荧光传感分析法在抗生素残留检测中的应用研究进展
Research progress on the fluorescent sensing detection methods for the detection of antibiotic residues
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摘要: 在简述动物源性食品抗生素残留危害及抗生素残留检测方法研究现状的基础上,着重对基于碳量子点(CDs)、半导体量子点(QDs)、多孔金属有机骨架材料(MOFs)、上转换纳米材料(UCNPs)等的荧光传感分析法在抗生素残留检测中的应用研究进行了综述,认为:与传统检测方法相比,荧光传感分析法具有分析速度快、灵敏度高、可视化等优势。然而,由于食品的多样性和食品基质的复杂性,通常需要采用复杂的样品前处理步骤纯化和富集目标物,今后应重点开发与荧光传感分析法相适应的前处理技术或基质净化方法、新型荧光纳米材料及适用于现场检测的便携式荧光检测设备,并结合适配体、抗体及分子印迹等技术提高检测的专一性,以期为荧光传感分析法在动物源性食品抗生素残留检测领域中的实际应用提供参考。Abstract: Based on the brief introduction of the dangers of antibiotic residues and the current status of antibiotic detection technology, the fluorescence sensing methods based on carbon quantum dots, semiconductor quantum dots, metal-organic framework materials and upconversion nanomaterials for antibiotic detection application were reviewed. It pointed out that compared with traditional detection methods, fluorescence sensor detection method had the advantages of speediness, high sensitivity and visualization. However, due to the food matrix effect, complex sample pretreatment steps were often required to purify and enrich the target substance. Therefore, appropriate pretreatment technologies or matrix purification methods, new novel fluorescent nanomaterials, portable sensing detection equipment suitable for on-site detection,and the specificity of detection by combining aptamer,antibody and molecular imprinting techniques were the technological trend. It was expected that this review was able to provide a reference and theoretical basis for the practical applications of fluorescence sensing technology in antibiotic detection in the future.
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Key words:
- antibiotic residue /
- fluorescence probe /
- rapid detection /
- food safety
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