化特性和适用性、益生功能特性、加工过程中与其他食品组分的相互作用及对食品品质特性的影响等方面开展深入研究，以进一步拓展高F值寡肽在医用食品行业中的应用.
- 高F值寡肽 /
- 功能特性 /
- 活性机理
Abstract: High Fisher ratio oligopeptides had a variety of physiological activities due to their unique amino acid composition.This article reviewed the related literature on functional properties and active mechanism of high Fisher ratio oligopeptides due to the unique amino acid composition.It pointed out that high Fisher ratio oligopeptides have good anti-fatigue and alcohol relieving functions,and it could be used as biologically active peptides in the development and application of anti-fatigue beverages,alcohol relieving soups and other functional products;high Fisher ratio oligopeptides could assist in the treatment of liver disease and promote the return of the Fisher ratio of the normal range,but the mechanism of the effect on liver disease is still unclear and need further research and verification;high Fisher ratio oligopeptides could regulate the metabolism of phenylalanine in the body,high Fisher ratio oligopeptides medicine and food would become one of the development directions of phenylketonuria (PKU) diet therapy.In the future,in-depth research could be carried out on the digestive properties and applicability of high Fisher ratio oligopeptides in medical foods,probiotic functional properties,interaction with other food components during processing,and the impact on food quality characteristics,to further promote application of high Fisher ratio oligopeptides in medical food industry.
- high Fisher ratio oligopeptides /
- functional characteristics /
- activity mechanism
1. [1]
  LI T,TIAN Y,SUN F,et al.Preparation of high Fischer's ratio corn oligopeptides using directed enzymatic hydrolysis combined with adsorption of aromatic amino acids for efficient liver injury repair[J].Process Biochemistry,2019,84:60.
2. [2]
  TANIMOTO S,TANABE S,WATANABE M,et al.Enzymatic modification of zein to produce a non-bitter peptide fraction with a very high Fischer ratio for patients with hepatic encephalopathy(food & nutrition)[J].Agricultural and Biological Chemistry,1991,55(4):1119.
3. [3]
  ADACHI S,YAMANAKA T,HAYASHI S,et al.Preparation of peptide mixture with high Fischer ratio from protein hydrolysate by adsorption on activated carbon[J].Bioseparation,1992,3(4):227.
4. [4]
  PEDROCHE J,YUST M M,LQARI H,et al.Production and characterization of casein hydrolysates with a high amino acid Fischer's ratio using immobilized proteases[J].International Dairy Journal,2004,14(6):527.
5. [5]
  PEDROCHE J,YUST M D M,LQARI H,et al.Production of brassica carinata protein hydrolyzates with a high Fischer's ratio using immobilized proteases[J].Journal of Agricultural and Food Chemistry,2007,54(20):7621.
6. [6]
  陶静,丁冬各,陈荫,等.带鱼高F值寡肽的制备工艺及活性[J].水产学报,2018,42(10):1648.
7. [7]
  祁文翰.鱿鱼高F值寡肽制备优化及工厂设计[D].舟山:浙江海洋大学,2017.
8. [8]
  ZHENG H N,ZHANG C H,CAO W H,et al.Preparation and characterisation of the pearl oyster (Pinctada martensii) meat protein hydrolysates with a high Fischer ratio[J].International Journal of Food Science and Techno-logy,2009,44(6):1183.
9. [9]
  杨华青,侯威,赵磊,等.玉米黄粉二步酶解制备高F值寡肽的工艺优化[J].食品科学技术学报,2019,37(6):100.
10. [10]
  蒋竹青,李萍,张明振,等.玉米高F值寡肽的分离纯化及抗氧化活性研究[J].食品与药品,2014,16(6):397.
11. [11]
  金英姿,王大为.玉米高F值寡肽的制备研究[J].食品研究与开发,2014,35(11):80.
12. [12]
  杨秀芝,王艳,杨安树,等.双酶水解对豆芽蛋白潜在致敏性和理化性质的影响[J].南昌大学学报(理科版),2018,42(6):563.
13. [13]
  秦于思,程明,陈平华,等.基于乳源性蛋白制备高F值寡肽的研究进展[J].乳业科学与技术,2020,43(6):31.
14. [14]
  玄依凡,王荣春.乳清蛋白水解方法的比较研究[J].食品工业,2017,38(3):239.
15. [15]
  韦荣编,黄程,罗红宇,等.食物源蛋白高F值寡肽的制备及应用研究进展[J].食品科学,2014,35(15):289.
16. [16]
  LIN Y T,CHIU M S,CHANG C K.Branched-chain amino acids and arginine improve physical but not skill performance in two consecutive days of exercise[J].Science & Sports,2017,32(6).
17. [17]
  CHEN I F,WU H J,CHEN C Y,et al.Branched-chain amino acids,arginine,citrulline alleviate central fatigue after 3 simulated matches in taekwondo athletes:a randomized controlled trial[J].Journal of the International Society of Sports Nutrition,2016,13(1):28.
18. [18]
  TOMASZ M,JAN D,WOJCIECH H,et al.Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men[J].Folia Neuropathologica,2015,53(4):377.
19. [19]
  FERNSTROM J D.Branched-chain amino acids and brain function[J].The Journal of Nutrition,2005,135(6):1539S.
20. [20]
  NEWSHOLME E A,BLOMSTRAND E.Branched-chain amino acids and central fatigue[J].Journal of Nutrition,2006,136(1):274S.
21. [21]
  MEEUSEN R,WATSON P.Amino acids and the brain:do they play a role in "central fatigue"?[J].International Journal of Sport Nutrition and Exercise Metabolism,2007,17(S1):S37.
22. [22]
  CHEN Y M,LIN C L,WEI L,et al.Sake protein supplementation affects exercise performance and biochemical profiles in power-exercise-trained mice[J].Nutrients,2016,8(2):106.
23. [23]
  陈星星,胡晓,李来好,等.抗疲劳肽的研究进展[J].食品工业科技,2015,36(4):365.
24. [24]
  张铁华,殷涌光,刘静波,等.高F值寡肽抗疲劳作用的研究及其饮料的开发[J].食品科学,2007(5):308.
25. [25]
  李润国,庞文渌.酶解法制备花生粕高F值寡肽混合物及其缓解疲劳作用的研究[J].粮油食品科技,2015,23(1):43.
26. [26]
  丁运文,汤兴俊,陈心馨,等.解酒护肝饮解酒及对急慢酒精性肝损伤的保护作用[J].基因组学与应用生物学,2019,38(5):2276.
27. [27]
  丁运文.解酒护肝饮解酒及对急慢酒精性肝损伤保护作用的研究[D].上海:上海交通大学,2018.
28. [28]
  郑明洋.玉米高F值寡肽的制备及生理功能研究[D].济南:济南大学,2013.
29. [29]
  曾瑜,潘兴昌,张立实,等.小麦低聚肽对小鼠解酒功能的评价[J].现代预防医学,2019,46(7):1255.
30. [30]
  黄程,杜帅,宋茹,等.鲣鱼肉高F值寡肽液的生理活性研究[J].食品工业,2015,36(3):246.
31. [31]
  蒋竹青.玉米高F值寡肽的制备及生理功能研究[D].济南:济南大学,2015.
32. [32]
  TAJIRI K.Branched-chain amino acids in liver diseases[J].World Journal of Gastroenterology,2013,19(43):7620.
33. [33]
  AKITOSHI S,EIJI K,TATSUKI M,et al.The profiling of plasma free amino acids and the relationship between serum albumin and plasma-branched chain amino acids in chronic liver disease:a single-center retrospective study[J].Journal of Gastroenterology,2018,53(8):978.
34. [34]
  JUNGGIL P,WONYOUNG T,SOOYOUNG P,et al.Effects of branched-chain amino acid (BCAA) supplementation on the progression of advanced liver disease:a korean nationwide,multicenter,prospective,observational,cohort study[J].Nutrients,2020,12(5):1429.
35. [35]
  SUGIYAMA K,YU L,NAGASUE N.Direct effect of branched-chain amino acids on the growth and metabolism of cultured human hepatocellular carcinoma cells[J].Nutrition and Cancer,1998,31(1):62.
36. [36]
  KAWAGUCHI T,TORIMURA T.Branched chain amino acids:a factor for zone 3 steatosis in non-alcoholic fatty liver disease[J].Hepatology Research,2019,49(8):841.
37. [37]
  简清.支链氨基酸肠内营养制剂对肝功能损害患者的影响[J].蛇志,2015,27(3):258.
38. [38]
  KAKAZU E,SANO A,MOROSAWA T,et al.Branched chain amino acids are associated with the heterogeneity of the area of lipid droplets in hepatocytes of patients with non-alcoholic fatty liver disease[J].Hepatology Research,2019,49(8):860.
39. [39]
  TOMIYA T,OMATA M,FUJIWARA K.Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor[J].Biochemical and Biophysical Research Communications,2004,313(2):411.
40. [40]
  KAWAGUCHI T,IZUMI N,CHARLTON M,et al.Branched-chain amino acids as pharmacological nutrients in chronic liver disease[J].Hepatology,2011,54(3):1063.
41. [41]
  SORANOBU N,MASAHITO S,KENJI I,et al.Possible role of visfatin in hepatoma progression and the effects of branched-chain amino acids on visfatin-induced proliferation in human hepatoma cells[J].Cancer Prevention Research,2011,4(12):2092.
42. [42]
  LUO J.Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy[J].Cancer Letters,2009,273(2):194.
43. [43]
  DESBOIS-MOUTHON C,VAN EGGELPOË M J B,BEUREL E,et al.Dysregulation of glycogen synthase kinase-3β signaling in hepatocellular carcinoma cells[J].Hepatology,2002,36(6):1528.
44. [44]
  SUZUKI K,SUZUKI K,KOIZUMI K,et al.Measurement of serum branched-chain amino acids to tyrosine ratio level is useful in a prediction of a change of serum albumin level in chronic liver disease[J].Hepatology Research,2008,38(3):267.
45. [45]
  KAKAZU E,KANNO N,UENO Y,et al.Extracellular branched-chain amino acids,especially valine,regulate maturation and function of monocyte-derived dendritic cells[J].The Journal of Immunology,2007,179(10):7137.
46. [46]
  KAKAZU E,UENO Y,KONDO Y,et al.Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis[J].Hepatology,2009,50(6):1936.
47. [47]
  NAKAMURA I,OCHIAI K,MORIYASU F,et al.Restoration of innate host defense responses by oral supplementation of branched-chain amino acids in decompensated cirrhotic patients[J].Hepatology Research,2007,37(12):1062.
48. [48]
  HAGIWARA A,NISHIYAMA M,ISHIZAKI S.Branched-chain amino acids prevent insulin-induced hepatic tumor cell proliferation by inducing apoptosis through mTORC1 and mTORC2-dependent mechanisms[J].Journal of cellular physiology,2012,227(5):2097.
49. [49]
  KNERR I.Chapter 21-amino acid-related diseases[M]//DARDEVET D.The molecular nutrition of amino acids and proteins.Pittsburgh:Academic Press,2016:305-314.
50. [50]
  朱晓涵.苯丙酮尿症的致病机理与防治措施研究[J].化工中间体,2018(9):187.
51. [51]
  林明,张沙,肖军军,等.高苯丙氨酸血症控制期患者血清氨基酸测定结果与正常人群的比较[C]//中国优生科学协会.高苯丙氨酸血症筛查治疗与康复学术研讨会资料汇编.北京:[出版者不详],2008:20-25.
52. [52]
  张磊,徐晓恒,张思瑾.苯丙酮尿症的治疗研究进展[J].中国当代儿科杂志,2009,11(9):786.
53. [53]
  LICHTER-KONECKI U,VOCKLEY J.Phenylketonuria:current treatments and future developments[J].Drugs,2019,79(5):495.
54. [54]
  MACDONALD A,ROCHA J C,VAN RIJN M,et al.Nutrition in phenylketonuria[J].Molecular Genetics and Metabolism,2011,104:S10.
55. [55]
  SARA G L,ALEJANDRA L M L,ISABEL I G,et al.Conventional phenylketonuria treatment[J].Journal of Inborn Errors of Metabolism and Screening,2016,4:1417.
56. [56]
  NIU R Q,FENG W X.Research progress of phenylketonuria and its releveant treatment[J].Chinese Journal of New Drugs,2018,27(2):154.
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沈阳化工大学材料科学与工程学院沈阳 110142

高F值寡肽的功能特性研究进展

作者简介: 秦于思(1996-),女,山东省日照市人,齐鲁工业大学硕士研究生,主要研究方向为乳品科学.;

Research progress in functional characteristics of high Fisher ratio oligopeptides

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通讯作者: 陈斌, bchen63@163.com

高F值寡肽的功能特性研究进展

作者简介:秦于思(1996-),女,山东省日照市人,齐鲁工业大学硕士研究生,主要研究方向为乳品科学.

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Research progress in functional characteristics of high Fisher ratio oligopeptides

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高F值寡肽的功能特性研究进展

作者简介: 秦于思(1996-),女,山东省日照市人,齐鲁工业大学硕士研究生,主要研究方向为乳品科学.;

Research progress in functional characteristics of high Fisher ratio oligopeptides

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通讯作者: 陈斌, bchen63@163.com

高F值寡肽的功能特性研究进展

作者简介:秦于思(1996-),女,山东省日照市人,齐鲁工业大学硕士研究生,主要研究方向为乳品科学.

English Abstract

Research progress in functional characteristics of high Fisher ratio oligopeptides

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